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Brain sodium channel: functional role of developmentally regulated alternative splicing. This project will identify the roles of neonatal and adult forms of a sodium channel in the function of neurons in the developing brain. Sodium channels are vital for brain function and this study will improve our understanding of the function of healthy brain as well as of underlying mechanisms of some neurological disorders.
Enhanced brain and muscle signal separation verified by electrical scalp recordings from paralysed awake humans. This project will develop algorithms to separate brain signals from muscle signals in electrical recordings from the scalp. Cleaner brain signal measurement enables improvements in understanding how the brain works, the diagnosis and management of neurological diseases, and the development of brain-controlled devices for very disabled people.
Empathy, Attention and Reasoning: The role of automatic and controlled processing in emotion recognition following traumatic brain injury. Traumatically brain injured adults have difficulty identifying emotional facial expressions but little is known regarding their psychophysiological reactions to emotional expression, the efficacy of their visual search patterns of facial features or the extent to which they engage conscious processing and problem solving to assist interpretation. Nor is anyth ....Empathy, Attention and Reasoning: The role of automatic and controlled processing in emotion recognition following traumatic brain injury. Traumatically brain injured adults have difficulty identifying emotional facial expressions but little is known regarding their psychophysiological reactions to emotional expression, the efficacy of their visual search patterns of facial features or the extent to which they engage conscious processing and problem solving to assist interpretation. Nor is anything known about their ability to recognise dynamic emotional displays compared to photographs. This project examines each of these facets using static and dynamic portrayals. The project will inform neuropsychological theories of facial processing, test the ecological validity of previous research and improve understanding of psychosocial deficits after TBI and their treatment.Read moreRead less
Hemispheric asymmetry of motor and language representation: Effects of hand preference and mirror movements. The neuroscience community has recently exploited advances in brain imaging to understand cerebral representation of many cognitive functions. The proposed study will expand our knowledge of brain-behaviour relationships, another key area of cognitive neuroscience research. Its successful funding and completion will increase Australia's standing as a major contributor to world research ou ....Hemispheric asymmetry of motor and language representation: Effects of hand preference and mirror movements. The neuroscience community has recently exploited advances in brain imaging to understand cerebral representation of many cognitive functions. The proposed study will expand our knowledge of brain-behaviour relationships, another key area of cognitive neuroscience research. Its successful funding and completion will increase Australia's standing as a major contributor to world research outcomes in this innovative and important field, and place Australia at its forefront. The investigator's access to advanced brain imaging and to the unique population of individuals with mirror movements, combined with expertise and experience in neuropsychology and brain imaging, places the research in an internationally competitive position.Read moreRead less
The molecular role of ADAM12 in maintenance of skeletal muscle, myogenesis and adipogenesis. An understanding of the molecular control of skeletal muscle growth, maintenance and balance between muscle and fat production is of fundamental importance for a competitive meat industry, for the promotion of strong muscles in the ageing population and for disorders such as muscle diseases, diabetes and obesity. This project will enhance strong international collaborations and expand cutting-edge resear ....The molecular role of ADAM12 in maintenance of skeletal muscle, myogenesis and adipogenesis. An understanding of the molecular control of skeletal muscle growth, maintenance and balance between muscle and fat production is of fundamental importance for a competitive meat industry, for the promotion of strong muscles in the ageing population and for disorders such as muscle diseases, diabetes and obesity. This project will enhance strong international collaborations and expand cutting-edge research within Australia with many potential economic benefits for the meat industry, biotechnology and health. The expertise developed by this pioneering research will ensure that Australia is well placed to harness new technologies and exploit future advances in this fast-moving field of muscle biology.Read moreRead less
The capacity for exceptional brain repair in a novel rodent species. This project aims to provide a new and much-needed living tool for studying brain injury and repair. The project expects to generate new evidence of effective brain repair in a mammalian species, the spiny mouse. In particular, it will provide important knowledge of the cellular responses that coordinate to allow mammalian brain repair, revealing targets for future understanding and treatment. Expected outcomes include an in-de ....The capacity for exceptional brain repair in a novel rodent species. This project aims to provide a new and much-needed living tool for studying brain injury and repair. The project expects to generate new evidence of effective brain repair in a mammalian species, the spiny mouse. In particular, it will provide important knowledge of the cellular responses that coordinate to allow mammalian brain repair, revealing targets for future understanding and treatment. Expected outcomes include an in-depth characterisation of how neurons and non-neuronal cells (glia) contribute to brain repair, and the identification of new pathways or targets for mammalian brain repair. In the long-term this should provide significant benefits for future research focused on improving the lives of people affected by brain injury. Read moreRead less
Deciphering the cellular defences against aggregating proteins in human disease. Cells have inbuilt defences for coping with proteins that bend into abnormal sticky shapes that form toxic clusters. In many diseases, including Huntington's, the clusters severely damage nerve cells. This project will identify the genes and mechanisms cells use to protect themselves from toxic clusters, which could provide new therapeutic targets.
Molecular dissection of the functional regions of genes that encode actinins (ACTN2 and ACTN3) and their contribution to normal variation in skeletal muscle function. The project has discovered a common genetic variant that affects skeletal muscle structure, function and metabolism and influences athletic ability, and response to diet and exercise. The project will study how this gene influences muscle bulk and strength, the metabolic efficiency of muscle and the risk of obesity in the general ....Molecular dissection of the functional regions of genes that encode actinins (ACTN2 and ACTN3) and their contribution to normal variation in skeletal muscle function. The project has discovered a common genetic variant that affects skeletal muscle structure, function and metabolism and influences athletic ability, and response to diet and exercise. The project will study how this gene influences muscle bulk and strength, the metabolic efficiency of muscle and the risk of obesity in the general population.Read moreRead less
Control of language production and its neural substrates. The ability of humans to say the right word at the right time is a critical, complex and poorly understood function. This research will determine the brain circuits responsible for language production and how this process is affected in Parkinson's disease.
The burden of epilepsy study: Impact on well-being, service use and economic outcomes. This research into the humanitarian needs of people with epilepsy is a necessary extension to the current bulk of knowledge about epilepsy which is diagnostic, clinical and pharmacological. Its focus is on well-being, service use and economic burden this study is expected to give a good return on investment. To ensure an uptake of its findings, the study was developed with the national Epilepsy Action, Epilep ....The burden of epilepsy study: Impact on well-being, service use and economic outcomes. This research into the humanitarian needs of people with epilepsy is a necessary extension to the current bulk of knowledge about epilepsy which is diagnostic, clinical and pharmacological. Its focus is on well-being, service use and economic burden this study is expected to give a good return on investment. To ensure an uptake of its findings, the study was developed with the national Epilepsy Action, Epilepsy Society of Australia as well as addressing questions deemed important by the World Health Organization, the International League against Epilepsy, and the International Bureau of Epilepsy. Findings will inform epilepsy guidelines, policy recommendations and programs to reduce the burden of illness.Read moreRead less