Benchmarking the neurophysiology of human cortex models in vitro. This project aims to improve human brain models in vitro by developing an analytical tool benchmarking biophysical similarities to the adult human cortex. This project expects to generate new knowledge by testing for the first time the theory that integrating sensory-like inputs and awake/sleep-like cycles of electrical activity in vitro may complete the maturation of human brain organoid models. It will also generate new methods ....Benchmarking the neurophysiology of human cortex models in vitro. This project aims to improve human brain models in vitro by developing an analytical tool benchmarking biophysical similarities to the adult human cortex. This project expects to generate new knowledge by testing for the first time the theory that integrating sensory-like inputs and awake/sleep-like cycles of electrical activity in vitro may complete the maturation of human brain organoid models. It will also generate new methods to simplify the analysis of multimodal path-clamping data (Patch-seq). Expected outcomes will facilitate research collaboration and the reproducibility of accurate experimental replicates of the human brain. This will provide significant benefits in the global race to understand human brain computation mechanisms.Read moreRead less
Organic Bionics: Soft Materials to Solve Hard Problems in Neuroengineering. This project aims to combine innovations in organic conductors, nanotechnology, 3D biofabrication and neuroengineering to develop a bioelectronic system capable of wireless neuromodulation with unprecedented stability and precision. This project expects to generate new knowledge regarding the properties of materials that promote optical neuromodulation and new strategies to obtain long-term material stability in biologic ....Organic Bionics: Soft Materials to Solve Hard Problems in Neuroengineering. This project aims to combine innovations in organic conductors, nanotechnology, 3D biofabrication and neuroengineering to develop a bioelectronic system capable of wireless neuromodulation with unprecedented stability and precision. This project expects to generate new knowledge regarding the properties of materials that promote optical neuromodulation and new strategies to obtain long-term material stability in biological environments. The expected outcome is to generate new material design rules to facilitate wireless neuromodulation technologies in biomedical engineering. The project will position Australia as a leader in bionic devices by creating a new 3D bioprinting hub for low-cost fabrication of bioelectronic systems.Read moreRead less
A novel and efficient approach for optimisation involving iterative solvers. Computationally expensive simulations involving iterative solvers are increasingly being used in industry to assess performance of products and processes. Repeated use of such simulations is necessary to identify optimum solutions. Even with today's computing power, many such tasks remain computationally prohibitive. This project presents a novel approach to solve optimisation problems involving iterative solvers with l ....A novel and efficient approach for optimisation involving iterative solvers. Computationally expensive simulations involving iterative solvers are increasingly being used in industry to assess performance of products and processes. Repeated use of such simulations is necessary to identify optimum solutions. Even with today's computing power, many such tasks remain computationally prohibitive. This project presents a novel approach to solve optimisation problems involving iterative solvers with limited computing budget. A wide range of industries involved in product and process design would gain a significant competitive advantage from this unique technical innovation. In addition, this technology will be invaluable to uncover and understand complex natural phenomena.Read moreRead less
Evolutionary computation for expensive bilevel multiobjective problems. This project aims to develop an evolutionary computation framework to solve computationally expensive bilevel multiobjective problems. The research is fundamental in nature and will address key open challenges in solving such problems, including hierarchical decision-making, multiple performance criteria, uncertainties and computational expense. The proposed research has applications in diverse domains such as environmental ....Evolutionary computation for expensive bilevel multiobjective problems. This project aims to develop an evolutionary computation framework to solve computationally expensive bilevel multiobjective problems. The research is fundamental in nature and will address key open challenges in solving such problems, including hierarchical decision-making, multiple performance criteria, uncertainties and computational expense. The proposed research has applications in diverse domains such as environmental policy formulation, network design, engineering, defence and cybersecurity; offering significant benefits to the researchers and practitioners in these fields. In addition to research outputs, it will strengthen international collaboration and build research capacity to put Australia at the forefront of this research.
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Evolutionary computation for robust multi-objective engineering design. This project aims to develop an evolutionary computation framework for robust multi-objective design, a critical pursuit in engineering industries. Such problems are characterised by multiple conflicting performance objectives
and constraints which are highly nonlinear, often black-box, and prone to unavoidable real-life uncertainties. The existing evolutionary algorithms are often computationally impractical and have a numb ....Evolutionary computation for robust multi-objective engineering design. This project aims to develop an evolutionary computation framework for robust multi-objective design, a critical pursuit in engineering industries. Such problems are characterised by multiple conflicting performance objectives
and constraints which are highly nonlinear, often black-box, and prone to unavoidable real-life uncertainties. The existing evolutionary algorithms are often computationally impractical and have a number of fundamental
shortcomings which restrict their use in real applications. This project aims to investigate and overcome the underlying key challenges to advance knowledge and contribute towards diverse domains such as energy, transport and space research, helping deliver high quality robust designs.
