A multimodal approach to unravel the role of surface properties in nanoparticle-cell interactions using models of medical emergencies. The design and development of multimodal nanoparticles seek to expand upon the benefits of nanoparticles by delivering imaging and therapeutic agents to specific organs, enabling detection and treatment of disease in a single procedure. The successful implementation of this technology is dependent on our detailed understanding of the nanoparticle-cell interaction ....A multimodal approach to unravel the role of surface properties in nanoparticle-cell interactions using models of medical emergencies. The design and development of multimodal nanoparticles seek to expand upon the benefits of nanoparticles by delivering imaging and therapeutic agents to specific organs, enabling detection and treatment of disease in a single procedure. The successful implementation of this technology is dependent on our detailed understanding of the nanoparticle-cell interactions. This project will address this very important issue by evaluating a range of surface functionalised nanoparticles in highly significant models of medical emergencies. This project will enable development of advanced therapeutic interventions for cancer, central nervous system injuries, cardiovascular diseases and pregnancy related disorders.Read moreRead less
Intelligent nanoparticles: Interactive tools to decode brain activity. This project aims to use nanoparticles and integrated nanoparticle devices to unravel causal relationships between molecular events and high-level brain activity. These devices, capable of real-time sensing and adaptive responses, could expose previously unmeasurable cellular events and establish their physiological effects. This is expected to reveal the complex dynamics in the living brain and advance neuroscience and analy ....Intelligent nanoparticles: Interactive tools to decode brain activity. This project aims to use nanoparticles and integrated nanoparticle devices to unravel causal relationships between molecular events and high-level brain activity. These devices, capable of real-time sensing and adaptive responses, could expose previously unmeasurable cellular events and establish their physiological effects. This is expected to reveal the complex dynamics in the living brain and advance neuroscience and analytical chemistry.Read moreRead less
Harnessing the bioactivity of proteins and polypeptides: understanding and controlling adsorption processes to optimise linker free immobilisation. This project will use physical techniques and simulations to understand the interactions of biomolecules and plasma activated surfaces, allowing control of the biomolecule layer composition, orientation and conformation. This control, together with the ability of these surfaces to "lock-in" the optimised layer, will create a new generation of biodevi ....Harnessing the bioactivity of proteins and polypeptides: understanding and controlling adsorption processes to optimise linker free immobilisation. This project will use physical techniques and simulations to understand the interactions of biomolecules and plasma activated surfaces, allowing control of the biomolecule layer composition, orientation and conformation. This control, together with the ability of these surfaces to "lock-in" the optimised layer, will create a new generation of biodevices.Read moreRead less
Hybrid diamond materials for next generation sensing, biodiagnostic and quantum devices. Nanodiamond mixed with non-diamond materials will revolutionise quantum-photonic devices spawning a step change in nanoscale bio-chemical and remote sensing. The outcomes of this work will have a significant impact on the prognosis of diseases, security, and communications and will enhance Australia's reputation as a world leader in nano-materials.
Engineering layered double hydroxide nanoparticles toward an efficient targeted clinical delivery system. This project will develop a more effective drug delivery system using clay nanoparticles and biofriendly serum proteins. Outcomes from this project will provide a tremendous opportunity for potent therapies of cancers, vasculature and neuronal diseases, and place Australia at the forefront of nanotechnology drug delivery research.
Integrated Nanoplatform for Multiomics Analysis of Cell-to-Cell Interaction. This project aims to develop an integrated nanoplatform for analysis of exosomes produced by host-pathogen interaction at the single cell level. This will be accomplished by engineering an innovative device involving plasmonic nanoparticles to probe exosomes molecular profiles over time. The intended outcome is a generic and robust platform for detailed molecular analysis of the consequences of cell-to-cell interactions ....Integrated Nanoplatform for Multiomics Analysis of Cell-to-Cell Interaction. This project aims to develop an integrated nanoplatform for analysis of exosomes produced by host-pathogen interaction at the single cell level. This will be accomplished by engineering an innovative device involving plasmonic nanoparticles to probe exosomes molecular profiles over time. The intended outcome is a generic and robust platform for detailed molecular analysis of the consequences of cell-to-cell interactions. Single cell scale will greatly improve detection accuracy for heterogeneous cell populations. Benefits will include new knowledge of cell-to-cell communication and intellectual property in manufacturing, which will foster collaborations across institutions and Australian industry by providing new technological solutions.Read moreRead less
Engineering nanoscale tools for cellular interrogation. The aim is to address fundamental hurdles to engineering seamless nanobiointerfaces between electroactive nanoscale tools and living cells. This is expected to allow efficient delivery of many bioactive cargo types into cells, intracellular sampling of cytosol contents, and probing of action potential, all at the cell—material interface. New, powerful, electroactive nanoscale tools that deliver precise spatio-temporal resolution and minimal ....Engineering nanoscale tools for cellular interrogation. The aim is to address fundamental hurdles to engineering seamless nanobiointerfaces between electroactive nanoscale tools and living cells. This is expected to allow efficient delivery of many bioactive cargo types into cells, intracellular sampling of cytosol contents, and probing of action potential, all at the cell—material interface. New, powerful, electroactive nanoscale tools that deliver precise spatio-temporal resolution and minimal invasiveness and perturbation are likely to transform ex-vivo cellular processes. The intended outcomes are crucial for maximising precision in engineering and implementing of ex-vivo cellular processes. Fundamental advances in knowledge may eventually be a platform for developing cell-based therapies.
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Autotransporter assembly: new insights and biotechnological potential. The objective of this project is to improve our understanding of a fundamental biological problem: how autotransporters are assembled into cellular membranes. Autotransporters are a large family of bacterial proteins that play key roles in the pathogenesis of several infectious diseases. Currently, the precise mechanism by which disease-causing molecules are assembled into the outer membranes of bacteria and mitochondria is p ....Autotransporter assembly: new insights and biotechnological potential. The objective of this project is to improve our understanding of a fundamental biological problem: how autotransporters are assembled into cellular membranes. Autotransporters are a large family of bacterial proteins that play key roles in the pathogenesis of several infectious diseases. Currently, the precise mechanism by which disease-causing molecules are assembled into the outer membranes of bacteria and mitochondria is poorly understood. The knowledge that the project develops may inform future strategies aimed at the rational treatment of bacterial and mitochondrial diseases.Read moreRead less
Bridging the interface between nanoengineered materials and biological systems. Advances in nanotechnology have the potential to revolutionise how we treat many diseases. Nanoengineered drug carriers can deliver drugs to the areas in the body where they are required, limiting harmful side effects. This project will investigate how nanomaterials interact with biological systems and understand any potential side effects.
Novel tools and nanotechnology to navigate intracellular trafficking. This project aims to investigate how material accesses different compartments inside cells, also known as trafficking. Using immunology, cell biology and nanotechnology, the project will manipulate intracellular trafficking to achieve specific cellular functions. Outcomes will also form the basis of intellectual property development for new products by Australian biotechnology companies. These products will improve veterinary ....Novel tools and nanotechnology to navigate intracellular trafficking. This project aims to investigate how material accesses different compartments inside cells, also known as trafficking. Using immunology, cell biology and nanotechnology, the project will manipulate intracellular trafficking to achieve specific cellular functions. Outcomes will also form the basis of intellectual property development for new products by Australian biotechnology companies. These products will improve veterinary and human health services, leading to increased productivity.Read moreRead less