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Discovery Early Career Researcher Award - Grant ID: DE240100449
Funder
Australian Research Council
Funding Amount
$426,600.00
Summary
Diversity Oriented Clicking - Streamlined Synthesis of Molecular Frameworks. Innovation in synthetic chemistry drives the discovery of new life-changing drugs, agrochemicals and functional materials. This project aims to use a novel chemical concept, termed Diversity Oriented Clicking, for new sustainable and streamlined synthetic transformations. The new chemical processes are expected to deliver improved economy, efficiency and precision in the synthesis of bioactive molecules and functional m ....Diversity Oriented Clicking - Streamlined Synthesis of Molecular Frameworks. Innovation in synthetic chemistry drives the discovery of new life-changing drugs, agrochemicals and functional materials. This project aims to use a novel chemical concept, termed Diversity Oriented Clicking, for new sustainable and streamlined synthetic transformations. The new chemical processes are expected to deliver improved economy, efficiency and precision in the synthesis of bioactive molecules and functional materials that are inaccessible or challenging to prepare with existing technologies. The conceptual and practical outcomes of this project are expected to benefit both academia and industry as the synthetic routes to diverse complex molecules can be greatly streamlined, and reducing chemical waste and required purification.Read moreRead less
Mid-Career Industry Fellowships - Grant ID: IM230100154
Funder
Australian Research Council
Funding Amount
$1,049,904.00
Summary
Fungi Power: Designer Fungal Cell Factories for Advanced Biomanufacturing. This project aims to build an advanced biomanufacturing platform based on filamentous fungi in collaboration with industry. Using synthetic biology, the project expects to engineer superior fungal host strains customisable to the needs of the industry and to address their technological gaps. The expected outcomes include the development of cost-efficient and sustainable fungal-based bioprocesses for the companies to produ ....Fungi Power: Designer Fungal Cell Factories for Advanced Biomanufacturing. This project aims to build an advanced biomanufacturing platform based on filamentous fungi in collaboration with industry. Using synthetic biology, the project expects to engineer superior fungal host strains customisable to the needs of the industry and to address their technological gaps. The expected outcomes include the development of cost-efficient and sustainable fungal-based bioprocesses for the companies to produce products, such as fine chemicals, pharmaceutical actives and food ingredients. The project would provide significant benefits by enabling existing and emerging companies' commercial successes and competitiveness in global markets, creating new jobs and resulting in the growth of the bio-economy in Australia.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE240100502
Funder
Australian Research Council
Funding Amount
$424,875.00
Summary
Building Molecular Complexity Through Enzyme-Enabled Synthesis. Many valuable natural molecules are too complex to be commercially synthesised by current technologies. Despite advances in synthetic chemistry there is great need to adopt the elegant biocatalytic strategies for complex molecule synthesis found in nature, employing sophisticated enzyme catalysts. This interdisciplinary research program aims to address the shortcomings of traditional synthetic methods through the development of enzy ....Building Molecular Complexity Through Enzyme-Enabled Synthesis. Many valuable natural molecules are too complex to be commercially synthesised by current technologies. Despite advances in synthetic chemistry there is great need to adopt the elegant biocatalytic strategies for complex molecule synthesis found in nature, employing sophisticated enzyme catalysts. This interdisciplinary research program aims to address the shortcomings of traditional synthetic methods through the development of enzyme catalysts to rapidly generate complex molecular structures. These novel molecules can be readily converted into pharmaceuticals and agrochemicals leading to advancements in the bio-enabled production and application of organic molecules in these vital fields. Read moreRead less
Polarity inversion of conjugate acceptors: New opportunities in catalysis. Conjugate acceptors are common chemicals that are readily available from petrochemical and biomass feedstocks. While they are used extensively to build functional materials, including polymers and medicines, the reactions that they can engage in are largely limited to those exploiting their natural reactivity. In this project, catalysis will be used to allow these ubiquitous building blocks to react in entirely new ways. ....Polarity inversion of conjugate acceptors: New opportunities in catalysis. Conjugate acceptors are common chemicals that are readily available from petrochemical and biomass feedstocks. While they are used extensively to build functional materials, including polymers and medicines, the reactions that they can engage in are largely limited to those exploiting their natural reactivity. In this project, catalysis will be used to allow these ubiquitous building blocks to react in entirely new ways. In doing so new chemical reactions will be discovered that convert simple building blocks into sophisticated fine chemicals. The potential utility of the products is diverse and will enable future applications in fields focused on the preparation of functional materials. Read moreRead less
Extending the frontiers of organocatalysis: new reactions involving nucleophilic carbenes. High technology solutions to the problems of today and tomorrow require new materials designed for specific activities. This project will deliver new technologies for the rapid and efficient assembly of materials designed for function.
