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Understanding How Toxins Interact With Lipid Membranes And Ion Channels
Funder
National Health and Medical Research Council
Funding Amount
$598,220.00
Summary
Chronic pain affects one in five Australians and current treatments have limited effectiveness, with only about one third of patients getting meaningful, pain relief. The aim of the current project is to create alternative treatments for pain that can potentially lead to the reduced suffering and improvement of life quality of many Australians. To achieve this aim we propose to study how spider toxins interact with cells and deactivate sensor targets responsible for chronic pain.
Understanding How Perforin Forms Pores: The Role Of Calcium And Lipids.
Funder
National Health and Medical Research Council
Funding Amount
$797,813.00
Summary
This grant aims to study perforin, a key part of the mammalian immune system. The work will facilitate the development of perforin inhibitors. It is anticipated that these data will be of utility in developing first in class drugs to improve the success of bone marrow transplantation.
Burkholderia Pseudomallei Disulfide-forming Proteins: Structure, Function And Inhibition
Funder
National Health and Medical Research Council
Funding Amount
$707,032.00
Summary
Our research will lead to a better understanding of melioidosis, a disease endemic to Northern Australia and which impacts indigenous communities at twice the rate of the rest of the population. This project will also aim to generate new compounds with the potential for development as treatments against this devastating disease.