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Autoimmune Channelopathies In Paediatrics Epilepsy
Funder
National Health and Medical Research Council
Funding Amount
$47,877.00
Summary
Epilepsy is one of the commonest neurological disorders. Some children with epilepsy have a known cause for their epilepsy; however in most cases the cause is unknown. One of the proposed causes is auto antibodies targeted against specific brain channels, resulting in seizures. This study will determine whether some patients with epilepsy have antibodies in the blood that lead to epilepsy. By defining an immune mediated epilepsy, we can treat and stop the epilepsy.
Neurological Manifestations Of Experimental Neuronal Voltage-gated Potassium Channel Autoimmunity.
Funder
National Health and Medical Research Council
Funding Amount
$65,148.00
Summary
Antibodies against neuronal voltage-gated potassium channels (VGKC) are seen in various neurological illnesses, most commonly epilepsy and memory loss. The role of VGKC antibodies in the development of brain disease will be studied by immunizing rabbits against VGKC and transferring these antibodies to mice.
This research investigates the factors regulating the transition of the lung from the fluid filled organ in fetal life to the air filled organ required at birth. Many preterm babies fail this transition and in order to survive, their lungs often require mechanical ventilation, which has been suggested to cause lung injury. Using synchrotron generated X-rays, we can determine how particular resuscitation techniques are able to reduce this injury and promote aeration at birth.