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Learning deep resilient behaviour for uncertainty-aware autonomy. This research project aims to propose a novel framework for developing uncertainty-aware autonomous systems using deep learning. There are fundamental gaps in our knowledge of deep uncertainty quantification and its application for risk-aware decision making. Novel algorithms will be proposed to reliably generate deep uncertainty estimates with low computational overhead. These estimates will be then exploited by safety-critical s ....Learning deep resilient behaviour for uncertainty-aware autonomy. This research project aims to propose a novel framework for developing uncertainty-aware autonomous systems using deep learning. There are fundamental gaps in our knowledge of deep uncertainty quantification and its application for risk-aware decision making. Novel algorithms will be proposed to reliably generate deep uncertainty estimates with low computational overhead. These estimates will be then exploited by safety-critical systems such as autonomous robots to identify risky actions and avoid catastrophise. Developed algorithms will be implemented on an autonomous robotic system to make it averse to uncertainties. The outcomes will greatly increase reliable telerobotic applications in mining, manufacturing, defence, and health.Read moreRead less
Cyber-Physical Security Analyses and Enhancing the Resilience of Smart Grid. The electrical power industry in Australia is undergoing a massive revolution to an intelligent, low-carbon and sustainable smart grid environment. However, due to the heavy reliance on cyber infrastructure and the intermittence of renewables, smart grid will inevitably introduce new security issues, for example, cyber security. This project is to investigate emerging security issues together in a comprehensive framewor ....Cyber-Physical Security Analyses and Enhancing the Resilience of Smart Grid. The electrical power industry in Australia is undergoing a massive revolution to an intelligent, low-carbon and sustainable smart grid environment. However, due to the heavy reliance on cyber infrastructure and the intermittence of renewables, smart grid will inevitably introduce new security issues, for example, cyber security. This project is to investigate emerging security issues together in a comprehensive framework where quantitative models and analysis methods will be explored for smart grid cascading failure analyses. Then innovative three-stage reinforcement strategies (three lines of defence) will be developed to enhance the resilience of smart grid against natural disasters and intentional attacks, and potential large blackouts. Read moreRead less
The neural dynamics of real-time processing in the brain. The aim of this project is to investigate a new model for predictive coding of sensory processing in the brain in which the brain compensates for the time delays in neural transmission by maintaining a real-time temporal alignment of the neural activity. This results in a representation of sensory information that is aligned in time across the cortex, offering a new fundamental principle for how the brain functions in a highly dynamic wor ....The neural dynamics of real-time processing in the brain. The aim of this project is to investigate a new model for predictive coding of sensory processing in the brain in which the brain compensates for the time delays in neural transmission by maintaining a real-time temporal alignment of the neural activity. This results in a representation of sensory information that is aligned in time across the cortex, offering a new fundamental principle for how the brain functions in a highly dynamic world whose outcomes would provide a deeper understanding of brain function. It could also have profound significance for artificial intelligence and brain-inspired technologies, as well as benefit neural sensory prostheses and brain-machine interfaces.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE210101623
Funder
Australian Research Council
Funding Amount
$456,450.00
Summary
High-Fidelity Motion Simulator using Sickness-Free Motion Cueing Algorithm. This project aims to address the key deficiencies of driving and flight simulators by developing novel human perception-based motion cueing algorithms (MCAs) and leveraging advanced artificial intelligence techniques. Despite widespread applications, existing motion simulators fail to deliver the most accurate human sensation to the user. This failure is mainly attributable to the inefficiency and inflexibility of MCAs u ....High-Fidelity Motion Simulator using Sickness-Free Motion Cueing Algorithm. This project aims to address the key deficiencies of driving and flight simulators by developing novel human perception-based motion cueing algorithms (MCAs) and leveraging advanced artificial intelligence techniques. Despite widespread applications, existing motion simulators fail to deliver the most accurate human sensation to the user. This failure is mainly attributable to the inefficiency and inflexibility of MCAs used by simulators. It is expected that this project will significantly increase simulator motion fidelity and eliminate motion sickness. This will have substantial benefits to Australian research communities and industries, particularly where simulators are used for training, performance evaluation and virtual prototyping.Read moreRead less
Modelling and manipulating brain network dynamics across the lifespan. This project aims to integrate advanced computational modelling and state-of-the-art recording techniques to generate new knowledge on the neural basis of ageing. People are said to grow wiser as they grow older, though more likely they will experience cognitive slowing and reduced memory functions that interfere with their daily lives. The anticipated goal of the project is to develop techniques to predict the personalised e ....Modelling and manipulating brain network dynamics across the lifespan. This project aims to integrate advanced computational modelling and state-of-the-art recording techniques to generate new knowledge on the neural basis of ageing. People are said to grow wiser as they grow older, though more likely they will experience cognitive slowing and reduced memory functions that interfere with their daily lives. The anticipated goal of the project is to develop techniques to predict the personalised effects of brain stimulation on the ageing brain. The outcomes of this research could significantly improve understanding of brain ageing, and advance the fields of systems neuroscience, network science, and brain stimulation.Read moreRead less