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New Discoveries in Organic Synthesis Inspired by the Efficiency of Nature. Nature can assemble complex organic molecules from simple starting materials with apparent ease, but the laboratory synthesis of these natural products is very difficult. This project aims to mimic the way in which Nature constructs organic compounds and thus develop more efficient, greener synthetic processes in which there is a rapid build up of molecular complexity via “biomimetic” reactions. We will integrate this app ....New Discoveries in Organic Synthesis Inspired by the Efficiency of Nature. Nature can assemble complex organic molecules from simple starting materials with apparent ease, but the laboratory synthesis of these natural products is very difficult. This project aims to mimic the way in which Nature constructs organic compounds and thus develop more efficient, greener synthetic processes in which there is a rapid build up of molecular complexity via “biomimetic” reactions. We will integrate this approach with modern methods of catalysis, including electrochemistry, photochemistry and biocatalysis. As a result, this work will expand the chemical space available to synthetic chemists working in the pharmaceutical industry. A further benefit is the training of the next generation of Australian synthetic chemists. Read moreRead less
Using natural products to inspire discoveries in synthesis and biosynthesis. This project aims to understand the organic chemistry that occurs in the biosynthesis of unusual antibiotic natural products by marine microorganisms. In an interdisciplinary approach, proposed biosynthetic intermediates will be synthesised and screened against newly isolated enzymes from the microorganisms of interest. This will allow the elucidation of biosynthetic pathways, and aid the discovery of new chemoenzymatic ....Using natural products to inspire discoveries in synthesis and biosynthesis. This project aims to understand the organic chemistry that occurs in the biosynthesis of unusual antibiotic natural products by marine microorganisms. In an interdisciplinary approach, proposed biosynthetic intermediates will be synthesised and screened against newly isolated enzymes from the microorganisms of interest. This will allow the elucidation of biosynthetic pathways, and aid the discovery of new chemoenzymatic reactivity that may be broadly useful in organic synthesis. Non-enzymatic, predisposed organic reactions will also be uncovered during the project. The benefit of this project will be an improvement in our ability to synthesise potential antibiotics using a combined synthetic organic and chemoenzymatic approach. This could lead to useful new antibiotics in the future.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE130100689
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Applying nature's chemistry to the synthesis of complex bioactive natural products. Organic molecules come in all shapes and sizes, and the synthesis of them is crucial to industries as diverse as pharmaceuticals, electronics, cosmetics and agrochemicals. This project aims to develop new ways of making unusual and potentially useful naturally occurring organic molecules using chemistry that mimics how they are formed in nature.
Predisposed organic synthesis inspired by the simplicty of nature. The aim of this project is to use the simplicity and efficiency of biosynthesis to inspire the development of new strategies for the synthesis of whole families of related natural products with known antibiotic activity. Natural products with potent antibiotic properties are produced by microorganisms as a means of chemical defence. These complex molecules are biosynthesised from a limited set of simple biosynthetic building bloc ....Predisposed organic synthesis inspired by the simplicty of nature. The aim of this project is to use the simplicity and efficiency of biosynthesis to inspire the development of new strategies for the synthesis of whole families of related natural products with known antibiotic activity. Natural products with potent antibiotic properties are produced by microorganisms as a means of chemical defence. These complex molecules are biosynthesised from a limited set of simple biosynthetic building blocks via predisposed, complexity generating cascade reactions. The project aims to generate new lead compounds for the advancement of next-generation antibiotics. The synthesis of proposed biosynthetic intermediates would also allow enzymatic studies to help confirm the novel biosynthetic proposals.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE180100462
Funder
Australian Research Council
Funding Amount
$364,975.00
Summary
Molecular complexity through multi-bond forming reactions. This project aims to develop techniques for the synthesis of many, highly valuable natural and designed molecules which are too complex to be synthesised on scale with current methodologies. The project aims to develop new strategies for the simultaneous construction of several chemical bonds, with a focus on molecular scaffolds that can be readily converted into pharmaceuticals, potential drug candidates, chiral ligands, and agrochemica ....Molecular complexity through multi-bond forming reactions. This project aims to develop techniques for the synthesis of many, highly valuable natural and designed molecules which are too complex to be synthesised on scale with current methodologies. The project aims to develop new strategies for the simultaneous construction of several chemical bonds, with a focus on molecular scaffolds that can be readily converted into pharmaceuticals, potential drug candidates, chiral ligands, and agrochemicals. This will ultimately lead to advancements in both the production and application of organic molecules in these fields.Read moreRead less
New strategies for the stereoselective synthesis of Stemona alkaloids and the discovery of new bioactive molecules. The project aims to develop innovative methods to prepare bioactive natural products and their analogues with potential applications as new and safer therapeutic drugs and agricultural chemicals. These products would be of benefit to Australians in the future.
Taking nature's lead in the development of new and improved enzyme inhibitors. This project will address some key fundamental issues associated with advancing a chemical entity from proof of principle through to a new pharmaceutical. The compounds in the study target cancer, cataract and other diseases that are confronting Australia's ageing population.