Discovery Early Career Researcher Award - Grant ID: DE170101514
Funder
Australian Research Council
Funding Amount
$372,000.00
Summary
The control of neuroplasticity in the brain. This project aims to determine how neuroplasticity – the brain’s ability to remodel and make new circuits – is controlled in both excitatory and inhibitory neurons. This capacity, vital for all cognitive functions, diminishes as people age. It is imperative to determine neuroplasticity’s mechanisms and how and why they change, but it is not known how both excitatory and inhibitory neurons contribute to neuroplasticity and how these dynamic alterations ....The control of neuroplasticity in the brain. This project aims to determine how neuroplasticity – the brain’s ability to remodel and make new circuits – is controlled in both excitatory and inhibitory neurons. This capacity, vital for all cognitive functions, diminishes as people age. It is imperative to determine neuroplasticity’s mechanisms and how and why they change, but it is not known how both excitatory and inhibitory neurons contribute to neuroplasticity and how these dynamic alterations are controlled. Understanding neuroplasticity is vital for learning, memory and healthy ageing throughout life.Read moreRead less
Special Research Initiatives - Grant ID: SR0567321
Funder
Australian Research Council
Funding Amount
$184,781.00
Summary
Real-time Very Long Baseline Interferometry. We will develop a range of software products that are required to implement real-time very long baseline interferometry with the Australia long baseline array. These developments build upon substancial recent infrastructure investments and will place Australia at the forefront of this field. They will enhance our capacity to participate in international collaborations in a range of sciences including astrophysics, spacecraft tracking and geodetic mo ....Real-time Very Long Baseline Interferometry. We will develop a range of software products that are required to implement real-time very long baseline interferometry with the Australia long baseline array. These developments build upon substancial recent infrastructure investments and will place Australia at the forefront of this field. They will enhance our capacity to participate in international collaborations in a range of sciences including astrophysics, spacecraft tracking and geodetic monitoring.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0561104
Funder
Australian Research Council
Funding Amount
$402,128.00
Summary
A 10 Gbit/s Fibre Optic link to the Mt Pleasant and Mt Canopus Observatories. A 10 gigabit per second fibre optic link to the Mt Pleasant and Mt Canopus observatories will enable a wide range of new and exciting research opportunities. Very long baseline interferometry (VLBI) allows imaging of distant astronomical objects with much higher resolution than any other technique. The proposed fibre optic link will revolutionise Australia's VLBI capability, giving it the world's most sensitive array, ....A 10 Gbit/s Fibre Optic link to the Mt Pleasant and Mt Canopus Observatories. A 10 gigabit per second fibre optic link to the Mt Pleasant and Mt Canopus observatories will enable a wide range of new and exciting research opportunities. Very long baseline interferometry (VLBI) allows imaging of distant astronomical objects with much higher resolution than any other technique. The proposed fibre optic link will revolutionise Australia's VLBI capability, giving it the world's most sensitive array, with enhanced reliability and faster access to results for researchers. This project will greatly facilitate studies of astrophysical processes in Galactic and extra-galactic environments as well as precision measurements of the Earth's crustal dynamics.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE180100245
Funder
Australian Research Council
Funding Amount
$386,500.00
Summary
Achieving millimetre geodesy with space tie satellites. This project aims to implement the completely new concept of observing artificial satellites with radio telescopes, realising a so-called space tie. Understanding Earth’s changing shape requires measurements with a stability of 0.1 mm per year. Today, geodetic earth observations are used to realise reference points with a precision of five to ten times larger. Using the unique Australian ground infrastructure, current observational and oper ....Achieving millimetre geodesy with space tie satellites. This project aims to implement the completely new concept of observing artificial satellites with radio telescopes, realising a so-called space tie. Understanding Earth’s changing shape requires measurements with a stability of 0.1 mm per year. Today, geodetic earth observations are used to realise reference points with a precision of five to ten times larger. Using the unique Australian ground infrastructure, current observational and operational problems shall be overcome. The intended outcome is to improve the coordinate system of the Earth, which is the basis for a better understanding of Earth serving to fulfil scientific as well as societal demands.Read moreRead less
Ring constructions and algorithms for enhancing performance of BCH codes. BCH codes form a major class of codes used in modern communication systems. The aim of this project is to enhance the efficiency of this class of codes by combining them in constructions enabling correction of deletion and insertion errors, and develop efficient implementations of encoding and decoding algorithms incorporating soft decision methods for enhanced error correction. Significance of the project is explained by ....Ring constructions and algorithms for enhancing performance of BCH codes. BCH codes form a major class of codes used in modern communication systems. The aim of this project is to enhance the efficiency of this class of codes by combining them in constructions enabling correction of deletion and insertion errors, and develop efficient implementations of encoding and decoding algorithms incorporating soft decision methods for enhanced error correction. Significance of the project is explained by the role of fast, secure and reliable communications in modern information and communication technology. Expected outcomes include new efficient algorithms and commercial modules available for symbolic computation systems with applications in telecommunications industry.
