Drivers of ageing and adaptive ageing in middle-aged and older adults. This project aims to answer crucial questions about how our early years influence our health and wellbeing in middle and later life. Drawing on one of Australia’s longest running studies of social and emotional development, we link decades of developmental data collected since 1983 to social, emotional, cognitive and physical wellbeing in participants turning 40 (midlife) and 70 (later life). It will provide insight into impo ....Drivers of ageing and adaptive ageing in middle-aged and older adults. This project aims to answer crucial questions about how our early years influence our health and wellbeing in middle and later life. Drawing on one of Australia’s longest running studies of social and emotional development, we link decades of developmental data collected since 1983 to social, emotional, cognitive and physical wellbeing in participants turning 40 (midlife) and 70 (later life). It will provide insight into important and largely unanswered questions about the way social factors in the first half of life shape our later selves. This study will inform government and health policy targeting ageing populations.
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Glucose facilitation of cognitive function: Effects of effort, age and glucose control. Age-related decline in mental capacity contributes to the economic (estimated at over 2 trillion AUD by 2050), social and human costs of an increasingly older Australian population. The studies in this program aim to understand the role of poor control of blood glucose in age-related cognitive deficits. The role of individual differences in biological (hormonal responses) and psychological (stress and appetit ....Glucose facilitation of cognitive function: Effects of effort, age and glucose control. Age-related decline in mental capacity contributes to the economic (estimated at over 2 trillion AUD by 2050), social and human costs of an increasingly older Australian population. The studies in this program aim to understand the role of poor control of blood glucose in age-related cognitive deficits. The role of individual differences in biological (hormonal responses) and psychological (stress and appetite) factors will also be assessed. A better understanding of the nature of age-related cognitive decline as it relates to biological processes such as blood glucose control will help to develop tangible strategies to combat age-related cognitive decline and dementia (which has been described as Type 3 diabetes).Read moreRead less
Revisiting the 'Fourth Age': health, socioeconomic and cultural transformation of, and diversity in, Australia's oldest old population, 1981-2011. The oldest-old (those aged 85 years and over) is the fastest growing segment of the Australian population, and the changing make-up and experiences of this group needs attention. This project will expand our knowledge base about Australia's oldest old, helping to inform public policy and to improve discussions on what the 'Fourth Age' really means in ....Revisiting the 'Fourth Age': health, socioeconomic and cultural transformation of, and diversity in, Australia's oldest old population, 1981-2011. The oldest-old (those aged 85 years and over) is the fastest growing segment of the Australian population, and the changing make-up and experiences of this group needs attention. This project will expand our knowledge base about Australia's oldest old, helping to inform public policy and to improve discussions on what the 'Fourth Age' really means in Australia.Read moreRead less
Meeting the needs of older persons in Indonesia. The project aims to identify the needs of older people in rural Indonesia for income, housing, health, daily care and social interaction and the extent to which their needs are met. It also considers the efficacy of existing policy programs and how these might be improved. Today, there are 22 million Indonesians aged 60 years and over, projected to rise to 48 million by 2035. Millions of older people live in rural areas from which younger people h ....Meeting the needs of older persons in Indonesia. The project aims to identify the needs of older people in rural Indonesia for income, housing, health, daily care and social interaction and the extent to which their needs are met. It also considers the efficacy of existing policy programs and how these might be improved. Today, there are 22 million Indonesians aged 60 years and over, projected to rise to 48 million by 2035. Millions of older people live in rural areas from which younger people have moved to the rapidly growing cities. This presents challenges for the traditional family-based aged care system in Indonesia. It is expected that findings from the study will be published in a series of policy papers to be presented in the Indonesian National Development Planning Board.Read moreRead less
Improving neuronal cell function with cell permeable copper complexes. Metal-based drugs offer an exciting new approach to treatment of neurodegeneration. However, little is known about how cells metabolise these drugs and this information is critical for further drug development. This project will determine how metal-based drugs are metabolised by neuronal cells and how this may result in therapeutic benefit.