Challenges to organocatalysis. This project aims to use organocatalysis to generate organocatalytic C=C insertion, C-H functionalisation and carbonyl ylide/1,3-dipolar cycloaddition reactions. Organocatalysis has transformed the way chemical synthesis is performed. However, in the early years the focus of this discipline has primarily been enolate type chemistry, and more challenging reactions, such as those involving carbenoid intermediates, have not been contemplated. Previously such reactions ....Challenges to organocatalysis. This project aims to use organocatalysis to generate organocatalytic C=C insertion, C-H functionalisation and carbonyl ylide/1,3-dipolar cycloaddition reactions. Organocatalysis has transformed the way chemical synthesis is performed. However, in the early years the focus of this discipline has primarily been enolate type chemistry, and more challenging reactions, such as those involving carbenoid intermediates, have not been contemplated. Previously such reactions have only been achieved using transition metal catalysts. This project addresses this limitation, allowing the strengths of organocatalysis (abundance and diversity, access to enantiopurity, elemental sustainability) to affect the broader landscape of catalysis. This approach could present an opportunity to examine reactivity patterns, stereoselectivity and cascade design and may lead to new reaction technologies.Read moreRead less
Lessons From Nature: Late Stage Oxidation in Total Synthesis. This project aims to achieve the chemical synthesis of a number of biologically active novel natural products. The key aspect is the application of chemistry inspired by Nature to deliver molecular complexity in a rapid fashion which would allow for the production of molecules otherwise unavailable in sufficient quantities from the natural sources. This research will utilize late stage oxidation of intermediates to provide ready acces ....Lessons From Nature: Late Stage Oxidation in Total Synthesis. This project aims to achieve the chemical synthesis of a number of biologically active novel natural products. The key aspect is the application of chemistry inspired by Nature to deliver molecular complexity in a rapid fashion which would allow for the production of molecules otherwise unavailable in sufficient quantities from the natural sources. This research will utilize late stage oxidation of intermediates to provide ready access to complex molecules. The main goal is the development of new chemical and biological catalysts for further application in organic synthesis with a view to the production of new medicinal agents and important materials.Read moreRead less
New Reaction Cascades Exploiting N-Heterocyclic Carbenes. Catalytic reactions can enhance the efficiency of chemical synthesis, decreasing environmental and financial cost. This project will undertake the discovery and development of reactions in which a catalyst enables a "production line" of events to provide complex and valuable products. These reactions will proceed with high shape selectivity (enantioselectivity). In addition to new chemical transformations the output of these studies inclu ....New Reaction Cascades Exploiting N-Heterocyclic Carbenes. Catalytic reactions can enhance the efficiency of chemical synthesis, decreasing environmental and financial cost. This project will undertake the discovery and development of reactions in which a catalyst enables a "production line" of events to provide complex and valuable products. These reactions will proceed with high shape selectivity (enantioselectivity). In addition to new chemical transformations the output of these studies includes intellectual capital and human resources, all of which are integral to sustaining a strong chemical manufacturing sector.Read moreRead less
Ring-Strain Relief: Applications in Total Synthesis. This proposal aims to investigate the chemical synthesis of a number of structurally different natural product target molecules by strategies involving the use of either three or four membered ring-strained compounds to afford key synthetic intermediates in an efficient manner. The key aim of this research is to provide more efficient routes to complex natural products and analogues. The research strives to be at the forefront of modern synthe ....Ring-Strain Relief: Applications in Total Synthesis. This proposal aims to investigate the chemical synthesis of a number of structurally different natural product target molecules by strategies involving the use of either three or four membered ring-strained compounds to afford key synthetic intermediates in an efficient manner. The key aim of this research is to provide more efficient routes to complex natural products and analogues. The research strives to be at the forefront of modern synthetic organic chemistry and aims to contribute to the Science of complex molecule synthesis.Read moreRead less