Moving Behavioural Neuroscience & Neuroeconomics Into Dementia Prevention: Spatial Tracking And Economic Decision-making As New Sensitive Measures Of Daily Function
Funder
National Health and Medical Research Council
Funding Amount
$595,588.00
Summary
This project will aim to develop new measures for clinical trials by learning the relationship between older people's movements around the house, ability to make decisions about their health and finance and their cognitive performance. These instruments may aid future trials of drugs and other interventions for preventing dementia by indicating how basic behavioural patterns respond to interventions.
Epistatic Genetic Effects On Neuroanatomical Subtypes Of Schizophrenia
Funder
National Health and Medical Research Council
Funding Amount
$410,141.00
Summary
Schizophrenia represents a number of clinically distinct syndromes, with a complex mode of inheritance. The delineation of biologically valid subtypes of schizophrenia is necessary to advance our understanding of the genetic basis of these syndromes. This project uses pattern classification techniques to determine subtypes of schizophrenia on the basis of structural brain abnormality across multiple regions, and will examine genetic interactions and differential gene expression associated with t ....Schizophrenia represents a number of clinically distinct syndromes, with a complex mode of inheritance. The delineation of biologically valid subtypes of schizophrenia is necessary to advance our understanding of the genetic basis of these syndromes. This project uses pattern classification techniques to determine subtypes of schizophrenia on the basis of structural brain abnormality across multiple regions, and will examine genetic interactions and differential gene expression associated with these biologically-derived subtypes.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE170100915
Funder
Australian Research Council
Funding Amount
$345,000.00
Summary
Uncovering the dynamics of object selection from movement trajectories. This project aims to establish the dynamic properties of selection for perception and action, and develop a computational model of object selection across perception and action. Everyday actions depend on isolating the relevant object (perceptual selection) and appropriate grasp (action selection). It was long thought that distinct and sequential stages of processing carried out perceptual and action selection, but recent fi ....Uncovering the dynamics of object selection from movement trajectories. This project aims to establish the dynamic properties of selection for perception and action, and develop a computational model of object selection across perception and action. Everyday actions depend on isolating the relevant object (perceptual selection) and appropriate grasp (action selection). It was long thought that distinct and sequential stages of processing carried out perceptual and action selection, but recent findings suggested that a single mechanism may subserve both. Through a two-pronged approach including rigorous empirical work and computational modelling, this project aims to study this fundamental aspect of human cognition.Read moreRead less
Identifying Malingered Posttraumatic Stress Disorder: Biological Markers for Legal Assessment. Posttraumatic stress disorder (PTSD) is the most common psychiatric disorder that is claimed in compensation claims in Australia. There are currently no reliable means to distinguish malingered from genuine PTSD. This project aims to develop the most accurate means of identifying malingered PTSD by using the most recent technology to index biological responses, including fMRI, in participants with PT ....Identifying Malingered Posttraumatic Stress Disorder: Biological Markers for Legal Assessment. Posttraumatic stress disorder (PTSD) is the most common psychiatric disorder that is claimed in compensation claims in Australia. There are currently no reliable means to distinguish malingered from genuine PTSD. This project aims to develop the most accurate means of identifying malingered PTSD by using the most recent technology to index biological responses, including fMRI, in participants with PTSD, without PTSD, and malingered PTSD. This study will lead to a biological assessment that can objectively index PTSD and be resistant to intentional feigning. These data will significantly enhance legal assessments of PTSD and facilitate compensation resolution.Read moreRead less
A Cognitive And Neuroimaging Study Of Exceptionally Old Individuals: Sydney Centenarian Study
Funder
National Health and Medical Research Council
Funding Amount
$857,197.00
Summary
Australia has an ageing society. Individuals over the age of 95 years are the fastest growing proportion of this population. Many of these individuals retain good cognitive function. The Sydney Centenarian Study will recruit all individuals 95 and over in 7 local government areas in Sydney to assess their brain function to determine which cognitive faculties are more or less affected, and how this relates to changes on brain scans. This will be related to neuropathology.
