Mechanical Factors In Normal Human Colonic Motility
Funder
National Health and Medical Research Council
Funding Amount
$650,023.00
Summary
Abnormal human colonic contractions cause significant medical, societal and financial burdens. Diagnosis and treatment of motility disorders requires an understanding of normal colonic contractility against which to measure dysfunction. Through state-of-the-art recording and analytical techniques, developed by the applicants, this project will provide the first clear description of normal human colonic motor patterns and how they are generated.
Brain Repair Following Stroke: The Role Of Npas4, A Neural-specific Transcription Factor
Funder
National Health and Medical Research Council
Funding Amount
$611,053.00
Summary
Stroke is the #1 cause of adult disability in Australia and #2 cause of death. About 60,000 Australians suffer a stroke each year while about 250,000 live with the disabilities of stroke, costing over $2B/year. The Queen Elizabeth Hospital and University of Adelaide will study why the Npas4 gene switches on after stroke and the role it plays in brain repair. Future health benefits may be tests to help improve stroke outcome in patients and therapy to decrease loss of brain cells after stroke.
Bio-inspired Computing for Problems with Dynamically Changing Constraints. The aim of this project is to design bio-inspired computing methods for dynamically changing environments. Dynamic problems arise frequently in the areas of engineering, logistics, and manufacturing. Such problems are usually subject to a large set of constraints that change over time due to changes in resources. Algorithms that can deal with such dynamic changes would benefit decision-makers. The project aims to provide ....Bio-inspired Computing for Problems with Dynamically Changing Constraints. The aim of this project is to design bio-inspired computing methods for dynamically changing environments. Dynamic problems arise frequently in the areas of engineering, logistics, and manufacturing. Such problems are usually subject to a large set of constraints that change over time due to changes in resources. Algorithms that can deal with such dynamic changes would benefit decision-makers. The project aims to provide a foundational theory as the basis for the design of bio-inspired algorithms dealing with dynamically changing constraints and provide approaches for dealing with important industrial problems.Read moreRead less
Computational Intelligence Methods for Financial Applications. Complex financial problems can be better addressed with software that can learn from available data and adapt to environmental changes. It is therefore essential to develop technologies that enable prediction and optimisation in constrained and dynamic environments. There are currently some limitations in existing business decision support systems despite their ubiquity providing an opportunity for Australia to be at the forefront as ....Computational Intelligence Methods for Financial Applications. Complex financial problems can be better addressed with software that can learn from available data and adapt to environmental changes. It is therefore essential to develop technologies that enable prediction and optimisation in constrained and dynamic environments. There are currently some limitations in existing business decision support systems despite their ubiquity providing an opportunity for Australia to be at the forefront as new standards in the field are developed. Furthermore, the fund management industry (particularly superannuation) is significant to the Australian economy and development of this technology has the potential to enhance its performance and reputation.Read moreRead less
Defining The Role Of The Ubiquitin Protein Ligase Nedd4 In Vascular Development.
Funder
National Health and Medical Research Council
Funding Amount
$702,166.00
Summary
Blood and lymphatic vessels are vital components of the cardiovascular system. Abnormalities in the growth and development of these vessels are associated with human disorders including cancer and cardiovascular disease. The focus of this application is to characterise the role of the ubiquitin protein ligase Nedd4 in vascular development, with the aim of identifying targets to which novel therapeutics for the treatment of blood and lymphatic vascular diseases could be generated.
The Analog Mind: Connectionism, Consciousness and Mental Representation. The aim of our project is to explore novel conjectures about the way information is coded and processed in the brain, and the manner in which the brain manufactures consciousness. This work may eventually pay rich dividends by reducing the incidence of mental illnesses, such as schizophrenia, that disturb conscious experience. It may also lead to the development of more powerful forms of computation in artificial neural ne ....The Analog Mind: Connectionism, Consciousness and Mental Representation. The aim of our project is to explore novel conjectures about the way information is coded and processed in the brain, and the manner in which the brain manufactures consciousness. This work may eventually pay rich dividends by reducing the incidence of mental illnesses, such as schizophrenia, that disturb conscious experience. It may also lead to the development of more powerful forms of computation in artificial neural networks. This will have a significant impact on the artificial intelligence industry, with obvious economic benefits for Australia.
