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Dual 68-Gallium/FDG PET Imaging In Neuroendocrine Tumours
Funder
National Health and Medical Research Council
Funding Amount
$75,006.00
Summary
Neuroendocrine tumours (NETs) are uncommon cancers. Low-grade tumours may grow very slowly and not require treatment, but high-grade tumours can grow over weeks and have a poor prognosis. Grade is determined by looking at tissue, but this may vary considerably even in different disease sites in the same patient. Two PET scans (FDG PET and 68Gallium PET) can show high grade and low grade disease respectively, and we plan to investigate their combination in imaging advanced neuroendocrine tumours.
Magnetic Resonance Imaging Of Structural And Functional Connectivity In Lesion-negative Temporal Lobe Epilepsy Compared To Hippocampal Sclerosis
Funder
National Health and Medical Research Council
Funding Amount
$99,883.00
Summary
Epileptic seizures in the temporal lobe of the brain can affect how the temporal lobe connects to other brain regions. We are using new MRI techniques to investigate these altered connections, in patients who have no other abnormality on their brain scans. Our aim is to find distinctive patterns of altered connectivity, which will help us better understand this type of epilepsy.
The Distribution And Spread Of Motor System Dysfunction In Early Motor Neurone Disease.
Funder
National Health and Medical Research Council
Funding Amount
$107,287.00
Summary
At present, motor neurone disease remains an incurable, fatal neurodegenerative condition with few disease-modifying treatments. There is ongoing uncertainty around the mechanisms of onset and disease propagation. This research aims to clarify the onset and pathophysiological mechanisms of motor neurone disease using novel neurophysiological and neuroimaging techniques, the results of which will contribute to the search for early diagnositc markers and new treatments.
Using Diffusion MRI For Understanding The Relationship Between Memory Decline And Corticothalamic Tracts
Funder
National Health and Medical Research Council
Funding Amount
$57,578.00
Summary
Stroke populations are at a risk of dementia. Structural changes have been demonstrated to precede cognitive changes, providing a potential for early diagnosis and intervention. Magnetic resonance imaging markers of structural connectivity are powerful predictors of dementia. As a longitudinal study, this proposal has the unique advantage that I will be able to detect changes in post-stroke brain networks in the 3 years after stroke. This raises the potential for future clinical application.
Novel Cardiac Imaging Modalities And Biomarkers In Acute Decompensated Heart Failure.
Funder
National Health and Medical Research Council
Funding Amount
$100,926.00
Summary
Heart failure (an inability of the heart to meet the bodyÍs metabolic requirements) is a major public health burden with high rates of death, hospitalisation, and reduced quality of life. Further research is required to investigate the underlying mechanisms. This project will analyse abnormalities in heart structure and function using new techniques in heart ultrasound and magnetic resonance imaging, and blood tests. Findings in this study may help to guide the development of future therapies to ....Heart failure (an inability of the heart to meet the bodyÍs metabolic requirements) is a major public health burden with high rates of death, hospitalisation, and reduced quality of life. Further research is required to investigate the underlying mechanisms. This project will analyse abnormalities in heart structure and function using new techniques in heart ultrasound and magnetic resonance imaging, and blood tests. Findings in this study may help to guide the development of future therapies to improve outcomes in patients with heart failure.Read moreRead less
Stroke is a major cause of death and disability in adult across the world. Understanding how exactly brain cells are affected in stroke and how they are injured, and how they response to treatment is important in order to develop new treatment to maximize recovery and minimize brain injury after stroke. This project uses advanced MRI being performed at several time points after a stroke to study how the brain tissues recovers or dies after a stroke.
Overcoming Radiation Resistance In Glioblastoma With Novel Metabolic Modulations
Funder
National Health and Medical Research Council
Funding Amount
$62,554.00
Summary
Aim 1 is to document the pathological, surgical, radiotherapy and chemotherapy patterns of care in the Australian setting using the AGOG (Australian Genomics and Clinical Outcomes of Glioma) database. The second aim to develop non-invasive imaging biomarkers which can be used to monitor treatment efficacy. The third aim is to improve outcomes using drug and radiation combination therapy. in the treatment of high grade gliomas.
The Investigation Of Markers Of Relapse And Potential Therapeutic Targets In Methamphetamine Dependence Using Novel Techniques
Funder
National Health and Medical Research Council
Funding Amount
$103,088.00
Summary
This project focuses on methamphetamine dependence. It will investigate some of the major harms associated with methamphetamine use and will seek to identify who is more likely to develop these harms. This research will use a range of novel measures and techniques to investigate biological, psychological, cognitive and social risk factors for methamphetamine-related harms. This study will contribute to a better understanding of methamphetamine dependence, and potential targets for treatment.
Altered Sense Of Identity In Dementia: Cognitive And Neurobiological Underpinnings
Funder
National Health and Medical Research Council
Funding Amount
$108,902.00
Summary
People with dementia commonly experience changes in their sense of identity, causing significant distress for the individual and their families. This project will investigate these changes comprehensively, determining their contributing factors and how they relate to dementia’s effect on the brain. Outcomes from this project will improve understanding of the experience of the person with dementia, informing personalised care and enhancing the quality of patient-carer relationships.
Ischaemic Stroke And Atrial Fibrillation: Development Of A Novel Artificial Intelligence System Using Magnetic Resonance Imaging
Funder
National Health and Medical Research Council
Funding Amount
$92,335.00
Summary
Atrial fibrillation (AF) is an abnormal heart rhythm which is a common cause of stroke. AF can often go unrecognized as patients may have no symptoms. This project aims to develop computer software which can automatically detect underlying AF based on MRI brain scan pattern, in patients who have had an acute stroke. This project has the potential to offer several benefits, including reduced need for costly investigations, improved AF detection and a larger pool of patients being treated for AF.