About one in eight known genetic disorders involve DNA alteration that activates a cellular quality control mechanism that disables the affected gene. This mechanism is more efficient in some individuals than others. It can influence disease outcomes and severity. We will engineer and apply tools and models to measure and manipulate this crucial cellular mechanism. This will allow us to predict disease severity as well as to intervene where a manipulation of this mechanism will be beneficial.
The Role Of UPF3B And Nonsense Mediated MRNA Decay Surveillance In The Pathology Of Intellectual Disability.
Funder
National Health and Medical Research Council
Funding Amount
$789,954.00
Summary
Proper functioning of the nonsense mediated mRNA decay (NMD or 'mRNA police') is crucial for any cell to ensure normal development and function. When NMD is compromised the outcome is learning and memory problems, autism or schizophrenia. Under this project we study malfunctioning NMD using stem and neuronal cells derived from patients' skin cells. Some of the affected genes might be considered for therapeutic interventions. NMD is relevant to 1000s of human disorders and as such it is of fundam ....Proper functioning of the nonsense mediated mRNA decay (NMD or 'mRNA police') is crucial for any cell to ensure normal development and function. When NMD is compromised the outcome is learning and memory problems, autism or schizophrenia. Under this project we study malfunctioning NMD using stem and neuronal cells derived from patients' skin cells. Some of the affected genes might be considered for therapeutic interventions. NMD is relevant to 1000s of human disorders and as such it is of fundamental importance.Read moreRead less
Reconstructing the human colonisation of the Pacific using modern and ancient chicken DNA. We will reconstruct one of the last great human migrations, from Island Southeast Asia across the Pacific to Hawaii and Easter Island, using DNA from the domestic chicken, which was carried on the voyage. Ancient and modern DNA, and archaeological data will be used to reveal the source, route, timing, and whether contact was made with South America
Mechanical Factors In Normal Human Colonic Motility
Funder
National Health and Medical Research Council
Funding Amount
$650,023.00
Summary
Abnormal human colonic contractions cause significant medical, societal and financial burdens. Diagnosis and treatment of motility disorders requires an understanding of normal colonic contractility against which to measure dysfunction. Through state-of-the-art recording and analytical techniques, developed by the applicants, this project will provide the first clear description of normal human colonic motor patterns and how they are generated.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0238930
Funder
Australian Research Council
Funding Amount
$350,000.00
Summary
Austlit: The Australian Literature Gateway - Enhancement Stage Two. The Austlit: The Australian Literature Gateway Enhancement Stage Two Project will deliver enhanced functionality for researchers using the integrated resource discovery service developed in 2000 and 2001. In 2002, the Gateway will add new bibliographic, biographical and full text sources to the service, and map rich literary relationships based on this data, supporting the development of new research questions on the place of th ....Austlit: The Australian Literature Gateway - Enhancement Stage Two. The Austlit: The Australian Literature Gateway Enhancement Stage Two Project will deliver enhanced functionality for researchers using the integrated resource discovery service developed in 2000 and 2001. In 2002, the Gateway will add new bibliographic, biographical and full text sources to the service, and map rich literary relationships based on this data, supporting the development of new research questions on the place of the national literature in Australian culture. The Gateway's technical infrastructure will be developed to offer a sophisticated browsing interface, customised services to support specific research, and broader interoperability with other services, including flexible education and portal services.Read moreRead less
Lost Generation: Women Writers and Postwar Modernity. This project will restore a 'lost generation' of Australian women writers to, and reconfigure the meanings of, literary culture in the post-World War 2 years. 1945-65 is a key period of Australian cultural development that is under-researched but over-laden with stereotypes, which still frame and restrict our understanding of it. A fuller and more complex picture of Australian modernity and modernism will be gained by placing women centrally ....Lost Generation: Women Writers and Postwar Modernity. This project will restore a 'lost generation' of Australian women writers to, and reconfigure the meanings of, literary culture in the post-World War 2 years. 1945-65 is a key period of Australian cultural development that is under-researched but over-laden with stereotypes, which still frame and restrict our understanding of it. A fuller and more complex picture of Australian modernity and modernism will be gained by placing women centrally in the picture, and by placing the Australian case within the international field. Such an enhanced understanding of the past is essential for us to have a more productive and harmonious future, and to play a significant role internationally.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE110100225
Funder
Australian Research Council
Funding Amount
$600,000.00
Summary
Multi-dimensional, high speed laser imaging facility for fluids and combustion. New high-speed laser diagnostics facilities will be established to enable Australian researchers to perform unique, real time measurements in combustion systems. Such novel capabilities will advance the science of combustion and facilitate the development of design tools for the optimisation of clean and efficient energy conversion devices.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0347049
Funder
Australian Research Council
Funding Amount
$403,000.00
Summary
Building Australian Literary Knowledge Infrastructure. The primary goal of AustLit: the Australian Literature Gateway is to facilitate and encourage research in, and teaching of, the nation's creative and critical literature. AustLit's innovative world class resource discovery service utilises best practice techniques in information management and knowledge sharing. In 2003, AustLit will develop new technical services and important new content to meet the defined needs of a wide range of educati ....Building Australian Literary Knowledge Infrastructure. The primary goal of AustLit: the Australian Literature Gateway is to facilitate and encourage research in, and teaching of, the nation's creative and critical literature. AustLit's innovative world class resource discovery service utilises best practice techniques in information management and knowledge sharing. In 2003, AustLit will develop new technical services and important new content to meet the defined needs of a wide range of education and information consumers in the area. AustLit provides the foundation for a subject specific digital library that will retain and expand its usefulness into the future.Read moreRead less
Molecular and genetic analysis of epigenetic components in a model plant. Australia is a major exporter of agricultural food crops thus producers must maintain their competitive advantage in order to compete on the world stage. Food crops unfortunately have large, complex genomes that are not sequenced and a generation time of months that makes research outcomes slow to achieve. This project proposes to utilise a model plant that has a small completely sequenced genome and a short generation tim ....Molecular and genetic analysis of epigenetic components in a model plant. Australia is a major exporter of agricultural food crops thus producers must maintain their competitive advantage in order to compete on the world stage. Food crops unfortunately have large, complex genomes that are not sequenced and a generation time of months that makes research outcomes slow to achieve. This project proposes to utilise a model plant that has a small completely sequenced genome and a short generation time making it ideal to study the fundamental biological process of RNA silencing. Discoveries and outcomes from this project may have the potential to benefit Australian crops, ecosystems and human health.Read moreRead less
How The Lateral Habenula Integrates Behavioral And Autonomic Functions: The VTA Dopamine Connection
Funder
National Health and Medical Research Council
Funding Amount
$819,904.00
Summary
When adverse events occur, the lateral habenula, an old brain nucleus, helps calculate the wisest corrective action by contributing to the “brake” that controls the brain’s dopamine reward system. Our research will show how the lateral habenula links corrective changes in behavior with coordinated changes in temperature. Understanding this link will greatly contribute to understanding the brain mechanisms that regulate our physiology during stressful situations and as part of mental illness.