Nanoparticle-based Anti-VEGF Treatment For Ocular Neovascularization
Funder
National Health and Medical Research Council
Funding Amount
$576,921.00
Summary
Diseases like AMD and DR are the leading cause for substantial and irreversible vision loss as a direct effect of pathologic ocular neovascularization and have a significant economic impact on individuals, families, health systems and countries. Nowadays, the treatment requires frequent intravitreal injections of anti-VEGF antibody with all the risks of an invasive intraocular procedure. Nanotechonoly-based drug delivery system will provide a less invasive treatment for this kind of disease.
Prevention Of HIV-1 Infection By Adeno Associated Virus Vector-delivered Broadly Neutralizing Antibodies Or Antibody-like Molecules
Funder
National Health and Medical Research Council
Funding Amount
$875,854.00
Summary
A promising neutralizing molecule has boosted hopes of an HIV vaccine. It remains unknown how well this molecule prevents HIV infection under conditions reflecting “real world” exposure, including exposure to HIV in the form of cells carrying virus or free-floating virus in the presence of semen. We will assess this molecule for their ability to inhibit transmission of HIV-like viruses under these conditions. These experiments will define requirements to protect against HIV infection.
A Role For The Pulvinar Nucleus In Visual Cortical Development And Plasticity
Funder
National Health and Medical Research Council
Funding Amount
$844,435.00
Summary
This project will investigate a part of the brain responsible for processing visual information, the pulvinar. This area has received little attention but has more recently been associated with the capacity for infants to recover vision following injuries such as stroke, as well as in mental health conditions such as schizophrenia. We will take a cell-to-system approach to uncover how this area develops and modulates the processing of visual information.
Rapid Plasticity In Sensory Systems - Linking Neuronal Adaptation And Perception
Funder
National Health and Medical Research Council
Funding Amount
$650,810.00
Summary
The activity of individual sensory neurons in the brain is surprisingly variable and continuously changing. It is unclear how reliable perception of the world can be generated from the activity of “noisy” neurons, and it remains unclear why neuronal sensitivity should change in the first place! This project will give insights into how groups of sensory neurons collectively overcome their intrinsic variability to support reliable visual perception.