Local Sleep In The Awake Brain: An Underlying Cause Of Neurobehavioural Deficits In Sleep Apnea?
Funder
National Health and Medical Research Council
Funding Amount
$582,330.00
Summary
Obstructive sleep apnea (OSA) is a common sleep disorder which significantly impacts daytime functioning leading to excessive sleepiness, and problems with attention and thinking. Currently, the causes for cognitive impairment in OSA (including attentional lapses and performance deficits) are poorly understood. In the awake state, groups of neurons can briefly go “offline” as they do in sleep. These periods of “local sleep” may explain impaired task performance in OSA.
Reconstructing the human colonisation of the Pacific using modern and ancient chicken DNA. We will reconstruct one of the last great human migrations, from Island Southeast Asia across the Pacific to Hawaii and Easter Island, using DNA from the domestic chicken, which was carried on the voyage. Ancient and modern DNA, and archaeological data will be used to reveal the source, route, timing, and whether contact was made with South America
Transdermal Testosterone Therapy: A Potential Treatment For Selective Serotonin Reuptake Inhibitor (SSRI)-associated Sexual Dysfunction In Women
Funder
National Health and Medical Research Council
Funding Amount
$241,351.00
Summary
Female sexual dysfunction (FSD) is frequently reported with selective serotonin reuptake inhibitor (SSRI) therapy and venlafaxine, these being the most common antidepressants used by Australian women. We have shown that testosterone therapy significantly improves sexual function in women with FSD. However SSRI-users have been excluded from these past studies. The aim of this study is to assess the efficacy of transdermal testosterone therapy for treatment of sexual dysfunction associated with SS ....Female sexual dysfunction (FSD) is frequently reported with selective serotonin reuptake inhibitor (SSRI) therapy and venlafaxine, these being the most common antidepressants used by Australian women. We have shown that testosterone therapy significantly improves sexual function in women with FSD. However SSRI-users have been excluded from these past studies. The aim of this study is to assess the efficacy of transdermal testosterone therapy for treatment of sexual dysfunction associated with SSRI therapy.Read moreRead less
Cracking the code of snails to elucidate parasite disease transmission. In Australia, a disease caused by liver flukes causes major economic losses to livestock production. The role of Australian pond snails as intermediate hosts for this parasite is poorly understood. This project aims to explore the phylogeography, biology and genomics of these snails. It expects to create novel molecular resources for important snail species and verify their roles as key vectors of flatworm parasites. The cur ....Cracking the code of snails to elucidate parasite disease transmission. In Australia, a disease caused by liver flukes causes major economic losses to livestock production. The role of Australian pond snails as intermediate hosts for this parasite is poorly understood. This project aims to explore the phylogeography, biology and genomics of these snails. It expects to create novel molecular resources for important snail species and verify their roles as key vectors of flatworm parasites. The curation of genomic and transcriptomic data sets, and elucidation of snail–parasite interactions will underpin the development of environmental diagnostic tests and deliver a new generation of intervention strategies to reduce the burden of liver fluke disease through the control of their snail intermediate hosts.Read moreRead less
New Electronic Archives for Australian Literature. Information capacity in Australian literary studies has been dramatically expanded by national investment in electronic archives, while trends in the discipline increasingly demand empirical support for claims about literary history and literary value. At the same time, research about Australian literature remains primarily theoretical, insufficiently informed by newly available data. This project aims to further enrich the new data sets, and to ....New Electronic Archives for Australian Literature. Information capacity in Australian literary studies has been dramatically expanded by national investment in electronic archives, while trends in the discipline increasingly demand empirical support for claims about literary history and literary value. At the same time, research about Australian literature remains primarily theoretical, insufficiently informed by newly available data. This project aims to further enrich the new data sets, and to use them in an innovative return to the classical issues in Australian literary criticism and history. It will provide demonstration applications of data in new electronic archives.Read moreRead less
Our Island Home: The shifting map of Australian literature. This project will provide the first full-length study of the ways Australia's unique status as an island continent has shaped its national literature. Understanding this relationship will re-define the borders of its literature in three ways: it will establish new connections within the national literature between the literature of the mainland and surrounding islands; it will identify why certain regions such as the continental interio ....Our Island Home: The shifting map of Australian literature. This project will provide the first full-length study of the ways Australia's unique status as an island continent has shaped its national literature. Understanding this relationship will re-define the borders of its literature in three ways: it will establish new connections within the national literature between the literature of the mainland and surrounding islands; it will identify why certain regions such as the continental interior and outlying islands capture the literary imagination at particular times; it will bring to light ways for Australian literature to position itself within the shifting geographies of globalised modernity. Read moreRead less
