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Investigating The Involvement Of Human Derived Astrocytes And Motor Neurons In The Pathology Of Motor Neuron Disease.
Funder
National Health and Medical Research Council
Funding Amount
$287,321.00
Summary
Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease, which results in the death of nerves that innervate muscle, known as motor neurons. Recent studies using mouse ALS models showed that certain cells that normally support motor neurons may be directly contributing to their death in ALS. We propose to derive ALS-diseased human cells and investigate how these cells may react in ‘normal’ tissue. These studies are clinically relevant in understanding ALS pathological processes.
Using Astrocytes To Protect The Brain From Injury: Investigating Mechanisms And Therapeutic Strategies.
Funder
National Health and Medical Research Council
Funding Amount
$374,310.00
Summary
Brain damage caused by hypoxia (lack of oxygen) is a common problem in babies and can lead to outcomes ranging from cerebral palsy to death. We have a limited understanding of the mechanisms that cause damage, and thus very limited treatments. This project will investigate the role of cells called astrocytes in brain injury and identify novel therapeutic strategies to prevent or reverse brain damage. The outcomes of this research will ultimately lead to new treatments for hypoxic brain injury.
Analysis Of T Cell Fate Regulation By Asymmetric Cell Division
Funder
National Health and Medical Research Council
Funding Amount
$287,321.00
Summary
The aim of this research is to study how white blood cell growth is regulated by signals of the immune system. Problems in this process can have drastic effects on the well being of an individual leading to deficiencies in controlling infection and development of diseases such as cancer. Once we understand how these signals regulate white blood cell growth, we can begin to develop therapies to provide protection against these diseases.
Unravelling The Molecular Basis Of Amyotrophic Lateral Sclerosis
Funder
National Health and Medical Research Council
Funding Amount
$342,325.00
Summary
The only known causes of ALS are gene mutations. State-of-the-art technologies will be used to find genetic causes of ALS to add to existing diagnostic testing and facilitate investigation into disease mechanism. ALS patients experience different disease courses, with variable age of onset, progression and duration of disease even among those with identical gene mutations. We will examine a well-characterised ALS patient cohort with differing disease manifestations to identify disease modifiers.
SPARC Induced Tendon Differentiation And Regeneration
Funder
National Health and Medical Research Council
Funding Amount
$154,718.00
Summary
Tendinopathy has a significant patient morbidity, which is a clear burden to the Australian economy. A better fundamental grasp of tendon tissue biology is urgently required. This study will enable us to establish the role of matricellular protein SPARC in tendon function, thus enhance the understanding of tendon biology and enable translation of the bench work to potential clinical applications.