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Discovery Early Career Researcher Award - Grant ID: DE130100689
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Applying nature's chemistry to the synthesis of complex bioactive natural products. Organic molecules come in all shapes and sizes, and the synthesis of them is crucial to industries as diverse as pharmaceuticals, electronics, cosmetics and agrochemicals. This project aims to develop new ways of making unusual and potentially useful naturally occurring organic molecules using chemistry that mimics how they are formed in nature.
Discovery Early Career Researcher Award - Grant ID: DE120102113
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Total synthesis inspired by nature. This project aims to improve and develop the way in which we make organic substances; our medicines, agrochemicals, and designed materials. This will be achieved through biomimetics; which harnesses the power of evolution by mimicking how nature synthesises organic compounds.
Discovery Early Career Researcher Award - Grant ID: DE180100462
Funder
Australian Research Council
Funding Amount
$364,975.00
Summary
Molecular complexity through multi-bond forming reactions. This project aims to develop techniques for the synthesis of many, highly valuable natural and designed molecules which are too complex to be synthesised on scale with current methodologies. The project aims to develop new strategies for the simultaneous construction of several chemical bonds, with a focus on molecular scaffolds that can be readily converted into pharmaceuticals, potential drug candidates, chiral ligands, and agrochemica ....Molecular complexity through multi-bond forming reactions. This project aims to develop techniques for the synthesis of many, highly valuable natural and designed molecules which are too complex to be synthesised on scale with current methodologies. The project aims to develop new strategies for the simultaneous construction of several chemical bonds, with a focus on molecular scaffolds that can be readily converted into pharmaceuticals, potential drug candidates, chiral ligands, and agrochemicals. This will ultimately lead to advancements in both the production and application of organic molecules in these fields.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE130101350
Funder
Australian Research Council
Funding Amount
$373,038.00
Summary
A synthetic biology approach for mining the secondary metabolomes of fungal phytopathogens. Synthetic biology approaches will be employed to identify the secondary metabolites produced by the two important wheat pathogens, Stagonospora nodorum and Mycosphaerella graminicola. This will lead to the discovery of novel chemicals and facilitate our understanding of the roles of secondary metabolites in wheat diseases.
Discovery Early Career Researcher Award - Grant ID: DE120101653
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Selective fluorination chemistry: a tool for creating bioactive, shape-controlled peptides. Fluorine atoms are desirable substituents in drug candidates because they can increase metabolic stability and hydrophobicity, and because they can be used to constrain molecules into optimal bioactive conformations. These concepts are being exploited to create shape-controlled peptides with applications in anti-cancer and anti-microbial therapy.
Discovery Early Career Researcher Award - Grant ID: DE240100449
Funder
Australian Research Council
Funding Amount
$426,600.00
Summary
Diversity Oriented Clicking - Streamlined Synthesis of Molecular Frameworks. Innovation in synthetic chemistry drives the discovery of new life-changing drugs, agrochemicals and functional materials. This project aims to use a novel chemical concept, termed Diversity Oriented Clicking, for new sustainable and streamlined synthetic transformations. The new chemical processes are expected to deliver improved economy, efficiency and precision in the synthesis of bioactive molecules and functional m ....Diversity Oriented Clicking - Streamlined Synthesis of Molecular Frameworks. Innovation in synthetic chemistry drives the discovery of new life-changing drugs, agrochemicals and functional materials. This project aims to use a novel chemical concept, termed Diversity Oriented Clicking, for new sustainable and streamlined synthetic transformations. The new chemical processes are expected to deliver improved economy, efficiency and precision in the synthesis of bioactive molecules and functional materials that are inaccessible or challenging to prepare with existing technologies. The conceptual and practical outcomes of this project are expected to benefit both academia and industry as the synthetic routes to diverse complex molecules can be greatly streamlined, and reducing chemical waste and required purification.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE170101452
Funder
Australian Research Council
Funding Amount
$360,000.00
Summary
