Initial Interactions Of Herpes Simplex Virus With Innate Immune Cells In Human Skin
Funder
National Health and Medical Research Council
Funding Amount
$522,589.00
Summary
Herpes simplex viruses 1 and 2 cause widespread and occasionally serious diseases including genital herpes, neonatal death and encephalitis. Current vaccine candidates are at best partially effective. This grant will examine the way that the virus enters, initially spreads within the skin and interacts with immune cells to help determine which cells should be stimulated by vaccines.
The Management To Optimise Diabetes And MEtabolic Syndrome Risk Reduction Via Nurse-led Intervention (MODERN) Study
Funder
National Health and Medical Research Council
Funding Amount
$1,445,861.00
Summary
There is increasing recognition of society’s responsibility to provide effective and sustainable health care to the entire population and not just selected parts. This practical study will test the impact of a nurse-led, multidisciplinary prevention program to reduce the risk of future cardiovascular events in middle-aged individuals at a high risk of developing cardiovascular disease (CVD) living in regional Australia.
Resolve: A New Treatment - Sensorimotor Retaining With Explaining Pain - For Chronic Low Back Pain.
Funder
National Health and Medical Research Council
Funding Amount
$1,005,534.00
Summary
Most treatments for low back pain that are provided by a GP, physiotherapist or chiropractor are only moderately effective. A new approach is needed. We have developed a new treatment, sensorimotor retraining, based on principles from neuroscience, education, psychology and physiotherapy that we are testing in a randomized controlled trial. If successful this new treatment will provide relief for the millions of Australians who suffer from this debilitating condition.
Improving Oesophageal Adenocarcinoma Outcomes Through Understanding Genomics And Treatment Toxicity.
Funder
National Health and Medical Research Council
Funding Amount
$1,013,282.00
Summary
Oesophageal adenocarcinoma is an aggressive cancer, as most patients will not survive for more than 5 years. Therefore we need to find better ways to treat patients. In this study we will identify the DNA mutations in oesophageal cancers that were part of clinical trial. The data allow us to determine why some tumours responded well to therapy, and why some patients had serious side effects to the treatment. The results will help inform on selection of therapy for future patients.
Physiotherapist Led Stress Inoculation Intervention Integrated With Exercise For Acute Whiplash Injury
Funder
National Health and Medical Research Council
Funding Amount
$518,960.00
Summary
Physical and mental health outcomes following whiplash injury due to a road traffic crash are poor. Early stress system responses are associated with poor recovery. This study will investigate the effectiveness of a physiotherapist led stress inoculation intervention integrated with currently recommended exercise rehabilitation to improve health outcomes after whiplash injury.
Footwear For Self-managing Knee Osteoarthritis Symptoms: The Footstep Trial
Funder
National Health and Medical Research Council
Funding Amount
$590,532.00
Summary
Self-management of symptoms is an important part of treatment for people with knee osteoarthritis. Footwear influences forces across the knee joint and it is unclear which types of shoes are best to minimise arthritis symptoms. This study will compare the effects of flat flexible shoes to stable supportive shoe styles on pain and physical function over 6 months in people with painful knee osteoarthritis.
Can One Health Strategies Be More Effectively Implemented Through Prior Identification Of Public Values?
Funder
National Health and Medical Research Council
Funding Amount
$585,331.00
Summary
Emerging infectious diseases (EIDs) are a significant risk to our region. One Health approaches to EIDs emphasize connections between human,animal and ecological health, enhancing capacity for disease prediction and intervention. This project will examine existing EID legislation,identify social and ethical barriers to effective EID risk governance and create a comprehensive statement of values to ensure the acceptability of One Health approaches to EID control to the Australian community.
Refining And Testing A Promising New Treatment For Chronic Pain.
Funder
National Health and Medical Research Council
Funding Amount
$743,947.00
Summary
Chronic pain costs Australia about 35 billion dollars a year. Recent scientific discoveries show that treatment aimed at correcting problems in how the brain processes sensory input can reduce pain and disability. This project will clarify some key aspects of these problems and use that information to make final adjustments to an already very promising treatment. We will then test the treatment in a definitive and comprehensive clinical trial.
Improving Quality Of Life In High-risk Cancer Populations: A Randomised Trial Of A Structured Intervention For Head And Neck Cancer Survivors
Funder
National Health and Medical Research Council
Funding Amount
$493,220.00
Summary
Patients treated for head and neck cancer commonly experience pain, disfigurement, eating difficulties, depression and fatigue, undermining confidence and quality of life. This study aims to help patients self-manage their ongoing health problems following completion of treatment. This will be achieved through a randomised trial in which patients will be assisted by a trained oncology nurse to develop a tailored survivorship care plan focusing on the patient’s specific medical and emotional conc ....Patients treated for head and neck cancer commonly experience pain, disfigurement, eating difficulties, depression and fatigue, undermining confidence and quality of life. This study aims to help patients self-manage their ongoing health problems following completion of treatment. This will be achieved through a randomised trial in which patients will be assisted by a trained oncology nurse to develop a tailored survivorship care plan focusing on the patient’s specific medical and emotional concerns.Read moreRead less
A Randomised Controlled Trial Of Enhanced Parenting Capacity To Improve Developmental Outcomes In Preterm Infants
Funder
National Health and Medical Research Council
Funding Amount
$1,045,141.00
Summary
In Australia there are 2, 600 very preterm survivors each year. 50% will have education/behavioural difficulties and 10% major disability. We aim to optimise the development of infants born very preterm through a tailored Positive Parenting Program. We predict reductions in child behavioural and emotional problems at 2 years corrected age.