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Harnessing The Dual Roles Of Pericytes To Improve Stroke Outcomes
Funder
National Health and Medical Research Council
Funding Amount
$853,943.00
Summary
Pericytes are cells that are in the walls of capillaries - the smallest blood vessels. Pericytes control blood flow and help promote recovery after injury. In stroke, pericytes squeeze the capillary shut, limiting the amount of energy getting to the brain. This proposal will use innovative techniques to understand how pericytes limit blood flow and also how we can utilise pericytes to improve brain recovery after stroke. This will allow us to identify new potential treatment options for stroke.
Discovering How A Novel Anti-malarial Drug Series Rapidly Kills Parasites
Funder
National Health and Medical Research Council
Funding Amount
$672,971.00
Summary
We have developed a new set of highly potent anti-malarial drugs but we do not know how they work. Identifying how these compounds work is important for improving their effectiveness and safety. We will discover how these drugs kill parasites by using a number of cutting edge methods that could also be useful for discovering how other drugs work. Data generated will progress these compounds along the drug development pipeline which urgently needs a constant supply of new antimalarials.