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Nerve cell survival is dependent on both growth-promoting factors and factors released by neurotransmission, which can promote recovery in neurodegenerative conditions by overriding cell death pathways. The molecule responsible for activating death pathways in the nervous system is called p75. This project will investigate how p75 results in cell death, how synaptic signals can prevent the activation of the p75 death pathway and whether blocking p75 function can limit neurodegeneration.
Improving Bionic Device Safety And Performance With Conductive Hydrogels
Funder
National Health and Medical Research Council
Funding Amount
$425,048.00
Summary
Bionic devices are being developed to treat a variety of neural disorders including blindness. Conductive hydrogels (CHs) are a new soft material developed by the CI to improve device performance and safety. This project will explore CH technologies with an aim of producing flexible organic electronics for high resolution devices, such as the bionic eye. Collaboration will be sought through industry, academia and clinical researchers to accelerate technology translation from bench to bedside.
Investigation Of The Molecular Mechanisms Underlying Alpha Synuclein Function At The Presynapse
Funder
National Health and Medical Research Council
Funding Amount
$419,180.00
Summary
Parkinson’s Disease (PD) is a common brain disease affecting 7 million people worldwide. It is caused by the death of brain cells. ?-synuclein is a protein in that brain that is likely to contribute to the cell death in PD, but the normal role of the protein remains unknown. This study will investigate the function of ?-synuclein in maintaining normal healthy brain activity. In addition, this work will help us understand how normal brain processes are affected in diseases such as PD.
Is Stroke Neurodegenerative? A Longitudinal Study Of Changes In Brain Volume And Cognition Following Stroke
Funder
National Health and Medical Research Council
Funding Amount
$290,946.00
Summary
There is no direct evidence linking Alzheimer’s Disease (AD) and stroke. It is unknown whether stroke can trigger progressive dementia in the same way as AD. In a group of stroke patients, I will measure MRI brain volume and cognition in the 5 years after stroke. These findings will be critical for identification of those patients most at risk of dementia after stroke. This may allow future early intervention for these patients, via promising AD disease-modifying therapies.
Neurodegenerative Disease Pathology, Mechanisms, Models And Treatments
Funder
National Health and Medical Research Council
Funding Amount
$431,000.00
Summary
Frontotemporal dementia (FTD) and motor neuron disease (MND) are fatal and incurable neurodegenerative diseases. Although dissimilar in symptoms, most cases of both FTD and MND are characterised at autopsy by abnormal accumulations of the TDP-43 protein in neurons. In this fellowship, I will characterise the biochemical changes caused by TDP-43 malfunction that occur in both FTD and MND and test potential new therapeutics in mice, to identify new ways to treat these devastating diseases.
Modifiable Risks And Interventions For Cognitive Decline, Depression And Dementia In Older People
Funder
National Health and Medical Research Council
Funding Amount
$430,055.00
Summary
This research proposal will explore the modifiable risk factors for cognitive decline (ie. changes in memory and thinking functions) in older people. It will examine the pertinence of critical contributors to glial-neuronal networks including depression, cardiovascular disease, sleep-wake systems, mental and physical exercise, inflammatory processes and diet, as well as test interventions that target these risk factors. It will use sophisticated brain scanning methods to examine which factors pr ....This research proposal will explore the modifiable risk factors for cognitive decline (ie. changes in memory and thinking functions) in older people. It will examine the pertinence of critical contributors to glial-neuronal networks including depression, cardiovascular disease, sleep-wake systems, mental and physical exercise, inflammatory processes and diet, as well as test interventions that target these risk factors. It will use sophisticated brain scanning methods to examine which factors promote neuroplasticity.Read moreRead less