Linkage Infrastructure, Equipment And Facilities - Grant ID: LE130100141
Funder
Australian Research Council
Funding Amount
$310,000.00
Summary
High resolution nuclear magnetic resonance spectroscopy for glycomics, metabonomics and soft materials applications. This project will enhance the nuclear magnetic resonance spectroscopy capabilities and the world class research being undertaken at the Institute for Glycomics, Griffith University and Queensland University of Technology. This powerful technique can contribute information in diverse research areas such as glycomics, metabonomics and soft materials research.
Discovery Early Career Researcher Award - Grant ID: DE180101635
Funder
Australian Research Council
Funding Amount
$343,450.00
Summary
DNA origami functionalised nanoscale surfaces. This project aims to combine the strengths of top-down and bottom-up nanofabrication to build hybrid structures. In traditional top-down nanofabrication, large systems pattern a semiconductor substrate to build up sophisticated devices. In contrast, in the emerging field of bottom-up nanotechnology, clever design of molecular interactions drives the self-assembly of smaller building blocks into more complex structures, with smaller features. This pr ....DNA origami functionalised nanoscale surfaces. This project aims to combine the strengths of top-down and bottom-up nanofabrication to build hybrid structures. In traditional top-down nanofabrication, large systems pattern a semiconductor substrate to build up sophisticated devices. In contrast, in the emerging field of bottom-up nanotechnology, clever design of molecular interactions drives the self-assembly of smaller building blocks into more complex structures, with smaller features. This project aims to bridge the gap between these two technologies to build functional devices. These devices will be applied, for example, to understand biological problems such as why blood clots form on implanted medical devices - their main cause of failure.Read moreRead less
Engineering Bioresponsive Hybrid Nanodevices using RNA, Peptides and Synthetic Polymers. This project aims to develop new microRNA polymer nanoassemblies with enhanced bioresponsive properties. Nanoengineered functional RNA-polymer materials can exploit both the recognition properties of RNA and the responsiveness of the polymer to tailor the structural and physicochemical properties of such systems. Further, targeting ligands (antibody, aptamers) tethered to the RNA-polymer nanoassembly could a ....Engineering Bioresponsive Hybrid Nanodevices using RNA, Peptides and Synthetic Polymers. This project aims to develop new microRNA polymer nanoassemblies with enhanced bioresponsive properties. Nanoengineered functional RNA-polymer materials can exploit both the recognition properties of RNA and the responsiveness of the polymer to tailor the structural and physicochemical properties of such systems. Further, targeting ligands (antibody, aptamers) tethered to the RNA-polymer nanoassembly could augment cellular uptake and delivery. The development of imaging and tracking methodology to accurately measure intracellular miRNA payload and localisation in a 3D tissue mimicking matrix is also planned.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE100100142
Funder
Australian Research Council
Funding Amount
$500,000.00
Summary
An integrated liquid chromatography mass spectrometry nuclear magnetic resonance (LC-MS-NMR) facility for applications in proteomics and organic chemistry. This application completes the requested liquid chromatography mass spectrometry nuclear magnetic resonance (LCMS-NMR) facility and will allow the training of over 150 researchers, significantly enhancing their research productivity and translation of outcomes in areas of national importance. New breakthroughs in drug development, smart mate ....An integrated liquid chromatography mass spectrometry nuclear magnetic resonance (LC-MS-NMR) facility for applications in proteomics and organic chemistry. This application completes the requested liquid chromatography mass spectrometry nuclear magnetic resonance (LCMS-NMR) facility and will allow the training of over 150 researchers, significantly enhancing their research productivity and translation of outcomes in areas of national importance. New breakthroughs in drug development, smart materials, organic electronic materials and biomedical research require routine access to cutting edge technology. The LCMS-NMR augments the capabilities of our research teams at the forefront of these efforts. These include understanding the impact of the environment on plant and animal development, pest animal control, development of new biotechnology tools, new drugs and new methods for the detection of narcotics and explosives.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE100100010
Funder
Australian Research Council
Funding Amount
$720,000.00
Summary
A 5-D Correlative Imaging Platform: Combining the strengths of light and electron microscopy. This will be Australia's first dedicated five-dimensional multiphoton-microscopy platform, allowing observation of dynamic structures across different length and time scales under controlled temperatures, followed by high-resolution electron microscopy studies on the same samples. This platform will provide a unique characterisation tool to Australia's top-flight investigators, and so contribute to the ....A 5-D Correlative Imaging Platform: Combining the strengths of light and electron microscopy. This will be Australia's first dedicated five-dimensional multiphoton-microscopy platform, allowing observation of dynamic structures across different length and time scales under controlled temperatures, followed by high-resolution electron microscopy studies on the same samples. This platform will provide a unique characterisation tool to Australia's top-flight investigators, and so contribute to the nation's research priorities. It will enable: fundamental studies of cancer, neural diseases and immune disorders; the development of frontier technologies, such as smart nanomaterials, biosensors and targeted drug delivery; and applied research to help plants and soils adapt to climate variability, and to increase sustainable use of water.Read moreRead less