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Discovery Early Career Researcher Award - Grant ID: DE220100265
Funder
Australian Research Council
Funding Amount
$417,000.00
Summary
A closed-loop human–agent learning framework to enhance decision making. This project aims to design a foundational human–agent learning framework to augment the decision making process, using reinforcement and closed-loop mechanisms to enable symbiosis between a human and an artificial-intelligence agent. It envisages significant new technologies to promote controllability and efficient and safe exploration of an environment for decision actions – drastically boosting learning effectiveness and ....A closed-loop human–agent learning framework to enhance decision making. This project aims to design a foundational human–agent learning framework to augment the decision making process, using reinforcement and closed-loop mechanisms to enable symbiosis between a human and an artificial-intelligence agent. It envisages significant new technologies to promote controllability and efficient and safe exploration of an environment for decision actions – drastically boosting learning effectiveness and interpretability in decision making. Expected outcomes will benefit national cybersecurity by improving our understanding of vulnerabilities and threats involving decision actions, and by ensuring that human feedback and evaluations can help prevent catastrophic events in explorations of dynamic and complex environments.Read moreRead less
The role of turgor in hyphal extension of the Ascomycete Neurospora crassa. Cellular expansion is an absolute necessity during the growth and development of plants and fungi. This process relies heavily upon the accumulation of inorganic ions. Osmotically driven water influx then creates the hydrostatic pressure that underlies the increase in cell volume. Cellular expansion is normally asymmetric and localised in one small region, such as hyphal tip. How does the cell maintain the turgor that dr ....The role of turgor in hyphal extension of the Ascomycete Neurospora crassa. Cellular expansion is an absolute necessity during the growth and development of plants and fungi. This process relies heavily upon the accumulation of inorganic ions. Osmotically driven water influx then creates the hydrostatic pressure that underlies the increase in cell volume. Cellular expansion is normally asymmetric and localised in one small region, such as hyphal tip. How does the cell maintain the turgor that drives expansion? How is expansion controlled spatially? These questions will be addressed in this project by comprehensive study of ion transport processes in a model organism, Neurospora crassa, using osmotic sensitive and transport mutants.Read moreRead less
Visualising neuron-glia interactions in the injured central nervous system. The adult brain and spinal cord recovery poorly from injury. Attempts to overcome this problem include methods to promote the intrinsic regenerative capacity of injured neurons, and modulating the inhibitory extracellular environment to become permissive to regeneration. The goal of this project is to investigate an endogenous regenerative mechanism in the injured brain. This project will use the latest, cutting-edge mic ....Visualising neuron-glia interactions in the injured central nervous system. The adult brain and spinal cord recovery poorly from injury. Attempts to overcome this problem include methods to promote the intrinsic regenerative capacity of injured neurons, and modulating the inhibitory extracellular environment to become permissive to regeneration. The goal of this project is to investigate an endogenous regenerative mechanism in the injured brain. This project will use the latest, cutting-edge microscopy techniques to visualise whether the endogenous astrocyte protein metallothionein can promote regeneration in the injured nervous system of living zebrafish. The successful outcomes of this project will provide significant insight into understanding how the brain responds to injury.Read moreRead less
Investigating the molecular function of alpha-Haemoglobin stabilising protein. The research described in this proposal will provide new insights into haemoglobin regulation and redox chemistry in erythrocytes. Deregulation of these processes gives rise to a number of debilitating diseases, including varieties of anaemia and thalassaemia-in Australia it is estimated that 3% of the population could be carriers of b-thalassaemia mutations. Given the contribution of free aHb to the pathology of b-th ....Investigating the molecular function of alpha-Haemoglobin stabilising protein. The research described in this proposal will provide new insights into haemoglobin regulation and redox chemistry in erythrocytes. Deregulation of these processes gives rise to a number of debilitating diseases, including varieties of anaemia and thalassaemia-in Australia it is estimated that 3% of the population could be carriers of b-thalassaemia mutations. Given the contribution of free aHb to the pathology of b-thalassaemia, understanding the specific aHb-binding factor, AHSP is a goal of national significance. In the long term, manipulation of AHSP function through gene therapy may have a direct role in the treatment of thalassaemia.Read moreRead less
Identifying the specific structural features of metallothionein that regulate its ability to modulate astrogliosis. This project contributes directly to the Designated National Research Priority 2 and could potentially have a significant impact upon the broader Australian Community by identifying a novel and powerful therapeutic agent based upon metallothionein proteins with the ultimate aim of helping patients who have a brain injury or a neurodegenerative disease. It is important to note that ....Identifying the specific structural features of metallothionein that regulate its ability to modulate astrogliosis. This project contributes directly to the Designated National Research Priority 2 and could potentially have a significant impact upon the broader Australian Community by identifying a novel and powerful therapeutic agent based upon metallothionein proteins with the ultimate aim of helping patients who have a brain injury or a neurodegenerative disease. It is important to note that the partnership between UTAS and Bestenbalt LLC is a critical step in the development of these exciting research discoveries into commercially viable outcomes for the Australian Biotechnology Industry and the broader Australian community.Read moreRead less