The Role Of The Zinc Finger Transcriptional Repressor Znf238 During Nerve Cell Maturation
Funder
National Health and Medical Research Council
Funding Amount
$394,264.00
Summary
Proper foetal brain assembly is critical for brain function, but the underlying genetic mechanisms remain poorly defined. In this study, I will investigate a family of proteins that “turn on” neural gene expression in combination with another protein that “turns off” their expression during nerve cell development. Understanding this novel on/off mechanism for controlling gene expression in newborn nerve cells will further our understanding of how the brain is assembled.
The Molecular Basis For Target Selection In The Central Nervous System By Sensory Axons
Funder
National Health and Medical Research Council
Funding Amount
$251,325.00
Summary
The normal function of the brain depends upon the specific connections that nerve cells make with each other. These connections are set up in the developing embryo when nerve cells send out long processes - axons - which grow towards their synaptic targets. How axons select their correct targets from amongst the millions of alternatives in the developing brain is unknown. A better understanding of this problem will help us develop therapies to assist regenerating axons re-establish correct conne ....The normal function of the brain depends upon the specific connections that nerve cells make with each other. These connections are set up in the developing embryo when nerve cells send out long processes - axons - which grow towards their synaptic targets. How axons select their correct targets from amongst the millions of alternatives in the developing brain is unknown. A better understanding of this problem will help us develop therapies to assist regenerating axons re-establish correct connections following injury to the brain or spinal cord. We propose to use a simple model system, the embryo of the fruitfly Drosophila, to find molecules that are involved in this process of neuron target recognition - ' axon targeting' molecules - and to study how they work. Drosophila can be genetically manipulated in ways not possible in higher animals. Furthermore the simplicity of its nervous system means that we can determine the connections of individual nerve cells with a high degree of precision. In the first part of our project, we will examine Drosophila embryos that carry mutations in genes suspected to code for targeting molecules. We will stain individual sensory nerve cells in these embryos with dyes to reveal the anatomy of their axons in the brain. If sensory axons terminate abnormally in the brain of a given mutant, the affected gene is likely to code for an axon targeting molecule. In the second part of the study, we will investigate the functions of candidate axon targeting molecules using two approaches. Firstly, we will seek to determine whether the molecule acts in the sensory axons or in their target cells. Secondly, we will use time-lapse microscopy to study how the homing behaviour of the sensory axons is affected in mutant embryos. The results of these studies will lead us closer to an answer to the question: How do axons recognise their specific target cells in the brain?Read moreRead less
Maid in China: Gendered Mobilities, Internal Migration, and the Translocal Imagination. Internal migration always restructures the spatial imagination, and variably across different social groups. In China, gender, class and power relations are important determinants of both mobility and concepts of place. Studying the phenomenon of the migrant baomu (the domestic maid), this project hypothsises that the emerging translocal practices of rural-urban migrants have significantly reworked the spatia ....Maid in China: Gendered Mobilities, Internal Migration, and the Translocal Imagination. Internal migration always restructures the spatial imagination, and variably across different social groups. In China, gender, class and power relations are important determinants of both mobility and concepts of place. Studying the phenomenon of the migrant baomu (the domestic maid), this project hypothsises that the emerging translocal practices of rural-urban migrants have significantly reworked the spatial imagination of the Chinese people. This project will lead to a new conceptualisation of place and space, with the flow of people and the flow of media images brought into productive interface. It will also generate important cross-cultural perspectives on women, work and migration. Research findings will be communicated in a book, Maid in China.Read moreRead less
Refugees and Employment: Exploring the Effects of Visible Difference on Discrimination. This project investigates the impact of ?visible difference? (racial, religious, language) on the success of refugee resettlement in Australia, as measured by employment outcomes. Employment is a major factor determining positive resettlement, yet according to available data, our own research in progress, and anecdotal evidence, unsatisfactory employment outcomes are widespread among refugee communities (DIMI ....Refugees and Employment: Exploring the Effects of Visible Difference on Discrimination. This project investigates the impact of ?visible difference? (racial, religious, language) on the success of refugee resettlement in Australia, as measured by employment outcomes. Employment is a major factor determining positive resettlement, yet according to available data, our own research in progress, and anecdotal evidence, unsatisfactory employment outcomes are widespread among refugee communities (DIMIA 2002; Jupp 2001). However, few studies have been undertaken to explore this. Using a combination of qualitative and quantitative methodologies, the research looks at barriers and facilitators to successful employment outcomes for refugees, from the point of view of refugees and employers. Results will be fed back to employers, employer agencies, refugee communities and government.Read moreRead less
Special Research Initiatives - Grant ID: SR0354802
Funder
Australian Research Council
Funding Amount
$40,000.00
Summary
