An Investigation Of The Involvement Of Clotting Factors In Abdominal Aortic Aneurysm (AAA) Progression Within A Mouse Model
Funder
National Health and Medical Research Council
Funding Amount
$189,401.00
Summary
Early stage weakening of the main abdominal artery is present in ~100,000 Australians and currently has no accepted therapy. Development of drug therapies which limit progression of the weakening process is urgently needed. In this study involvement of the clotting cascade in artery weakening will be investigated. The study have been planned in order to identify new strategies which can be developed as treatments for artery weakening in patients.
National Centre Of Research Excellence To Improve Management Of Peripheral Arterial Disease
Funder
National Health and Medical Research Council
Funding Amount
$2,618,637.00
Summary
Approximately 15% of adults have blockages or weakness of major arteries in the periphery, associated with impaired quality of life and a high mortality. Significant management deficiencies for these problems include limited diagnostic, prognostic and treatment options, as well as poor adoption of evidence based practice. The proposed national centre will bring together a group of experts in the field to instigate a number of initiatives to improve patient management.
Hazards, Tipping Points, Adaptation and Collapse in the Indo-Pacific World. The project aims to provide a new understanding of Indo-Pacific history post-1000 based on an improved understanding of the interrelationship between natural environmental cycles and events, and social and political cycles and events. By employing specialists and methodologies in both the social and natural sciences, the project aims to identify tipping points or thresholds beyond which both social and natural systems ch ....Hazards, Tipping Points, Adaptation and Collapse in the Indo-Pacific World. The project aims to provide a new understanding of Indo-Pacific history post-1000 based on an improved understanding of the interrelationship between natural environmental cycles and events, and social and political cycles and events. By employing specialists and methodologies in both the social and natural sciences, the project aims to identify tipping points or thresholds beyond which both social and natural systems change irrevocably. The anticipated outcome of the project highlights the importance of natural hazards as potential catalysts of historical change. Current societies might learn from these experiences to better understand disaster risk reduction in the context of anticipated climate variability.Read moreRead less
Understanding Australia in The Age of Humans: Localising the Anthropocene. The project aims to undertake a comprehensive investigation of Australia as a distinctive locality within the global idea of the new epoch of humanity known as the Anthropocene. It aims to analyse and narrate how human interventions have come to transform Australian environments in fundamental and enduring ways, showing the history, impact and implications of human-influenced biophysical planetary change within our distin ....Understanding Australia in The Age of Humans: Localising the Anthropocene. The project aims to undertake a comprehensive investigation of Australia as a distinctive locality within the global idea of the new epoch of humanity known as the Anthropocene. It aims to analyse and narrate how human interventions have come to transform Australian environments in fundamental and enduring ways, showing the history, impact and implications of human-influenced biophysical planetary change within our distinctive and vulnerable continental and ocean environments. It also plans to use both print and museum environments to develop new understandings of the cultural dimensions of the ‘Age of Humans’.Read moreRead less
Talking fish: researching oral history and local knowledge in building community participation in Murray-Darling Basin river rehabilitation. Collecting oral histories of fishing in the Murray-Darling Basin reflects an appreciation of the environmental knowledge of local communities who are on-the-spot custodians of the rivers. Researching everyday fishing will enhance community engagement for river rehabilitation activities, and contribute to international scholarship on inland rivers.
Descartes' Ontology of Everyday Life. Australia has a strong international reputation in philosophy and the history of philosophy. This project will contribute to our standing in the international community of scholars and to the teaching of Australian students in the historical origins of contemporary ideas and problems. It will furthermore contribute to the growing recognition of early modern interdisciplinary studies within Australia by drawing on ideas from the history of science, early mode ....Descartes' Ontology of Everyday Life. Australia has a strong international reputation in philosophy and the history of philosophy. This project will contribute to our standing in the international community of scholars and to the teaching of Australian students in the historical origins of contemporary ideas and problems. It will furthermore contribute to the growing recognition of early modern interdisciplinary studies within Australia by drawing on ideas from the history of science, early modern philosophy, medieval philosophy and the history of early modern thought and ideas.Read moreRead less
The rise of empiricism and the attempt to produce a unified understanding of the world, 1680-1750. Empiricism is often regarded as the characterising feature of modern scientific method, and, in those approaches to psychology and the social and economic sciences that seek to model themselves on successful scientific practice in the physical and life sciences, it often acts as a model of good practice. The project examines the original form of empiricism and shows how it was able to directly enga ....The rise of empiricism and the attempt to produce a unified understanding of the world, 1680-1750. Empiricism is often regarded as the characterising feature of modern scientific method, and, in those approaches to psychology and the social and economic sciences that seek to model themselves on successful scientific practice in the physical and life sciences, it often acts as a model of good practice. The project examines the original form of empiricism and shows how it was able to directly engage questions of value in a novel and revealing way, and how its connection with 'hard' sciences was not merely to provide a methodological gloss on these, but went to the core of what scientific explanation consisted in.Read moreRead less
John Locke, botany and natural kinds. This project will enhance the status of research into early modern science and philosophy in Australia. It is a project of major significance in Locke studies and in the history of botany and it will impinge on a number of current philosophical debates to which Australians are already making a major contribution: the nature of biological species; natural kinds; and scientific method. Those who work on early modern thought in Australia will also benefit from ....John Locke, botany and natural kinds. This project will enhance the status of research into early modern science and philosophy in Australia. It is a project of major significance in Locke studies and in the history of botany and it will impinge on a number of current philosophical debates to which Australians are already making a major contribution: the nature of biological species; natural kinds; and scientific method. Those who work on early modern thought in Australia will also benefit from the close relationship that will be established between the University of Sydney and Oxford University. The publications issuing from the project will be of international significance.Read moreRead less
A Cultural History of Information: Lessons from the Enlightenment. The significance of this project is that it places the idea of 'information explosion' in historical perspective. In early modern Europe (circa 1600-1800) there were already anxieties about 'the multitude of books', the expansion of the sciences, and threats to the ideal of a rounded education. The attempted solutions, such as the use of commonplace books, journals, encyclopaedias and library catalogues, emerged as responses duri ....A Cultural History of Information: Lessons from the Enlightenment. The significance of this project is that it places the idea of 'information explosion' in historical perspective. In early modern Europe (circa 1600-1800) there were already anxieties about 'the multitude of books', the expansion of the sciences, and threats to the ideal of a rounded education. The attempted solutions, such as the use of commonplace books, journals, encyclopaedias and library catalogues, emerged as responses during the Enlightenment, and subsequently became part of our current system of information management. Outcomes will include a scholarly book and another which links earlier problems and responses to current debates.Read moreRead less
Science and the Shaping of Modernity, 1690-1755. It is important that we understand the values underlying our culture, and one form of such understanding is historical. The idea that science provides the standards for all forms of cognitive enquiry is an intrinsic part of modern culture, and the notions of impartiality and objectivity that it is taken to express are closely tied in with estimations of the value of our culture. The history of how this conception emerged in the early-modern period ....Science and the Shaping of Modernity, 1690-1755. It is important that we understand the values underlying our culture, and one form of such understanding is historical. The idea that science provides the standards for all forms of cognitive enquiry is an intrinsic part of modern culture, and the notions of impartiality and objectivity that it is taken to express are closely tied in with estimations of the value of our culture. The history of how this conception emerged in the early-modern period shows that there was nothing self-evident in the assimilation of cognitive values to scientific ones, however, or in the extrapolation of these to general cultural and political values. Read moreRead less