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Understanding The Mechanisms Of PTEN Transfer Into Glial Cells Using Exosomes
Funder
National Health and Medical Research Council
Funding Amount
$567,253.00
Summary
This application will develop a new way of treating brain cancer which currently affects 1500 adults in Australia per year with no lasting cures. The average patient with a malignant brain tumour do not survive for more than 12 months. We have discovered a method of restoring a cancer suppressor substance that is lost from brain tumours. If successful, this treatment has the potential to limit or reverse the progression of brain tumours.
SEZ6 AND NEURONAL CALCIUM SIGNALLING IN SYNAPSE DEVELOPMENT
Funder
National Health and Medical Research Council
Funding Amount
$617,685.00
Summary
Inappropriate development and function of neuronal circuits is a universal feature of neurological disorders of cognition such as Down syndrome, autism spectrum disorders and Fragile X mental retardation, epilepsy, schizophrenia and Alzheimer�s disease. In these diseases, neurons exhibit abnormal neuronal branches (dendrites) and abnormal connections on dendritic spines. This research is aimed at understanding the mechanisms controlling dendrite development that underpin proper neuronal wiring.
Neogenin: A Regulator Of Neuronal Differentiation And Migration In The Adult Brain
Funder
National Health and Medical Research Council
Funding Amount
$334,053.00
Summary
Conditions such as Alzheimer�s and Huntington�s diseases, as well as stroke, represent a major burden of disease in Australia. One goal of modern neurobiology is to harness the brain's ability to make new neurons so that we can replace those damaged by disease or injury. We will investigate how an important developmental molecule, Neogenin, promotes the production of new neurons in the adult brain. A second goal is to show that Neogenin can be activated to promote the repair of the damaged brain ....Conditions such as Alzheimer�s and Huntington�s diseases, as well as stroke, represent a major burden of disease in Australia. One goal of modern neurobiology is to harness the brain's ability to make new neurons so that we can replace those damaged by disease or injury. We will investigate how an important developmental molecule, Neogenin, promotes the production of new neurons in the adult brain. A second goal is to show that Neogenin can be activated to promote the repair of the damaged brain.Read moreRead less
The PDZ Scaffold NHERF-1; A Novel Regulator Of Astrocyte Function?
Funder
National Health and Medical Research Council
Funding Amount
$444,500.00
Summary
Astrocytes are a vital cell type in the human brain. They provide nutrients to neurons, remove toxic chemicals such as glutamate (a neurotransmitter), as well as stabilising the levels of molecules such as water and ions such as sodium, bicarbonate and potassium. Astrocytes perform all these tasks by means of specialised protein molecules called transporters that are embedded in their cell membranes. These transporters are not uniformly distributed; they are positioned in those parts of the astr ....Astrocytes are a vital cell type in the human brain. They provide nutrients to neurons, remove toxic chemicals such as glutamate (a neurotransmitter), as well as stabilising the levels of molecules such as water and ions such as sodium, bicarbonate and potassium. Astrocytes perform all these tasks by means of specialised protein molecules called transporters that are embedded in their cell membranes. These transporters are not uniformly distributed; they are positioned in those parts of the astrocyte membranes where the particular biological job has to be performed. How are they targeted to, and retained in these places? We have preliminary data suggesting that a specialised protein called NHERF-1, can bind a group of these proteins, called glutamate transporters, thereby anchoring them to the skeleton of the cell. If we are correct then we should be able to manipulate this interaction, both in live brain tissues, and in simple cell culture systems, using a variety of physiological and molecular biology techniques. If we are correct in our hypothesis, then our findings will have immense value in trying to reduce damage that occurs in human brains in conditions such as strokes, where a breakdown in the control of glutamate around neurons causes extensive and irreversible brain damage.Read moreRead less