STABILISING G PROTEIN-COUPLED RECEPTORS FOR DRUG DISCOVERY
Funder
National Health and Medical Research Council
Funding Amount
$628,140.00
Summary
Prescription drugs targeting human proteins called GPCRs are sold as effective treatments for many diseases. However, there are over 800 different types of GPCRs in the human body and only a small fraction is targeted by drugs, mainly because GPCRs are unstable and thus difficult to work with in the laboratory. We are applying newly developed technologies to engineer stabilised ?1-adrenoceptors, a class of GPCRs, for drug discovery against cardiovascular diseases, epilepsy and neurodegeneration
Novel Approaches To Understanding Peptide G-protein-coupled Receptor Activation
Funder
National Health and Medical Research Council
Funding Amount
$665,043.00
Summary
G protein-coupled receptors (GPCRs) are proteins that exist on every human cell, where they sense, and respond to environmental stimuli. Because of their importance they are targeted by drugs to treat many diseases. However little is known about the molecular steps that underlie cellular responses upon drug binding and this has hindered new drug development. This project uses new technology to determine the complex pathway of GPCR activation upon drug binding which will aid new drug development.
Unravelling The Binding And Activation Mechanism Of A Complex G Protein-coupled Receptor
Funder
National Health and Medical Research Council
Funding Amount
$1,041,638.00
Summary
The peptide hormone relaxin is currently in a Phase III trial for the treatment of heart failure. However the peptide is not a good drug as it can't be taken orally and is very expensive to produce. We will study the interaction of relaxin with its cell surface receptor and the mechanisms by which the receptor functions. The knowledge gained will aid in the design of smaller, more potent and orally active forms of relaxin for the treatment of heart failure
Resolving And Targeting The Complex Molecular Mechanisms Underlying GPCR Signalling
Funder
National Health and Medical Research Council
Funding Amount
$1,071,370.00
Summary
Receptors are located on the surface of all human cells to allow our cells to respond to their environment. Over 30% of prescription drugs act through particular receptors called GPCRs, however effective drugs without side effects are difficult to develop because we do not have a deep understanding of how GPCRs transmit complex signals. In this proposal we seek to resolve the atomic-level details of GPCR signalling to assist in the development of better drugs for a diverse range of diseases.
Superfluidity in strongly correlated ultra-cold atomic Fermi gases. Ultra-cold atoms are one of the most rapidly developing areas in twenty-first century physics. The scientific importance of studying strongly interacting Fermi gases is indicated by the fact that five Nobel prizes in physics were awarded in fields relevant to ultra-cold atoms in the last decade. Australia is now developing a reputation for world-class research in this new area, with new ultra-cold fermion experiments now underwa ....Superfluidity in strongly correlated ultra-cold atomic Fermi gases. Ultra-cold atoms are one of the most rapidly developing areas in twenty-first century physics. The scientific importance of studying strongly interacting Fermi gases is indicated by the fact that five Nobel prizes in physics were awarded in fields relevant to ultra-cold atoms in the last decade. Australia is now developing a reputation for world-class research in this new area, with new ultra-cold fermion experiments now underway in Melbourne. This project will build national and international cooperation in this field, provide world-class research training opportunities and advance Australia's leadership position. As well as improving scientific understanding, it has the potential to lead to new energy-saving technologies in the future.Read moreRead less
Ultracold atomic Fermi gases in the strongly interacting regime: A new frontier of quantum many-body physics. Ultra-cold atoms are one of the most rapidly developing areas in twenty-first century physics. The scientific importance of studying strongly interacting Fermi gases is indicated by the fact that five Nobel prizes in physics have been awarded in fields relevant to ultra-cold atoms in the last decade. Australia is now developing a reputation for world-class research in this new area, with ....Ultracold atomic Fermi gases in the strongly interacting regime: A new frontier of quantum many-body physics. Ultra-cold atoms are one of the most rapidly developing areas in twenty-first century physics. The scientific importance of studying strongly interacting Fermi gases is indicated by the fact that five Nobel prizes in physics have been awarded in fields relevant to ultra-cold atoms in the last decade. Australia is now developing a reputation for world-class research in this new area, with new cold-fermion experiments now underway in Melbourne. This project will build national and international cooperation in this field, provide world-class research training opportunities and advance Australia's leadership position. As well as improving scientific understanding, it has the potential to lead to new energy-saving technologies in future.Read moreRead less
