Theory for global biodiversity conservation. Australia's biological diversity underpins much of our economic wealth - for example the remarkable diversity of coral reefs fuels a multibillion dollar tourism industry. We will devise methods to make better decisions about where to invest conservation dollars amongst the biodiversity "hotspots" of the world and Australia to deliver environmental sustainability. We will solve the problem of how much of any environmental budget should be spent on mo ....Theory for global biodiversity conservation. Australia's biological diversity underpins much of our economic wealth - for example the remarkable diversity of coral reefs fuels a multibillion dollar tourism industry. We will devise methods to make better decisions about where to invest conservation dollars amongst the biodiversity "hotspots" of the world and Australia to deliver environmental sustainability. We will solve the problem of how much of any environmental budget should be spent on monitoring conservation actions to make better and more cost-effective decisions. We will create new theory and freely available tools for building systems of marine reserves that allow for threats like coral bleaching and hurricanes.Read moreRead less
Cellular Plasticity in the Brain: discovering molecular mechanisms controlling the production of neurons during brain development, function, ageing and disease. The program aims to understand the mechanisms regulating Brain Plasticity - this recently discovered property of the brain to respond to environmental stimuli, both physiological and pathological, by producing new functional neurons. Specifically, the program will discover how the brain's stem cells are stimulated to produce new neurons. ....Cellular Plasticity in the Brain: discovering molecular mechanisms controlling the production of neurons during brain development, function, ageing and disease. The program aims to understand the mechanisms regulating Brain Plasticity - this recently discovered property of the brain to respond to environmental stimuli, both physiological and pathological, by producing new functional neurons. Specifically, the program will discover how the brain's stem cells are stimulated to produce new neurons. This understanding will significantly expand our knowledge of how the brain develops, and how functions, like memory, are modulated by neuronal replacement. Discoveries will underpin the development of, in association with Australia's biotechnology sector, a new generation of therapeutics, which treat neurological diseases, like Stroke, by stimulating the production of functional neurons.Read moreRead less
Sustainable reform of the Murray-Darling system: Property rights, uncertainty and institutions. The project will develop tools for the modelling of uncertainty in the absence of probabilities and with imperfect knowledge about possible events. It will also formalise and assess the precautionary principle for the sustainable management of complex systems. Finally, the project will apply these tools to analyse and improve policies for the reform of property rights, institutions and land and water ....Sustainable reform of the Murray-Darling system: Property rights, uncertainty and institutions. The project will develop tools for the modelling of uncertainty in the absence of probabilities and with imperfect knowledge about possible events. It will also formalise and assess the precautionary principle for the sustainable management of complex systems. Finally, the project will apply these tools to analyse and improve policies for the reform of property rights, institutions and land and water management in the Murray?Darling system. The project will assist in the formulation of sustainable responses to problems of drought and irrigation related salinity in the Murray?Darling system.Read moreRead less
Engineering Nanostructured Bio-inspired Products. New nanostructured products that draw on biology promise to revolutionise our lives and economy. Designer emulsions and self-assembling particles inspired by viruses are two such products that form the focus for this research programme. The constitutive behaviour of bio-molecular films that control emulsion performance will be characterised and linked to molecular properties and manufacturing conditions. A broad-based technology platform for t ....Engineering Nanostructured Bio-inspired Products. New nanostructured products that draw on biology promise to revolutionise our lives and economy. Designer emulsions and self-assembling particles inspired by viruses are two such products that form the focus for this research programme. The constitutive behaviour of bio-molecular films that control emulsion performance will be characterised and linked to molecular properties and manufacturing conditions. A broad-based technology platform for the in vitro creation of self-assembling biological nanoparticles will also be developed. Key outcomes will be valuable IPR and fundamental engineering science knowledge to ensure that the value chain for this class of products can deliver commercial outcomes.Read moreRead less
New approaches to functional and structural genomics. Genome sequencing has revealed complete sets of macromolecules that make up our cells. We now need to learn how these macromolecules work together in a coordinated fashion. The proposed research will lead to the discovery of new biological molecules, interactions and processes essential for the function of cells, identify new therapeutic targets and strategies to combat disease, identify new concepts in bio- and nanotechnology, and train new ....New approaches to functional and structural genomics. Genome sequencing has revealed complete sets of macromolecules that make up our cells. We now need to learn how these macromolecules work together in a coordinated fashion. The proposed research will lead to the discovery of new biological molecules, interactions and processes essential for the function of cells, identify new therapeutic targets and strategies to combat disease, identify new concepts in bio- and nanotechnology, and train new interdisciplinary researchers. It will underpin the National Research Priorities (Frontier Technologies for Building and Transforming Australian Industries, and Promoting and Maintaining Good Health) and help Australia capitalise on a plethora of opportunities for future economic and health benefits.Read moreRead less