Axon Degeneration And Axon Protection In CNS Disease And Injury
Funder
National Health and Medical Research Council
Funding Amount
$389,120.00
Summary
One of the major reasons for the clinical symptoms of neurological diseases such as Alzheimer’s disease and Motor Neuron Disease is the loss of connections between the nerve cells. Nerve cells are connected by specialized processes called axons. In disease these processes can breakdown. This project specifically looks at how axons break down in disease and tests therapeutic strategies to protect them.
The Role Of Excitotoxicity In Mediating Distal Axonal Degneration In ALS
Funder
National Health and Medical Research Council
Funding Amount
$392,952.00
Summary
Amyotrophic lateral sclerosis (ALS), the major cause of motor neuron disease, is a devastating diseasse for which there is no cure. There have been significant advances in understanding the pathology of ALS yet we still don’t know what causes the dying back of spinal motor neurons. We have new evidence that suggests that ALS may, in part, be caused by excitotoxcity - or over stimulation - of neurons in the spinal cord. We will follow this lead using a range of cutting edge experimental models.
Cornstalks and new chums: crime and nutritional status in settler Australia. The project will use records for 200,000 Australian-born and migrant prisoners released from Tasmanian and Victorian gaols between 1853 and 1924 to probe links between childhood well-being and the propensity to re-offend. It will explore the extent to which childhood nutrition (inferred from adult height), the timing and place of birth, and adult occupation can explain migration advantages, the impact of large cities li ....Cornstalks and new chums: crime and nutritional status in settler Australia. The project will use records for 200,000 Australian-born and migrant prisoners released from Tasmanian and Victorian gaols between 1853 and 1924 to probe links between childhood well-being and the propensity to re-offend. It will explore the extent to which childhood nutrition (inferred from adult height), the timing and place of birth, and adult occupation can explain migration advantages, the impact of large cities like Melbourne on child health, and the circumstances that gave rise to recidivism? This project will also explore changes in the composition of offenders over time and the extent to which different penal systems helped offenders to ‘go straight’.Read moreRead less
Integrating teachers’ knowledge and affect to improve mathematics teaching and raise attainment. Mathematics teachers need to know their subject and how to teach it and need passion for the discipline and for inspiring their students to love it. They must believe that their students can learn mathematics and set high academic expectations for all of them. Knowledge and beliefs must be addressed in order to improve teaching, but exactly how can this be done? This project aims to build on existin ....Integrating teachers’ knowledge and affect to improve mathematics teaching and raise attainment. Mathematics teachers need to know their subject and how to teach it and need passion for the discipline and for inspiring their students to love it. They must believe that their students can learn mathematics and set high academic expectations for all of them. Knowledge and beliefs must be addressed in order to improve teaching, but exactly how can this be done? This project aims to build on existing work to develop theoretical insights that will lead to innovative approaches towards teacher change based on the integration of teacher knowledge and affect.Read moreRead less
Demographic consequences of Asian disasters: family dynamics, social capital and migration patterns. This study of the long term demographic consequences of Asian disasters will contribute to development of more effective governmental policies on disaster mitigation, preparedness and reconstruction/recovery, thus assisting to reduce the human and material losses from natural disasters.
Youth Gangs: The Australian Experience. Little systematic research has been undertaken in Australia into the nature and activities of youth gangs. The aim of this project is to provide a national study of youth group formations, processes of group transformation (toward or away from gangs), and strategies the might be employed to curtail gang formation and gang-related behaviour. The study will involve interviews with young people in each capital city, and focus group discussions with youth serv ....Youth Gangs: The Australian Experience. Little systematic research has been undertaken in Australia into the nature and activities of youth gangs. The aim of this project is to provide a national study of youth group formations, processes of group transformation (toward or away from gangs), and strategies the might be employed to curtail gang formation and gang-related behaviour. The study will involve interviews with young people in each capital city, and focus group discussions with youth service providers in each city. The research methods draw upon the instruments presently being developed by the Eurogang Research Network in order to facilitate cross-national comparisons. It will be the first national study of its kind, and will provide new conceptual insights into the character of youth group formation in Australia, baseline youth gang data, and analysis of possible intervention strategies.
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Improving regional secondary students' learning and well-being. Given the academic under-performance and lower life opportunities of Australian regional and rural students compared to their metropolitan counterparts, this research has the potential to make a significant social, cultural and economic contribution to the community. This research will be useful in developing an evidence-based framework to guide policy and practice in implementing an effective systematic approach to regional educati ....Improving regional secondary students' learning and well-being. Given the academic under-performance and lower life opportunities of Australian regional and rural students compared to their metropolitan counterparts, this research has the potential to make a significant social, cultural and economic contribution to the community. This research will be useful in developing an evidence-based framework to guide policy and practice in implementing an effective systematic approach to regional education and, where appropriate, other contexts. The research's economic benefit centres on gains for individuals, local communities, and the nation in enhancing regional students' academic achievements, sense of well-being and aspirations; leading to more productive citizens.Read moreRead less
Building futures for young Australians at risk: a coordinated measurement framework and data archive. This project will build a national data base of evidence about and for programs that address the needs of the 16 per cent of young Australians currently at risk of school non-completion. It will generate important knowledge for program improvement and sustainability and coordination of evidence across diverse and fragmented programs.
Student retention beyond the compulsory schooling years in rural, regional and disadvantaged communities. This project will incorporate longitudinal mixed-methods study to investigate the factors that influence student retention in schooling beyond the compulsory years in rural, regional and disadvantaged communities. Research outcomes will identify best-practice educational strategies to enhance retention in such communities across Australia.
Powerful knowledge: mapping out standards of teachers' knowledge for teaching mathematics and English to achieve the goals of the curriculum. Setting standards is an important step to raising teacher quality. This project will establish benchmarks for teachers' knowledge at all levels of schooling in two key areas of the curriculum: English and mathematics.