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When Prometheus Needs A Hand – How Human Amnion Epithelial Cells Resolve Fibrosis And Regenerate The Liver
Funder
National Health and Medical Research Council
Funding Amount
$530,653.00
Summary
Cirrhosis can progress to end stage disease for which transplantation provides the only hope for survival. Liver donors in Australia are scarce; the need for donor organs is increasing. Using stem cells to repair and regenerate damaged liver may provide an alternative to organ transplantation. We are studying placental stem cells that can decrease inflammation and increase progenitor cells to repair and regenerate liver. Our goal is to use these stem cells as treatment for human liver disease
Cellular Cross-talk Between Liver Progenitor Cells And Hepatic Stellate Cells Is Required For Hepatic Fibrogenesis
Funder
National Health and Medical Research Council
Funding Amount
$618,517.00
Summary
Deloitte Access Economics data proposes the total economic burden of liver disease in Australia in 2012 was >$50 billion. This study will identify how the liver heals itself by inducing liver cell populations which interact to regenerate damaged liver tissue in chronic liver disease. This knowledge may lead to the development of novel therapeutic interventions for the treatment of liver scarring and liver cancer, and to assist in normal liver regeneration following chronic liver disease.
Role Of Hepatic Stellate Cell And Liver Progenitor Cell Interactions In The Regulation Of Wound Healing And Liver Regeneration
Funder
National Health and Medical Research Council
Funding Amount
$620,716.00
Summary
The liver has a remarkable capacity for regeneration following acute and chronic liver injury, however, the mechanisms which facilitate this wound healing are not understood. This project will examine the interactions between different liver cell populations, including hepatic stellate cells (liver fibroblasts) and liver progenitor cells (stem cells of the liver) and will determine which factors regulate inflammation, liver scarring and restitution of liver mass following chronic liver injury.
Smart utilisation of cobaltite based electrodes on solid oxide fuel cells. This project aims to develop solid oxide fuel cell technologies with significantly simplified fabrication steps and at low cost. It aims to generate fundamental knowledge on the polarisation induced electrode/electrolyte interfaces under fuel cell operation conditions. The advanced fuel cell technologies will in turn substantially increase the energy conversion efficiency and provide significant benefit in the reduction o ....Smart utilisation of cobaltite based electrodes on solid oxide fuel cells. This project aims to develop solid oxide fuel cell technologies with significantly simplified fabrication steps and at low cost. It aims to generate fundamental knowledge on the polarisation induced electrode/electrolyte interfaces under fuel cell operation conditions. The advanced fuel cell technologies will in turn substantially increase the energy conversion efficiency and provide significant benefit in the reduction of greenhouse emission.Read moreRead less
Highly efficient electric power and value-added synthesis gas co-generation from methane with zero greenhouse gas emission. This project addresses a novel sealing-free solid oxide fuel cell system producing simultaneously synthesis gas and electricity from methane with zero greenhouse gas emission. The project aims to deliver economic benefits and contribute to environmental protection and increased employment opportunities.
Highly ordered and tuneable mesostructured perfluorosulfonic acid polymers as novel proton exchange membranes for fuel cells. The purpose of the project is to develop an innovative perfluorofonic acid based proton exchange membranes (PEM) with ordered and tuneable mesopores and it is expected that PEM fuel cell power systems based on such new PEMs will have significant impact on the advancement of fuel cell technologies and the reduction in greenhouse gas emission.
Understanding And Applying Macrophage-mediated Effects On Liver Progenitor Cells To Treat Liver Disease.
Funder
National Health and Medical Research Council
Funding Amount
$628,109.00
Summary
As liver cancer risk correlates with increased liver stem/progenitor cell numbers, therapies that reduce their numbers will reduce cancer development. On the contrary, therapies to increase progenitor cell numbers will assist their use in cell therapy-based approaches or artificial liver devices to treat chronic liver disease. This project will determine how to use inflammatory cells to manipulate progenitor cell numbers.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE120100026
Funder
Australian Research Council
Funding Amount
$480,000.00
Summary
A surface characterisation facility. This surface characterisation facility will provide scientists with an understanding of material's surfaces and interfaces. This will lead to a range of new technologies and innovative solutions required to address the many resource and environmental challenges facing our planet now and in the future.
New mesoporous materials for use in high temperature proton exchange fuel cell membranes. A novel high temperature proton exchange membrane based on heteropolyacid (HPA) functionalised mesoporous silica will be developed. This research into the fundamental materials science of novel proton exchange membranes is expected to impact significantly on the advancement and commercialisation of portable fuel cell devices.
Leveraging Genomics Strategies To Generate Adult Neurons From IPSCs And Somatic Cells
Funder
National Health and Medical Research Council
Funding Amount
$1,593,336.00
Summary
Recent advances have made it possible to derive myriad specialized human cells from stem cells or by directly reprogramming cell identity. However, these derived cells are generally arrested at a fetal developmental stage, and do not mature to function like adult cells. We will use new genomic, epigenetic, cell reprogramming, and manipulation methods to discover how to derive mature cells, aiming to generate mature neurons for use in neurobiology research, disease modeling, and drug screening.