Long-term Cloud Service Composition. This project proposes an economic model-based framework for the selection and composition of cloud services, thus creating an efficient market for cloud consumers and providers. The project will use economic models that incorporate a range of quality of service (QoS) parameters as a key driver for optimising the selection of cloud services and the acceptance of consumer requests. The main outcomes of this project aim to increase efficiencies in the cloud mark ....Long-term Cloud Service Composition. This project proposes an economic model-based framework for the selection and composition of cloud services, thus creating an efficient market for cloud consumers and providers. The project will use economic models that incorporate a range of quality of service (QoS) parameters as a key driver for optimising the selection of cloud services and the acceptance of consumer requests. The main outcomes of this project aim to increase efficiencies in the cloud market, benefiting consumers and providers.Read moreRead less
Data Mining by Clustering in Very Large Relational Databases. Many commercial and governmental entities possess very large relational data that cannot be feasibly analyzed by today's computers, e.g., gene expression data, product usage databases and telecommunication call records. The clustering tools developed in this project will have a significant benefit on many business processes that involve clustering this type of data, such as fraud detection and market segmentation.
Using Stem Cells And Bioengineered Scaffolds To Promote Regeneration Following Necrotic Brain Injury
Funder
National Health and Medical Research Council
Funding Amount
$710,857.00
Summary
A number of injuries, including stroke, result in tissue loss. Consequently promoting repair will require restoration of tissue structure, replacement cells and a supportive environment to promote integration of these new cells. This study will engineer and develop novel scaffolds that can replace tissue whilst additionally providing physical and chemical support for newly implanted stem cells. This work will be conducted in an animal model of stroke.
Standardising Protocols For The Differentiation And Integration Of Human Pluripotent Stem Cell-derived Neural Transplants In Parkinson's Disease
Funder
National Health and Medical Research Council
Funding Amount
$987,664.00
Summary
Clinical trials have shown that transplanting dopamine neurons (specific nerve cells) into the brain of Parkinson’s disease patients can improve symptoms. Trials use fetal tissue for implantation, which is unsustainable and highly variable. This proposal will examine stem cells as an alternative. We will establish a reliable protocol to instruct human stem cells to become dopamine neurons, develop methods to select these cells and, examine the integration of these transplanted cells in the brain
Improving Legal Frameworks to Support Online Child Sex Abuse Prosecutions. This project aims to gain a deeper understanding of the nature and extent of online child sexual abuse prosecutions in Australia. Using empirical studies to draw on the practical experience of law enforcement and other stakeholders, it will generate new knowledge concerning the suitability of Australia's legal and policy frameworks to effectively investigate and prosecute such offences, with a particular focus on the Asia ....Improving Legal Frameworks to Support Online Child Sex Abuse Prosecutions. This project aims to gain a deeper understanding of the nature and extent of online child sexual abuse prosecutions in Australia. Using empirical studies to draw on the practical experience of law enforcement and other stakeholders, it will generate new knowledge concerning the suitability of Australia's legal and policy frameworks to effectively investigate and prosecute such offences, with a particular focus on the Asia-Pacific region and the use of new technologies. Expected outcomes include evidence-based recommendations on criminal law reform and enforcement policy that aim to improve the international enforcement of online child sexual abuse offences, and to provide a model for other forms of serious transnational online crime.Read moreRead less
Knowledge, Identification And Exploitation Of Dopaminergic Axon Guidance Cues Will Improve Cell Replacement Therapy For ParkinsonÍs Disease.
Funder
National Health and Medical Research Council
Funding Amount
$481,797.00
Summary
Many obstacles exist for cell transplantation in ParkinsonÍs Disease; namely poor graft survival, restoration of appropriate circuitry and adequate nerve fiber growth from new cells. Using knowledge of how neural circuits are established during fetal development, we will attempt to recapitulate these events following transplantation. Further, we will identify new and novel cues in regulating the connectivity and growth of these nerve fibers.
An integrated and real-time passenger travel and public transport service information system. This project will help the Department of Transport provide improved services to the public through a better understanding of journey planning demands in comparison to public transport services. By integrating research through design methods with technological solutions, the project will deliver better quality of service and higher customer satisfaction.
Regulation Of Neural Progenitor Cell Self-renewal By The RNA-binding Protein ZFP36L1 During Development And Disease
Funder
National Health and Medical Research Council
Funding Amount
$345,401.00
Summary
The timely differentiation of neural stem cells is critical during development, and the unrestrained proliferation of neural stem cells in the adult can lead to deadly brain cancers such as glioma. At present our understanding of the key molecules that regulate neural stem cell behaviour during these processes remains limited. In this proposal we will investigate the molecular determinants underpinning neural stem cell biology, both within the developing brain, and within glioma.
Engineering evolving complex network systems through structure intervention. This project aims to create a theory and technology for engineering complex network systems (CSS) through structural intervention. Complex network systems with evolving components are ubiquitous in nature and society. The science of biological networks, the Internet and large-scale power networks demand tools to understand and influence their evolving dynamics. This project could result in a breakthrough theory in netwo ....Engineering evolving complex network systems through structure intervention. This project aims to create a theory and technology for engineering complex network systems (CSS) through structural intervention. Complex network systems with evolving components are ubiquitous in nature and society. The science of biological networks, the Internet and large-scale power networks demand tools to understand and influence their evolving dynamics. This project could result in a breakthrough theory in network science and technology to augment biological systems and power grids. Expected benefits include cost-effective augmentation of power networks injected with renewable energy sources, and advancing basic biology research.Read moreRead less
Emergence of robust, stable structures via computation within natural networks. An ever-increasing challenge for modern society is the sheer complexity of vast infrastructures. Unexpected, and sometimes catastrophic, behaviour often emerges from interactions between elements of large systems. As a result, highly complex systems such as the Internet, international finance markets, and power grids are highly susceptible to costly problems such as cascading failures, inefficiency, and critical sens ....Emergence of robust, stable structures via computation within natural networks. An ever-increasing challenge for modern society is the sheer complexity of vast infrastructures. Unexpected, and sometimes catastrophic, behaviour often emerges from interactions between elements of large systems. As a result, highly complex systems such as the Internet, international finance markets, and power grids are highly susceptible to costly problems such as cascading failures, inefficiency, and critical sensitivity. High-tech industries, such as biotechnology and information networking, also face problems in coordinating swarms of interacting agents. This project will contribute to solving such problems by identifying and adapting solutions from nature.Read moreRead less