Optimising the search for the next discovery in particle physics. This project aims to uncover the new theory of particle physics that can simultaneously explain the Higgs mechanism, the presence of dark matter and the current abundance of matter over antimatter in our universe. This is not possible with current theories. This project aims to find viable theories using a wide range of data from particle astrophysics and collider experiments. With the resulting knowledge, this project aims to des ....Optimising the search for the next discovery in particle physics. This project aims to uncover the new theory of particle physics that can simultaneously explain the Higgs mechanism, the presence of dark matter and the current abundance of matter over antimatter in our universe. This is not possible with current theories. This project aims to find viable theories using a wide range of data from particle astrophysics and collider experiments. With the resulting knowledge, this project aims to design, optimise and implement better searches for new physics at the Large Hadron Collider (LHC). The new LHC results will be used to either determine the correct explanation for any new discoveries or alternatively to provide definitive limits on new theories. The results will be used to make high impact statements on the design of future facilities.Read moreRead less
EFR3: Novel gatekeeper of cell proliferation. This interdisciplinary, cross-institutional project uses leading-edge mass spectrometry and the yeast genetic model to enhance knowledge of fundamental signalling mechanisms common to cell proliferation of eukaryotic cells. Building on extensive preliminary data that identifies novel energy-stress control points, this research will generate insights into critical and conserved features of nutrient stress control of cell proliferation that ensures cel ....EFR3: Novel gatekeeper of cell proliferation. This interdisciplinary, cross-institutional project uses leading-edge mass spectrometry and the yeast genetic model to enhance knowledge of fundamental signalling mechanisms common to cell proliferation of eukaryotic cells. Building on extensive preliminary data that identifies novel energy-stress control points, this research will generate insights into critical and conserved features of nutrient stress control of cell proliferation that ensures cell survival. This project advances basic and applied biology. Its outcomes will be relevant to several research areas and industries, specifically to the propagation of cell cultures that nowadays contributes to the production of a myriad of biotechnical and pharmaceutical commodities.
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How do cells survive nutrient stress? Insight into mechanisms. This project studies cell survival under nutrient stress in eukaryotes. Building on extensive preliminary data that identifies novel TOR (Target of Rapamycin) Complex 2 (TORC2) control points it expects to generate new knowledge of critical and conserved features of stress control of macroautophagy that ensures cell survival. It uses interdisciplinary and innovative approaches to validate and characterize nutrient-stress dependent si ....How do cells survive nutrient stress? Insight into mechanisms. This project studies cell survival under nutrient stress in eukaryotes. Building on extensive preliminary data that identifies novel TOR (Target of Rapamycin) Complex 2 (TORC2) control points it expects to generate new knowledge of critical and conserved features of stress control of macroautophagy that ensures cell survival. It uses interdisciplinary and innovative approaches to validate and characterize nutrient-stress dependent signaling. Expected outcomes include novel insights into environmental control of cell proliferation and forging cross institutional collaborations. This knowledge benefits basic and applied biology and is relevant to industries/projects utilizing living cells as nutrient supports cell survival and proliferation.Read moreRead less