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Kruppel-like factors and the methylome. This project aims to test the hypothesis that the KLF/SP family of transcription factors work in part via dynamic interactions with methylated cytosine nucleotides in DNA. This is fundamental to their function as pioneer factors in reprograming and their ability to co-ordinate differentiation and organogenesis. Conversely, dynamic changes in methylation status engage or disengage new regulatory elements in the genome via recruitment of KLF/SP family protei ....Kruppel-like factors and the methylome. This project aims to test the hypothesis that the KLF/SP family of transcription factors work in part via dynamic interactions with methylated cytosine nucleotides in DNA. This is fundamental to their function as pioneer factors in reprograming and their ability to co-ordinate differentiation and organogenesis. Conversely, dynamic changes in methylation status engage or disengage new regulatory elements in the genome via recruitment of KLF/SP family proteins as specific effectors. This project will address a new paradigm in genetics that is likely to underpin development.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE210100125
Funder
Australian Research Council
Funding Amount
$837,000.00
Summary
National Facility for Infrared Technologies. This project aims to establish a national facility for infrared (IR) technologies. The facility will include advanced imaging and spectroscopy facilities as well as unique tools for wafer-scale mapping of IR materials and devices. Combined, the facility will enable new diagnostic capabilities of supersonic combustion processes, aid establishment of wavelength agile integrated photonic chips and provide non-destructive quantitative electro-optical char ....National Facility for Infrared Technologies. This project aims to establish a national facility for infrared (IR) technologies. The facility will include advanced imaging and spectroscopy facilities as well as unique tools for wafer-scale mapping of IR materials and devices. Combined, the facility will enable new diagnostic capabilities of supersonic combustion processes, aid establishment of wavelength agile integrated photonic chips and provide non-destructive quantitative electro-optical characterisation of IR materials and devices. Establishment of these state-of-the-art capabilities across Australia will have clear benefits in fundamental sciences such as astronomy and quantum information as well as key industry branches in defence, aerospace, communications and security.Read moreRead less
Special Research Initiatives - Grant ID: SR1101002
Funder
Australian Research Council
Funding Amount
$21,000,000.00
Summary
Stem Cells Australia. Despite progress in stem cell research, scientists do not understand how stem cells “decide” what to become. Stem Cells Australia will draw upon strengths within Australia’s premier stem cell research universities and institutes. This collaboration between leading bioengineering, nanotechnology, stem cell and advanced molecular analysis experts, will fast-track efforts to deliver a fundamental understanding of the mechanisms of stem cell regulation and differentiation, and ....Stem Cells Australia. Despite progress in stem cell research, scientists do not understand how stem cells “decide” what to become. Stem Cells Australia will draw upon strengths within Australia’s premier stem cell research universities and institutes. This collaboration between leading bioengineering, nanotechnology, stem cell and advanced molecular analysis experts, will fast-track efforts to deliver a fundamental understanding of the mechanisms of stem cell regulation and differentiation, and the ability to control and influence this process. Stem Cells Australia will deliver new methods for stem cell propagation and manipulation, new translational technologies for therapeutic applications, and will prepare Australia’s future stem cell scientific leaders.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE110100159
Funder
Australian Research Council
Funding Amount
$360,000.00
Summary
National facility for biased target deposition of alloyed nanolayers. This facility will enhance Australia's strengths and capabilities in fabricating structures, with applications in multiple research fields including opto-magneto-electronics, next generation lithium ion batteries and energy nanogenerators. It will enhance Australia's research profile as a leader in nanotechnology.