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A unified theory of performance in absolute identification tasks. The ability to identify stimuli is fundamentally important in human cognition and is studied in absolute identification tasks, where people must identify one out of a number of stimuli, varying on a single dimension, with an appropriate label. A remarkable finding is that people cannot reliably identify more than about seven different stimuli. This limit imposes severe practical restrictions on our ability to categorise stimuli an ....A unified theory of performance in absolute identification tasks. The ability to identify stimuli is fundamentally important in human cognition and is studied in absolute identification tasks, where people must identify one out of a number of stimuli, varying on a single dimension, with an appropriate label. A remarkable finding is that people cannot reliably identify more than about seven different stimuli. This limit imposes severe practical restrictions on our ability to categorise stimuli and constitutes a perplexing problem for cognitive theory. This project involves an international collaborative effort by five leading researchers in mathematical psychology to develop a comprehensive, integrative model of human performance in absolute identification tasks.
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Parameterized Analysis of Bio-inspired Computing - From Theory to High Performing Algorithms. This project will establish the field of parameterised analysis of bio-inspired computing which includes prominent approaches such as evolutionary algorithms and ant colony optimisation. It will rigorously analyse features of instances of combinatorial optimisation problems and their impact on the runtime behaviour of bio-inspired computing methods. Furthermore, the project will design new bio-inspired ....Parameterized Analysis of Bio-inspired Computing - From Theory to High Performing Algorithms. This project will establish the field of parameterised analysis of bio-inspired computing which includes prominent approaches such as evolutionary algorithms and ant colony optimisation. It will rigorously analyse features of instances of combinatorial optimisation problems and their impact on the runtime behaviour of bio-inspired computing methods. Furthermore, the project will design new bio-inspired computing algorithms that make use of instance features and hardness characteristics. The results will advance the theoretical knowledge of bio-inspired computing, bridge the gap between theory and practice, and provide more powerful algorithms for complex optimisation problems occurring for example in the field of supply chain management for the mining industry.Read moreRead less
Intelligent Resource Allocation Techniques for Next Generation Wireless Mobile Communication Networks. The project will develop radio and network resource allocation techniques to maximise network utilisation and to offer guaranteed Quality of Service (QoS) for multimedia traffic in 3G/4G wireless mobile communication networks. In particular, this work will study the problem of radio channel allocation in wireless IP (Internet protocol) multimedia networks. The project will develop resource allo ....Intelligent Resource Allocation Techniques for Next Generation Wireless Mobile Communication Networks. The project will develop radio and network resource allocation techniques to maximise network utilisation and to offer guaranteed Quality of Service (QoS) for multimedia traffic in 3G/4G wireless mobile communication networks. In particular, this work will study the problem of radio channel allocation in wireless IP (Internet protocol) multimedia networks. The project will develop resource allocation algorithms based on traffic conditions, link qualities and service requirements using statistical traffic models, mobile software agents and neural network techniques.
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Heterodensity neuroimaging techniques for spatiotemporal identification and localization. Australia is at the forefront of research that is taking brain imaging and interfacing out of the lab and into the field. The technology being developed is spawning applications in areas as diverse as health, education, defense and national security, and will lead to resolution of longstanding theoretical debates as well as enabling new breakthroughs in understanding the biological concomitants of psycholo ....Heterodensity neuroimaging techniques for spatiotemporal identification and localization. Australia is at the forefront of research that is taking brain imaging and interfacing out of the lab and into the field. The technology being developed is spawning applications in areas as diverse as health, education, defense and national security, and will lead to resolution of longstanding theoretical debates as well as enabling new breakthroughs in understanding the biological concomitants of psychological function. This is significant given the push to develop biometrics of psychological function with enhanced sensitivity and specificity in clinical diagnosis, along with defense applications in evaluation of critical personnel and training. It also opens up a range of applications for mental control of remote or prosthetic devices.Read moreRead less