Migration and its socio-economic and cultural consequences in Australia. This network will develop an interdisciplinary multi-layered approach to understanding migration processes and the related social, health and economic effects. With the input of scholars in diverse fields, the network will play a significant role in the development of a national migration database, in training early career researchers and in developing social policy. It will also stimulate new areas of research, integrate t ....Migration and its socio-economic and cultural consequences in Australia. This network will develop an interdisciplinary multi-layered approach to understanding migration processes and the related social, health and economic effects. With the input of scholars in diverse fields, the network will play a significant role in the development of a national migration database, in training early career researchers and in developing social policy. It will also stimulate new areas of research, integrate the dynamics of migrant populations with migrants' own experiences and perceptions, add to knowledge in the priority area 'safeguarding Australia', and enhance our understanding of the cultural, social and economic impact on Australia of a significant migrant presence.Read moreRead less
Exposure to workplace hazards among migrant workers in Australia. This project aims to compare the prevalence of exposure to workplace hazards, namely carcinogens and psychosocial risk factors (eg bullying and precarious work), among migrant and Australian-born workers. The international literature suggests that migrant workers are exposed to more workplace hazards than native-born populations, but the evidence base for Australia is patchy despite the fact that Australia has such a large migrant ....Exposure to workplace hazards among migrant workers in Australia. This project aims to compare the prevalence of exposure to workplace hazards, namely carcinogens and psychosocial risk factors (eg bullying and precarious work), among migrant and Australian-born workers. The international literature suggests that migrant workers are exposed to more workplace hazards than native-born populations, but the evidence base for Australia is patchy despite the fact that Australia has such a large migrant population. The anticipated goal of this project is to address this gap in evidence. The intended outcomes are the necessary first step in the process of reducing exposure to harmful substances and behaviours for all workers.Read moreRead less
Reducing health disparities for culturally and linguistically diverse peoples. This project aims to develop a greater understanding of migrants and the factors that predict poor health outcomes related to blood-borne viruses and sexually transmitted infections. The delayed access by migrants to healthcare from culturally and linguistically diverse backgrounds results in late diagnosis, low treatment uptake, and poorer health outcomes, with enhanced risk of infection and increased burden on the h ....Reducing health disparities for culturally and linguistically diverse peoples. This project aims to develop a greater understanding of migrants and the factors that predict poor health outcomes related to blood-borne viruses and sexually transmitted infections. The delayed access by migrants to healthcare from culturally and linguistically diverse backgrounds results in late diagnosis, low treatment uptake, and poorer health outcomes, with enhanced risk of infection and increased burden on the health system. The data collected in this project will assist in developing health services to meet these needs.Read moreRead less
The Political and Economic Agency of Africans in Australia. This project examines the nature and impact of political and economic agency among African migrants in Australia, using mixed methods (survey, interviews, media and policy analysis). With the right policy settings, African migrants and Australian communities stand to benefit enormously from projected African population growth. However, due to a two decade research focus on African refugees, little is known about the successful navigatio ....The Political and Economic Agency of Africans in Australia. This project examines the nature and impact of political and economic agency among African migrants in Australia, using mixed methods (survey, interviews, media and policy analysis). With the right policy settings, African migrants and Australian communities stand to benefit enormously from projected African population growth. However, due to a two decade research focus on African refugees, little is known about the successful navigation of political and economic life among the wider African diaspora. This project will generate new knowledge offering a blueprint for such policy settings. Outcomes include a monograph, 8 papers, and evidence-based policy advice on enhancing African migrant political and economic engagement in Australia. Read moreRead less
Trans/national activism: Organizing for Domestic Worker Rights in Southeast Asia. This project will contribute to the identified national priority, Safeguarding Australia, by providing a better understanding of the issues surrounding labour migration, including the capacity of NGOs and state governments to address the needs and rights of labour migrants in Southeast Asia. By expanding our understanding of the possibilities for democratisation within the region and contributing to theoretical dev ....Trans/national activism: Organizing for Domestic Worker Rights in Southeast Asia. This project will contribute to the identified national priority, Safeguarding Australia, by providing a better understanding of the issues surrounding labour migration, including the capacity of NGOs and state governments to address the needs and rights of labour migrants in Southeast Asia. By expanding our understanding of the possibilities for democratisation within the region and contributing to theoretical developments on the relationship between state and civil society, this research will also contribute to the national interest in influencing institutional reform and democratic transition in Asia. Read moreRead less
Comparative Border Studies. While borders are of increasing interest to Australian scholars and policy-makers, much existing research in Australia is focused on issues of border security or border integrity. There is an urgent need to supplement this work with theoretical and empirical insights drawn from the field of border studies. North America is a key site for international research in this field. Collaboration with North American scholars is thus an important step in developing and expandi ....Comparative Border Studies. While borders are of increasing interest to Australian scholars and policy-makers, much existing research in Australia is focused on issues of border security or border integrity. There is an urgent need to supplement this work with theoretical and empirical insights drawn from the field of border studies. North America is a key site for international research in this field. Collaboration with North American scholars is thus an important step in developing and expanding Australian expertise in border studies. This project will provide the intellectual environment and collaborative networks necessary to establish the first dedicated Centre for Border Studies in Australia.Read moreRead less