Excavating MacGregor: re-connecting a colonial museum collection. Sensing the impacts of colonisation, the first Administrator of British New Guinea William MacGregor made a significant collection of objects specifically for its future citizens. This comprehensive legacy of 13 000 objects did not remain in the country but was dispersed to three Australian and six overseas museums. Our aim is to re-assemble and re-connect this material by 'excavating' its private and official components. This res ....Excavating MacGregor: re-connecting a colonial museum collection. Sensing the impacts of colonisation, the first Administrator of British New Guinea William MacGregor made a significant collection of objects specifically for its future citizens. This comprehensive legacy of 13 000 objects did not remain in the country but was dispersed to three Australian and six overseas museums. Our aim is to re-assemble and re-connect this material by 'excavating' its private and official components. This research aims to focus on the makers and traders to disentangle the social relationships embedded in the objects. Using material-centred, assemblage-based archaeological approaches, we aim to investigate how indigenous groups used objects to negotiate with the new colonial government.Read moreRead less
Mechanisms And Therapies In Cardiovascular Disease
Funder
National Health and Medical Research Council
Funding Amount
$8,360,700.00
Summary
Cardiovascular disease (CVD) claims 1 person every 10 min in Australia and causes 1 in 3 deaths worldwide. The molecular and cellular processes underlying atherosclerosis, vascular injury and thrombosis are highly complex and not well understood. A multifaceted approach is needed to effectively address these key challenges. This Program brings together world experts in these areas to interrogate gaps in our basic understanding of CVD, and to develop novel therapies for CVD patients by exploiting ....Cardiovascular disease (CVD) claims 1 person every 10 min in Australia and causes 1 in 3 deaths worldwide. The molecular and cellular processes underlying atherosclerosis, vascular injury and thrombosis are highly complex and not well understood. A multifaceted approach is needed to effectively address these key challenges. This Program brings together world experts in these areas to interrogate gaps in our basic understanding of CVD, and to develop novel therapies for CVD patients by exploiting new knowledge through integrated research.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE140100254
Funder
Australian Research Council
Funding Amount
$395,205.00
Summary
The oldest rock art in Asia and the early human occupation of island Southeast Asia. Recent research revealed that humans were producing rock paintings on the Indonesian island of Sulawesi at least 39 thousand years ago (and possibly up to 46 thousand years ago). The rock art, therefore, is essentially contemporaneous with the earliest cave art in Europe and may be the world's oldest, given the arrival of Homo sapiens in Australia at least 50 thousand years ago. This project will further investi ....The oldest rock art in Asia and the early human occupation of island Southeast Asia. Recent research revealed that humans were producing rock paintings on the Indonesian island of Sulawesi at least 39 thousand years ago (and possibly up to 46 thousand years ago). The rock art, therefore, is essentially contemporaneous with the earliest cave art in Europe and may be the world's oldest, given the arrival of Homo sapiens in Australia at least 50 thousand years ago. This project will further investigate the early rock art of Sulawesi as well as other key Indonesian islands located along likely migration routes from Borneo to New Guinea. The results will have major implications for our understanding of the cultural behaviour and dispersal of the earliest modern humans to colonise Southeast Asia and Australia.Read moreRead less
Archaeologies of community and colonialism in Oceania. This project aims to understand the colonial past, its repercussions for the present and future in Oceania and the relationships between global forces and local experiences. It will use an interdisciplinary approach to historical archaeology and community archaeology. The unique colonial landscapes in Mangareva, French Polynesia will provide a landmark case study with global implications. In addition to internationally significant scholarly ....Archaeologies of community and colonialism in Oceania. This project aims to understand the colonial past, its repercussions for the present and future in Oceania and the relationships between global forces and local experiences. It will use an interdisciplinary approach to historical archaeology and community archaeology. The unique colonial landscapes in Mangareva, French Polynesia will provide a landmark case study with global implications. In addition to internationally significant scholarly outputs and collaboration development, the project will make a substantive contribution to public outreach and education. Benefits would include advancement of Oceanic contributions to global historical archaeology, and increased awareness of the meanings of colonial heritage among Pacific peoples.Read moreRead less