Silk-based conformal pressure sensing devices. This project aims to develop silk biomaterials-based biocompatible and conformal pressure sensing devices and systems for sustainable wearable electronics. Biocompatible conformal sensing interfaces and sensor arrays will be developed for real-time highly sensitive measurement of pressure, critical for accurate and comprehensive health monitoring and electronic skins. It is believed that the wearable products will provide comfort, utility and accura ....Silk-based conformal pressure sensing devices. This project aims to develop silk biomaterials-based biocompatible and conformal pressure sensing devices and systems for sustainable wearable electronics. Biocompatible conformal sensing interfaces and sensor arrays will be developed for real-time highly sensitive measurement of pressure, critical for accurate and comprehensive health monitoring and electronic skins. It is believed that the wearable products will provide comfort, utility and accurate physical information to end users, and improve the performance of personnel working in demanding environments, such as in defence forces, athletics and outfield industrial operations, by continuously monitoring physiological parameters.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE240100502
Funder
Australian Research Council
Funding Amount
$424,875.00
Summary
Building Molecular Complexity Through Enzyme-Enabled Synthesis. Many valuable natural molecules are too complex to be commercially synthesised by current technologies. Despite advances in synthetic chemistry there is great need to adopt the elegant biocatalytic strategies for complex molecule synthesis found in nature, employing sophisticated enzyme catalysts. This interdisciplinary research program aims to address the shortcomings of traditional synthetic methods through the development of enzy ....Building Molecular Complexity Through Enzyme-Enabled Synthesis. Many valuable natural molecules are too complex to be commercially synthesised by current technologies. Despite advances in synthetic chemistry there is great need to adopt the elegant biocatalytic strategies for complex molecule synthesis found in nature, employing sophisticated enzyme catalysts. This interdisciplinary research program aims to address the shortcomings of traditional synthetic methods through the development of enzyme catalysts to rapidly generate complex molecular structures. These novel molecules can be readily converted into pharmaceuticals and agrochemicals leading to advancements in the bio-enabled production and application of organic molecules in these vital fields. Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE150100784
Funder
Australian Research Council
Funding Amount
$373,254.00
Summary
Molecular probe development for the oxytocin and vasopressin receptors. The oxytocin and vasopressin receptors are part of a 600 million year old signalling system that is widely distributed in the kingdom of life. It is involved in many fundamental physiological functions, however we still lack a complete toolbox of selective probes to delineate the individual receptor subtypes. This project aims to introduce a novel and innovative strategy that uses state-of-the art discovery techniques to ide ....Molecular probe development for the oxytocin and vasopressin receptors. The oxytocin and vasopressin receptors are part of a 600 million year old signalling system that is widely distributed in the kingdom of life. It is involved in many fundamental physiological functions, however we still lack a complete toolbox of selective probes to delineate the individual receptor subtypes. This project aims to introduce a novel and innovative strategy that uses state-of-the art discovery techniques to identify selective ligands in nature. Leads will be developed into molecular probes to facilitate in-depth studies of this system. This strategy is applicable to other systems and the outcomes will contribute to a significant advancement of knowledge in chemical biology.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE160101313
Funder
Australian Research Council
Funding Amount
$383,536.00
Summary
New chromatography-electrophysiology methods for semiochemical discovery. The aim of this research is to develop new tools for discovering natural products that mediate insect-insect and plant-insect communication. Knowledge of such semiochemicals is critical for many applications in conservation biology, agriculture, and horticulture. Many of these compounds are difficult to identify with current chemical and electrophysiological methods. The goal is to develop new technology combining state-of ....New chromatography-electrophysiology methods for semiochemical discovery. The aim of this research is to develop new tools for discovering natural products that mediate insect-insect and plant-insect communication. Knowledge of such semiochemicals is critical for many applications in conservation biology, agriculture, and horticulture. Many of these compounds are difficult to identify with current chemical and electrophysiological methods. The goal is to develop new technology combining state-of-the-art chemical separation techniques and electroantennography to enable detection and identification of a broad range of chemicals of biological importance. The intended outcome is to apply this technology to pollination systems of plants of conservation and evolutionary significance, and of commercial importance in terms of insect control and pollination.Read moreRead less