Imbalanced superfluidity: The quantum mystery that defies solution. The project focuses on ground-breaking research in ultra-cold atomic Fermi gases, the fastest developing area in twenty-first century physics. Australia has already invested heavily in ultra-cold atomic Bose gases including atom lasers. An experimental program on atomic Fermi gases has also been initiated in the ARC Centre of Excellence for Quantum-Atom Optics (ACQAO). Our project, if successful, will help elevate Australia to a ....Imbalanced superfluidity: The quantum mystery that defies solution. The project focuses on ground-breaking research in ultra-cold atomic Fermi gases, the fastest developing area in twenty-first century physics. Australia has already invested heavily in ultra-cold atomic Bose gases including atom lasers. An experimental program on atomic Fermi gases has also been initiated in the ARC Centre of Excellence for Quantum-Atom Optics (ACQAO). Our project, if successful, will help elevate Australia to a major international research centre in cold Fermi gases, complementing its ongoing strength developed through the ACQAO experiments, and will bring fundamental knowledge that could have a significant and profound influence upon future technologies: for example, novel electronics, lossless power transmission and magnetic levitation.Read moreRead less
Quantum magnetometry on the microscale. This proposal will create a microscope for magnetic fields by measuring the quantum spin of a Bose-Einstein condensate at temperatures near absolute zero. Classical measurements of spin have underpinned transforming technologies, from magnetic resonance imaging to terabyte-scale hard-disc storage. We will make a truly quantum measurement of spin which will create a magnetic field microscope one million times more sensitive than the current state-of-the-art ....Quantum magnetometry on the microscale. This proposal will create a microscope for magnetic fields by measuring the quantum spin of a Bose-Einstein condensate at temperatures near absolute zero. Classical measurements of spin have underpinned transforming technologies, from magnetic resonance imaging to terabyte-scale hard-disc storage. We will make a truly quantum measurement of spin which will create a magnetic field microscope one million times more sensitive than the current state-of-the-art. The magnetic field microscope will be sensitive enough to measure fields from single biological cells and from superconducting nanosurfaces, giving critical new perspectives in biomedical research and next-generation electronics.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0560959
Funder
Australian Research Council
Funding Amount
$165,000.00
Summary
The Macquarie National Low Temperature Optoelectronic Thin Film Growth Facility. Funding is requested for an Australian facility for the growth of nitride and oxide thin films with in-situ optical analysis equipment for the monitoring of growth parameters. It is envisaged that this facility would be for the development of materials and device structures for photonic, electronic and optoelectronic applications. The facility will also provide a leading Australian source of these materials for fund ....The Macquarie National Low Temperature Optoelectronic Thin Film Growth Facility. Funding is requested for an Australian facility for the growth of nitride and oxide thin films with in-situ optical analysis equipment for the monitoring of growth parameters. It is envisaged that this facility would be for the development of materials and device structures for photonic, electronic and optoelectronic applications. The facility will also provide a leading Australian source of these materials for fundamental material studies utilising nuclear analysis and implantation technologies, high resolution X-ray diffraction, high spatial resolution micro-cathodoluminescence and other forms of analysis. Ex-situ optical analysis equipment is also requested for post-growth evaluation to compliment and evaluate the in-situ analysis.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE210101093
Funder
Australian Research Council
Funding Amount
$439,587.00
Summary
Development and application of super-sensitive spinning quantum sensors. This project aims to use physical rotation of diamonds on timescales faster than quantum decoherence to set new detection limits for precision quantum sensing of electric and magnetic fields. This potentially allows us to see for the first time how the Coriolis force acts on current flowing in a frame rotating 700,000,000 times faster than the earth. The project's expected outcomes are electro-magnetic sensors with unpreced ....Development and application of super-sensitive spinning quantum sensors. This project aims to use physical rotation of diamonds on timescales faster than quantum decoherence to set new detection limits for precision quantum sensing of electric and magnetic fields. This potentially allows us to see for the first time how the Coriolis force acts on current flowing in a frame rotating 700,000,000 times faster than the earth. The project's expected outcomes are electro-magnetic sensors with unprecedented sensitivity that could find application in areas ranging from detecting household wiring to locating magnetic anomalies for defence. These outcomes should fill a blind spot of quantum magnetometry, have commercial impact and expand our knowledge of quantum physics in the rotating frame.Read moreRead less