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Assessing The Impact Of Climate Change On The Transmission Of Mosquito-borne Diseases In Australia
Funder
National Health and Medical Research Council
Funding Amount
$346,689.00
Summary
Global climate change has potentially serious effects on the transmission of mosquito-borne diseases (MBDs). Bayesian spatiotemporal models will be developed to explore the underlying mechanisms of the current distribution of MBDs and to forecast future changes in pattern of these diseases. The model will be useful in examining where and when MBDs are likely to occur and how the future MBDs control strategies and prevention efforts need to be applied and strengthened in Australia.
Immunological Changes During Pregnancy And The Impact On Viral Hepatitis Infection
Funder
National Health and Medical Research Council
Funding Amount
$353,355.00
Summary
Hepatitis B virus (HBV) can cause long term health problems particularly affecting the liver and can be passed from mother to baby. Despite the availability of a HBV vaccine babies can still become infected. During pregnancy there are changes in a woman’s immune system which may impact on HBV infection and make transmission to the baby more likely. This research aims to explore the changes in a woman’s immune system and the impact this has on risks for hepatitis and transmission to the baby.
Hepatitis C infection can be cured by using highly effective, simple, recently developed medications. This fellowship will explore new modes of delivering hepatitis C treatment outside of traditional hospital clinics. It will also explore the potential for successful treatment to prevent transmission of the hepatitis C. The fellowship will involve the first clinical trial of its type, along with modelling the benefits and cost-effectiveness of treatment and prevention.
Fetal Immune Response To Vertical Transmission Of Toxoplasma Gondii
Funder
National Health and Medical Research Council
Funding Amount
$320,891.00
Summary
Toxoplasma gondii is a parasite that is a leading cause of human abortion and congenital infections of newborns. In addition, recent research implicates Toxoplasma in diagnoses of schizophrenia and other neuromental conditions. Study of Toxoplasma, it's transmission and effects of infection and development of tools such as vaccines and diagnostic technologies will lead to an improvement in health of mothers, newborns and the wider population.
Regulation Of Synaptic Vesicle Biogenesis For Synaptic Transmission
Funder
National Health and Medical Research Council
Funding Amount
$339,115.00
Summary
The overall aim is to better understand the molecular processes of nerve cell communication during learning, memory and abnormal brain activity that cause neurological diseases. The supply and generation (biogenesis) of synaptic vesicles (SVs) in nerve cells is critical to sustain neurotransmission. It requires complex protein interactions and signalling. Thus modulation of SV biogenesis at the molecular level will allows future development of new targeted treatments for neurological diseases.
Fundamental Advancement Of Knowledge Of Plasmodium Vivax Biology, Drug Susceptibility And Transmission
Funder
National Health and Medical Research Council
Funding Amount
$316,067.00
Summary
Plasmodium vivax is the most widespread malaria parasite causing over 80 million cases per year. Yet, current means to counter this parasite are grossly inadequate. Vast knowledge gaps exist due to unavailability of continuous cultures, high throughput drug assays and the poor understanding of transmission. This inhibits the development of new treatments for P. vivax. This project will fundamentally advance knowledge of the biology and epidemiology of this important, but neglected pathogen.