Predicting Environmental Effects on Structure and Reactivity. This project tackles one of the most important and fundamental problems in theoretical chemistry: solvent effects on chemical reactions. The new methods and computer programs generated will be freely available to the Australian (and international) scientific communitities and will further enhance Australia's strong reputation in Theoretical Chemistry.
The applications chosen will allow new technologies in biosensing and strategies in ....Predicting Environmental Effects on Structure and Reactivity. This project tackles one of the most important and fundamental problems in theoretical chemistry: solvent effects on chemical reactions. The new methods and computer programs generated will be freely available to the Australian (and international) scientific communitities and will further enhance Australia's strong reputation in Theoretical Chemistry.
The applications chosen will allow new technologies in biosensing and strategies in computational drug design to be investigated. This will benefit the Australian biotechnology and pharmaceutical industries and may substantially aid in understanding the mechanism and treatment of disease. Read moreRead less
Electric field induced surface attachment and detachment of proteins. Microarrays are revolutionising the diagnosis of disease by enabling large amounts of data on genetics and protein expression to be obtained from one sample. Biosensors for diseases and toxins rely on the same mechanism, namely attachment of biological macromolecules to a surface. We propose a new method for controlling the attachment by micromachining an electrode system to apply an electric field to chosen sites. Ultimately ....Electric field induced surface attachment and detachment of proteins. Microarrays are revolutionising the diagnosis of disease by enabling large amounts of data on genetics and protein expression to be obtained from one sample. Biosensors for diseases and toxins rely on the same mechanism, namely attachment of biological macromolecules to a surface. We propose a new method for controlling the attachment by micromachining an electrode system to apply an electric field to chosen sites. Ultimately microelectronic engineering methods will be used. This will give control over the attachment process with potential benefits of orienting attaching molecules, minimising non-specific attachment and enriching diagnostics by enabling interrogation of the force of attachment.Read moreRead less
Industrial Transformation Research Hubs - Grant ID: IH150100028
Funder
Australian Research Council
Funding Amount
$3,708,510.00
Summary
ARC Research Hub for Integrated Device for End-user Analysis at Low-levels. ARC Research Hub for Integrated Device for End-user Analysis at Low-levels. This hub aims to improve detection of biological materials by building a portable device for rapid, time-critical detection of low-abundance molecular and cellular analytes. It is expected that the resulting technologies would be used at medical points of care, ordinary workplaces and centres of activity to test for tiny levels of targeted molecu ....ARC Research Hub for Integrated Device for End-user Analysis at Low-levels. ARC Research Hub for Integrated Device for End-user Analysis at Low-levels. This hub aims to improve detection of biological materials by building a portable device for rapid, time-critical detection of low-abundance molecular and cellular analytes. It is expected that the resulting technologies would be used at medical points of care, ordinary workplaces and centres of activity to test for tiny levels of targeted molecules. The initial focus would be early diagnosis of disease and point-of-care drug testing for humans and animals, but the technology platform could be used to sample food and environmental toxins. The hub expects these disruptive technologies will make Australian biotechnology, diagnostics, veterinary, agribusiness and manufacturing firms globally competitive.Read moreRead less
Process Chemistry for Distributed Manufacture of Nitric Acid. This project will benefit Australia by enabling a new approach to the manufacture of explosives for the country's mining industry which will provide the entire explosives supply chain with greater safety and security. Development of this technology will enhance Orica's competitive position as the largest manufacturer of mining explosives in the world and will produce wealth for the country through the continued success of this ASX Top ....Process Chemistry for Distributed Manufacture of Nitric Acid. This project will benefit Australia by enabling a new approach to the manufacture of explosives for the country's mining industry which will provide the entire explosives supply chain with greater safety and security. Development of this technology will enhance Orica's competitive position as the largest manufacturer of mining explosives in the world and will produce wealth for the country through the continued success of this ASX Top 50 company and the export of the technology.Read moreRead less
Miniaturised biosensors with high selectivity . This project aims to develop a technological platform for the fabrication of miniaturised and flexible sensors that enable the quantitative detection of important bioactive compounds such as fatty acids and biogenic amines. By utilising multi-enzymatic reactions in solid phase and engineering task-specific inks, chemiresistive sensors will be printed seamlessly as a whole. The sensors will respond to complex target biomolecules via a series of enzy ....Miniaturised biosensors with high selectivity . This project aims to develop a technological platform for the fabrication of miniaturised and flexible sensors that enable the quantitative detection of important bioactive compounds such as fatty acids and biogenic amines. By utilising multi-enzymatic reactions in solid phase and engineering task-specific inks, chemiresistive sensors will be printed seamlessly as a whole. The sensors will respond to complex target biomolecules via a series of enzymatic reactions through which the analyte will convert to much simpler, reactive and hence measurable molecules. This project will enable to design miniaturised sensors for point-of-care detection of biomolecules that cannot be yet evaluated by the end users.Read moreRead less
Molecular approaches to solving current and emerging problems in the epidemiology and diagnosis of Marek's disease in Australia. Marek's disease (MD) is a ubiquitous viral disease of chickens that is currently controlled in meat chickens by blanket vaccination of all chickens. However, as has happened overseas, the efficacy of the HVT vaccine being used in Australia is breaking down resulting in subclinical and clinical losses due to MD. To assist industry deal with this situation we propose to ....Molecular approaches to solving current and emerging problems in the epidemiology and diagnosis of Marek's disease in Australia. Marek's disease (MD) is a ubiquitous viral disease of chickens that is currently controlled in meat chickens by blanket vaccination of all chickens. However, as has happened overseas, the efficacy of the HVT vaccine being used in Australia is breaking down resulting in subclinical and clinical losses due to MD. To assist industry deal with this situation we propose to develop novel molecular methods for the quantification of Marek's disease viruses (MDV) in the host and the environment, to use these methods to design effective early monitoring systems for MD in broilers that predict disease and performance outcomes, and to develop an epidemiological model that will predict the spread and severity of MD as failure of vaccinal protection progresses.Read moreRead less
New Electronic Archives for Australian Literature. Information capacity in Australian literary studies has been dramatically expanded by national investment in electronic archives, while trends in the discipline increasingly demand empirical support for claims about literary history and literary value. At the same time, research about Australian literature remains primarily theoretical, insufficiently informed by newly available data. This project aims to further enrich the new data sets, and to ....New Electronic Archives for Australian Literature. Information capacity in Australian literary studies has been dramatically expanded by national investment in electronic archives, while trends in the discipline increasingly demand empirical support for claims about literary history and literary value. At the same time, research about Australian literature remains primarily theoretical, insufficiently informed by newly available data. This project aims to further enrich the new data sets, and to use them in an innovative return to the classical issues in Australian literary criticism and history. It will provide demonstration applications of data in new electronic archives.Read moreRead less
Our Island Home: The shifting map of Australian literature. This project will provide the first full-length study of the ways Australia's unique status as an island continent has shaped its national literature. Understanding this relationship will re-define the borders of its literature in three ways: it will establish new connections within the national literature between the literature of the mainland and surrounding islands; it will identify why certain regions such as the continental interio ....Our Island Home: The shifting map of Australian literature. This project will provide the first full-length study of the ways Australia's unique status as an island continent has shaped its national literature. Understanding this relationship will re-define the borders of its literature in three ways: it will establish new connections within the national literature between the literature of the mainland and surrounding islands; it will identify why certain regions such as the continental interior and outlying islands capture the literary imagination at particular times; it will bring to light ways for Australian literature to position itself within the shifting geographies of globalised modernity. Read moreRead less