Improving The Surgical Outcomes For Barretts-derived Oesophageal Adenocarcinoma Through Early Detection.
Funder
National Health and Medical Research Council
Funding Amount
$796,144.00
Summary
Some people with severe reflux develop Barrett's oesophagus, which puts them at high risk of developing cancer. Patients with Barrett's can be monitored by regular endoscopy to detect cancer early enough so that they can be treated successfully with surgery. The aim of this work is to identify patients who are at highest risk of cancer using molecular biomarkers. We will then determine the cost effectiveness of using biomarkers for surveillance of patients with Barrett's oesophagus.
The Receptor-associated Protein (RAP) As A Molecular Chaperone For The Amyloid Protein (Abeta) Of Alzheimers Disease
Funder
National Health and Medical Research Council
Funding Amount
$402,403.00
Summary
Our research will examine the role of a protein known as the receptor-associated protein (RAP) in Alzheimer's disease. We will determine whether the protein contributes to the progression of Alzheimer's disease and we will examine the possiblity that that RAP may be used as a drug to treat the disease. The project could potentially have direct benefit for patients by leading to an effective treatment for dementia associated with Alzheimer's disease.
Capacity Building In Childhood And Adolescent Obesity Prevention
Funder
National Health and Medical Research Council
Funding Amount
$2,080,191.00
Summary
As obesity prevalence in children and adolescents continues to climb, there is an urgent need to build Australia's ability to undertake solutions-orientated research across several fronts. This program covers the four areas of greatest need for building research capacity in obesity prevention.Whole-of-community intervention programs: These evaluate what works and what does not work in the real world of trying to get integrated action at the community level and how to get the maximum uptake by ch ....As obesity prevalence in children and adolescents continues to climb, there is an urgent need to build Australia's ability to undertake solutions-orientated research across several fronts. This program covers the four areas of greatest need for building research capacity in obesity prevention.Whole-of-community intervention programs: These evaluate what works and what does not work in the real world of trying to get integrated action at the community level and how to get the maximum uptake by children and adolescents, their families, schools and other community settings.Assessing the cost-effectiveness of interventions: This research combines existing and emerging evidence with new modeling techniques to estimate the costs, population impacts, and cost-effectiveness of a variety of interventions.Socio-cultural contexts for obesity prevention: This research seeks to understand the various attitudes, beliefs, perceptions and values relating to food, physical activity and body size perception so that social marketing messages and intervention programs are socially and culturally appropriate and resonate with the variety of communities involved.Analysing policy processes and interventions: Policy changes are important early and powerful drivers of creating environments where the health choices are the easy choices, and the evidence base for such changes in obesity prevention is urgently needed.The four Lead Applicants in the team are all highly experienced researchers across the range of disciplines involved and are already working on a number of combined projects which will provide the research platform for the seven Team Investigators to build their skills. The Team Investigators are at various stages in their research careers and are already contributing to a significant extent. This capacity building grant will substantially boost this critical area of research by developing a team of cross-disciplinary researchers of international standing.Read moreRead less
Evaluating The Effectiveness Of Future Tobacco Control Strategies
Funder
National Health and Medical Research Council
Funding Amount
$368,112.00
Summary
This research will evaluate promising new strategies to reduce the harm caused by tobacco, the leading preventable cause of premature death in Australia. This includes evaluation of general population-based strategies, such as public smoking bans, and interventions to help smokers quit smoking, such as new cessation aids and long-term maintenance on pharmaceutical nicotine or low-nitrosamine smokeless tobacco.