Discovery Early Career Researcher Award - Grant ID: DE130100868
Funder
Australian Research Council
Funding Amount
$336,284.00
Summary
Neural mechanisms of inhibitory control of human speech in stutterers and non-stutterers. Stopping oneself from speaking is a crucial communication function. In people who stutter, a disorder of this function causes their debilitating speech problem. This project will use cutting edge neuroimaging techniques to reveal how the brain stops speech in stutterers and in fluent speakers.
Unconscious processing: To what extent, how flexible and how smart? We are unaware of the sophisticated pattern analyses conducted by our perceptual systems that enable us to operate in a complex environment. Less clear is whether unconsciously presented information itself can influence our behaviour or indeed whether unconscious cognition occurs. The proposed studies provide the foundation and structure for a pioneering examination of the extent, flexibility and computational power of unconscio ....Unconscious processing: To what extent, how flexible and how smart? We are unaware of the sophisticated pattern analyses conducted by our perceptual systems that enable us to operate in a complex environment. Less clear is whether unconsciously presented information itself can influence our behaviour or indeed whether unconscious cognition occurs. The proposed studies provide the foundation and structure for a pioneering examination of the extent, flexibility and computational power of unconscious processing at the level of neural response and behaviour. The impact and benefits of the project will be in its contribution to theory with outcomes revealing the boundary conditions governing unconscious cognition and providing a first benchmark for how such conditions might vary across the lifespan.Read moreRead less
The Structural Basis For Glutamate Transporter Function
Funder
National Health and Medical Research Council
Funding Amount
$373,144.00
Summary
Glutamate transporters are vacuum cleaners in the brain that suck the neurotransmitter glutamate into cells. When the glutamate vacuum breaks down or becomes blocked, glutamate levels outside cells increase, leading to cell death in the brain. This process underlies the damage in many brain diseases including Alzheimer’s disease and stroke. The aim of this project is to understand the mechanism of the glutamate vacuum cleaner so we can develop therapeutics to fix it when it breaks down.
Brain mechanisms for coordinating with others through sound. Distinguishing between sounds produced by self and others is critical for interpersonal coordination and communication through speech and music. This project employs a novel dual-brain electrophysiological technique with tagged audio signals to elucidate how the human brain achieves this distinction, and when and why it cannot. Expected outcomes include new knowledge on the neurophysiological mechanisms that support self-other processi ....Brain mechanisms for coordinating with others through sound. Distinguishing between sounds produced by self and others is critical for interpersonal coordination and communication through speech and music. This project employs a novel dual-brain electrophysiological technique with tagged audio signals to elucidate how the human brain achieves this distinction, and when and why it cannot. Expected outcomes include new knowledge on the neurophysiological mechanisms that support self-other processing, and the acoustic conditions and behavioural strategies that facilitate their operation. These outcomes should ultimately have applied benefits for improving interpersonal coordination and social interaction, especially in digital environments and clinical populations with atypical self-other processing.Read moreRead less
Tracking the Flow of Perceptual Information Through Decision Networks. The choices we make define our lives. Despite exciting progress in neuroscience, we still don’t know how the inner workings of the brain give rise to simple decisions. This project brings together experts from diverse domains of computational neuroscience to investigate how our brains turn perceptual information into action. Together, we will develop new methods to track information flow through the brain during the decision ....Tracking the Flow of Perceptual Information Through Decision Networks. The choices we make define our lives. Despite exciting progress in neuroscience, we still don’t know how the inner workings of the brain give rise to simple decisions. This project brings together experts from diverse domains of computational neuroscience to investigate how our brains turn perceptual information into action. Together, we will develop new methods to track information flow through the brain during the decision making process. By doing so, we will develop a world-leading model of how the brain makes decisions, and also provide the broader scientific community with a set of exciting new tools for studying information processing in the brain.Read moreRead less