Improving Muscular Dystrophy By Targeting The ADAMTS5 Metalloproteinase
Funder
National Health and Medical Research Council
Funding Amount
$658,571.00
Summary
Muscular dystrophy is a devastating childhood disorder. There is no cure and no effective therapy to stop the disease progressing to early death. Our pilot data show that muscular dystrophy in a mouse model is dramatically improved when the Adamts5 gene is inactivated. ADAMTS5 is an enzyme that remodels the extracellular matrix around cells. This suggests that inhibiting ADAMTS5 may be a new way to treat muscular dystrophy. We will test this idea in mice with muscular dystrophy
Rehearsals in Colonialism: Tracking Transpacific Expressions of Indigenous and Settler Sovereignty, 1788-1900. In the 1800s a spate of Pacific monarchies declared pre-emptive independence amidst the upheavals of circling imperial interest. Kingdoms in Tonga, Hawai'i, and New Zealand lasted at least a century, but only years in Tahiti, Samoa and Fiji. Nevertheless they epitomised uncertain times when Indigenous and settler peoples alike focussed intensely on the sovereign status of subject people ....Rehearsals in Colonialism: Tracking Transpacific Expressions of Indigenous and Settler Sovereignty, 1788-1900. In the 1800s a spate of Pacific monarchies declared pre-emptive independence amidst the upheavals of circling imperial interest. Kingdoms in Tonga, Hawai'i, and New Zealand lasted at least a century, but only years in Tahiti, Samoa and Fiji. Nevertheless they epitomised uncertain times when Indigenous and settler peoples alike focussed intensely on the sovereign status of subject peoples in subject colonies. This project connects these moments of sovereignty for the first time in a unique opportunity to track the intellectual and social histories of contact in the transcolonial space of the Pacific and its settler colonial rim. Project outcomes will offer new insight into our colonial past and its legacies in the present.Read moreRead less
Australian Fiction 1989 to 2005, and its National and Global Infrastructures. This project is a systematic analysis of Australian fiction published between 1989 and 2005: after the Australian Bicentenary and into the new millenium. It will look in particular at the relationship between national literary culture and globalisation. It examines the cultural, social, educational, political and economic aspects of this literary field, and accounts for its production and distribution, as well as the w ....Australian Fiction 1989 to 2005, and its National and Global Infrastructures. This project is a systematic analysis of Australian fiction published between 1989 and 2005: after the Australian Bicentenary and into the new millenium. It will look in particular at the relationship between national literary culture and globalisation. It examines the cultural, social, educational, political and economic aspects of this literary field, and accounts for its production and distribution, as well as the ways in which it is evaluated and put to use. It will be the first study of its kind, an analysis of contemporary Australian literary production in the fullest sense.Read moreRead less
Before, during and after Lapita: 5000 years of cultural continuity and transformation at Caution Bay, southern Papua New Guinea. Australia's closest Indigenous neighbours in southern Papua New Guinea have long been thought to have been in contact with long-distance seafarers only in the last 2000 years. This project will document recent archaeological findings that are causing a radical rethink of ancestral connections between Australia and southern Papua New Guinea.
Neural Control Of Behavioural State And Cognition - Role Of Nucleus Incertus And Relaxin-3
Funder
National Health and Medical Research Council
Funding Amount
$600,771.00
Summary
Dementia and mental illness are significant social and economic burdens worldwide and knowledge of underlying causes and more effective therapies are required. Our research is using preclinical models to characterize a little studied neural network in the control of arousal states, rhythmic brain activity, and learning and memory. Our findings could advance the development of improved treatments for cognitive deficits in degenerative, age-related and psychiatric disorders.
Land and colonial cultures: tracing Indigenous and settler transformation in the Pacific, 1850-1900. This research asks how conversations about land between settlers and Indigenous peoples in Australia, New Zealand, Hawai'i and Fiji shaped radically new landscapes of ownership during the 19th century. Its outcomes will illuminate the shared history of this region, while enhancing our historical foundations for facing postcolonial tensions over land.
Faith into Words: the entanglement of religion, politics and poetry in the work of Vincent Buckley. This project will explore poetry of Vincent Buckley, which is grounded in a conception of a God incarnate in the world and its people that impacted directly on Australia's secular culture and politics, and continues to offer to both secular and religious readers a way towards an inclusive human community.
Evaluating the Australian Popular Fiction Archive: A Definitive Critical History and Bibliography of Early to Late Colonial Genre Writing. This project analyses and evaluates Australian popular or genre fiction from the early to the late colonial period: from around the 1840s to the beginning of World War Two. It will chart a comprehensive history of colonial Australian genre fiction for the first time, producing two critical monographs and an online bibliography and digital archive which will f ....Evaluating the Australian Popular Fiction Archive: A Definitive Critical History and Bibliography of Early to Late Colonial Genre Writing. This project analyses and evaluates Australian popular or genre fiction from the early to the late colonial period: from around the 1840s to the beginning of World War Two. It will chart a comprehensive history of colonial Australian genre fiction for the first time, producing two critical monographs and an online bibliography and digital archive which will function as major reading, research and teaching resources. Understanding colonial popular fiction as a field of writing that expressed colonial sensibilities and performed colonial predicaments, this project will also demonstrate the formative role it played in the task of settlement and nation building.Read moreRead less
Ascending Control Of Behavioural State And Cognition - Role Of Nucleus Incertus And Relaxin-3 Transmission
Funder
National Health and Medical Research Council
Funding Amount
$540,356.00
Summary
Mental illness and dementia are significant social and economic burdens worldwide and knowledge of their underlying causes and more effective therapies are required. Our research aims to use pre-clinical models to characterize a little studied neuronal network implicated in control of brain theta rhythm activity, which could lead to improved treatment of neuropsychiatric diseases such as anxiety and depression, and degenerative cognitive decline.
Spare parts: the cultural history of organ transplantation. Organ transplantation is of considerable contemporary concern to Australians. Despite decades of campaigns seeking organ donors, this country has one of the world's lowest donation rates. This study will explore how this situation arose and offer a new understanding of the factors that impinge upon people's perceptions of transplantation.