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Methylation Sensitive Genes And The Transition To Allergic Disease: A Twin Study
Funder
National Health and Medical Research Council
Funding Amount
$493,843.00
Summary
Australia has amongst the highest reported prevalence allergic conditions (including asthma) in the world. Despite this, little is known about how these conditions arise. Mounting evidence implicates environmentally induced disruption of the genetic blueprint via a process known as epigenetics. We are combining the strengths of a unique collection of identical twins where one of a pair is sensitive to house dust mite, with cutting edge genomics, to characterise the pathways leading to allergy in ....Australia has amongst the highest reported prevalence allergic conditions (including asthma) in the world. Despite this, little is known about how these conditions arise. Mounting evidence implicates environmentally induced disruption of the genetic blueprint via a process known as epigenetics. We are combining the strengths of a unique collection of identical twins where one of a pair is sensitive to house dust mite, with cutting edge genomics, to characterise the pathways leading to allergy in children.Read moreRead less
The development of inexpensive negatively charged films to increase the efficiency of commercial solar cells. This project aims to reduce the cost of solar electricity by developing inexpensive, negatively charged dielectric films. When deposited on the surfaces of commercial solar cells, these films will significantly increase cell efficiency, thereby producing more power from a given area.
Uncovering The Basis Of Inflammatory And Immunodeficiency Diseases
Funder
National Health and Medical Research Council
Funding Amount
$15,718,075.00
Summary
A world-class team from 3 institutions, spanning disciplines of clinical and experimental immunology, therapeutics, signalling and genetics, will identify how immune and inflammatory responses are controlled in both health and disease. The major outcomes of this work will be the generation of new knowledge, concepts and approaches to diagnose, prevent and treat the major human health problems of autoimmune diseases, inflammation, allergy and immunodeficiency.
Transparent metal oxides, a window of opportunity for silicon solar cells. This project aims to develop novel silicon heterojunction solar cells based on transparent conductive metal oxides (TCOs). Thin layers of zinc, gallium and molybdenum oxides present negligible absorption losses, which leads to a high output current. The project will optimise them as surface passivating layers, to achieve a high output voltage. TCOs can also provide good lateral conductivity, to boost the fill factor. The ....Transparent metal oxides, a window of opportunity for silicon solar cells. This project aims to develop novel silicon heterojunction solar cells based on transparent conductive metal oxides (TCOs). Thin layers of zinc, gallium and molybdenum oxides present negligible absorption losses, which leads to a high output current. The project will optimise them as surface passivating layers, to achieve a high output voltage. TCOs can also provide good lateral conductivity, to boost the fill factor. The research proposes to create insight into the physical mechanisms of selective contacts for electrons and holes, paving the way for a range of innovative solar cell concepts. Transparent metal oxides open new windows of opportunity to increase the conversion efficiency of silicon solar cells using simpler fabrication processes.Read moreRead less
It is feasible to sequence patient genomes but we need to know more about how genetic variants cause complex disease. We have sequenced genomes from patients with immune deficiency and will test the idea that genetic variation causes consistent changes in particular white blood cells, thus providing a bridge between genomic information and clinical diagnosis. Outcomes will include more accurate diagnosis, better understanding of immunity, and a strategy for using whole genome information.
Investigating B Cell Development, Maintenance And High-affinity Antibody Production By ENU Mutagenesis
Funder
National Health and Medical Research Council
Funding Amount
$408,388.00
Summary
B cells are essential for the protection against infections. This application aims to identify new genes that are crucial for the development or function of B cells and will investigate how mutations in newly discovered genes contribute to defects in the development and function of B cells and the pathogenesis of B cell leukaemia.
Dynamic Trafficking Of Amino Acid Transporters At Synapses And Their Role In Regulating Neurotransmission
Funder
National Health and Medical Research Council
Funding Amount
$421,219.00
Summary
Brain cells release chemical neurotransmitters to activate their neighbours. The most abundant neurotransmitter is glutamate, which mediates most of the communication in the brain. Following release, this neurotransmitter must be rapidly recycled to prevent levels being depleted and neurotransmission failing. The subject of this grant is to understand what molecules and pathways are used to recycle glutamate in the brain, and how its supply is controlled to sustain continual brain activation.
Alpha-particles linked to recombinant antibodies targeting tumour cells have potential to effectively treat tumours while minimising normal tissue side effects. We will explore a novel alpha-particle therapy approach to solid tumours, by delivering 225Ac directly into tumour cells, or into cells that support the tumour (microenvironment). This approach will hopefully result in development of a new approach to treatment of cancers that are resistant to conventional therapies.
Efficient PV-Thermal Micro-concentrator. Australia must reduce its dependence on carbon sources for electricity, heating, and cooling. The PV-thermal hybrid micro-concentrator development will deliver a light-weight, low-profile, cost-effective system that can be installed in almost any situation, with versatile output that can deliver electricity at grid parity as well as providing water heating, space heating, industrial process heat, and solar cooling capabilities. The nation will benefit thr ....Efficient PV-Thermal Micro-concentrator. Australia must reduce its dependence on carbon sources for electricity, heating, and cooling. The PV-thermal hybrid micro-concentrator development will deliver a light-weight, low-profile, cost-effective system that can be installed in almost any situation, with versatile output that can deliver electricity at grid parity as well as providing water heating, space heating, industrial process heat, and solar cooling capabilities. The nation will benefit through enhanced energy independence, international research recognition, and reduced greenhouse gas emissions. Further, successful commercialisation of this technology will enhance Australia's research standing and provide a good royalty income that will fund future research and development.Read moreRead less
Methylation-sensitive T Cell Genes And Childhood Food Allergy.
Funder
National Health and Medical Research Council
Funding Amount
$461,232.00
Summary
Australia has the highest reported prevalence food allergy in the world. Despite this, little is known about how allergy develops. Mounting evidence implicates environmentally induced disruption of the genetic blueprint via a process known as epigenetics. We are combining the strengths of food challenge proven food allergy with assessment of immune functioning & cutting edge genomics, to extensively characterise the pathways leading to food allergy in children.