Ageing and the allocation of selective attention over time: behavioural, neurophysiological and neuroanatomical correlates. Only by fully understanding cognitive decline that occurs with age can we hope to provide appropriate interventions to slow or arrest the underlying neural degeneration. Part A, the first of three consecutive parts, will use novel paradigms to investigate various aspects of selective attention and cognition. Part B will investigate the regions of the brain underlying the te ....Ageing and the allocation of selective attention over time: behavioural, neurophysiological and neuroanatomical correlates. Only by fully understanding cognitive decline that occurs with age can we hope to provide appropriate interventions to slow or arrest the underlying neural degeneration. Part A, the first of three consecutive parts, will use novel paradigms to investigate various aspects of selective attention and cognition. Part B will investigate the regions of the brain underlying the temporal allocation of selective attention by comparing the performance of patients with focal lesions, and separately by using event-related potential (ERP) technology. Finally, Part C will evaluate the rate and type of cognitive decline with age using a range of reaction time-independent tasksRead moreRead less
Continuity and change in the development of young children with autism. Autism is a severe condition affecting social interaction, communication, behaviour and interests. Parents of children with autism experience high levels of stress associated with the burden of caring. There is a high societal cost associated with the care of people with autism. Research shows outcome in autism is poor, but that early intervention may improve outcome. This project will identify specific early precursors of a ....Continuity and change in the development of young children with autism. Autism is a severe condition affecting social interaction, communication, behaviour and interests. Parents of children with autism experience high levels of stress associated with the burden of caring. There is a high societal cost associated with the care of people with autism. Research shows outcome in autism is poor, but that early intervention may improve outcome. This project will identify specific early precursors of autism which predict outcome. This will allow the development of targeted intervention to give children the best possible start in life and improve longterm outcome. Improvement to the outcome of people with autism will considerably reduce parental and family burden and cost to the community.Read moreRead less
Attentional mechanisms in the relationship between sleep disruption and academic outcomes in Australian school children. This project will assess the impact of sleep problems on attention and academic performance in primary school children. The project will investigate typically developing children and children with developmental disorders over 18 months. The research will advance knowledge of the interplay between sleep, attention and learning across development.
Social outcomes, behaviour and emotional well-being of adults with autism. It is recognised that autism results in substantial life-long disability. Severe emotional and behavioural problems are likely to be a key factor in precluding adults with autism from work, independent living, social contact, and undermine their quality of life, thus increasing support needs. This project aims to address a major gap in our current knowledge - the association between severe emotional and behavioural proble ....Social outcomes, behaviour and emotional well-being of adults with autism. It is recognised that autism results in substantial life-long disability. Severe emotional and behavioural problems are likely to be a key factor in precluding adults with autism from work, independent living, social contact, and undermine their quality of life, thus increasing support needs. This project aims to address a major gap in our current knowledge - the association between severe emotional and behavioural problems in adults with autism and social outcomes. Identification of markers of adult outcomes aims to lead to an improved understanding of the pathways to better social outcomes, facilitating the development of specific interventions to provide much needed improvements in outcomes for adults with autism.Read moreRead less
Improving cognitive function in the elderly. The ageing population has been identified as one of the major issues facing contemporary Australian society. For Australia, human ageing has significant societal, economic and, importantly, personal/human costs. The economic costs associated with ageing reflect decreased productivity as well as a higher incidence of a variety of illnesses including cardiovascular and respiratory disease and, importantly, neurological conditions such as Parkinson's dis ....Improving cognitive function in the elderly. The ageing population has been identified as one of the major issues facing contemporary Australian society. For Australia, human ageing has significant societal, economic and, importantly, personal/human costs. The economic costs associated with ageing reflect decreased productivity as well as a higher incidence of a variety of illnesses including cardiovascular and respiratory disease and, importantly, neurological conditions such as Parkinson's disease (PD) and Alzheimer's disease (AD). We will complete two large scale studies examining the efficacy of twelve months administration of two pharmacologically active supplements in reducing the cognitive effects of aging in elderly participants.
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