Vesicular Trafficking Pathways Underpinning Neuronal Secretion And Survival
Funder
National Health and Medical Research Council
Funding Amount
$697,209.00
Summary
Plethora of diseases of the nervous system are caused by defects in vesicular trafficking including neurodegenerative diseases such as Alzheimer’s disease. I will explore the mechanisms underpinning synaptic vesicular trafficking using novel super resolution techniques and reveal the how secretory vesicles traffic to the plasma membrane, undergo exocytosis, and recycle. I will also explain how in the crowded environment of the presynaptic terminals, retrograde cargoes are transported back to the ....Plethora of diseases of the nervous system are caused by defects in vesicular trafficking including neurodegenerative diseases such as Alzheimer’s disease. I will explore the mechanisms underpinning synaptic vesicular trafficking using novel super resolution techniques and reveal the how secretory vesicles traffic to the plasma membrane, undergo exocytosis, and recycle. I will also explain how in the crowded environment of the presynaptic terminals, retrograde cargoes are transported back to the cell body thereby carrying survival signals.Read moreRead less
Neuromuscular Junction Toxicity After Anticholinesterase Pesticide Poisoning And Envenomation.
Funder
National Health and Medical Research Council
Funding Amount
$1,351,392.00
Summary
The study builds on strong existing NHMRC funded collaborative research links between Sri Lanka and Australia in research which have reduced mortality and provided better evidence for treatment of pesticide poisoning. We will study the paralysing effects of acute insecticide poisoning and snakebite on the human nervous system. We aim to determine whether these can be predicted early in the course of the illness and the long term effects. We also aim to see if any particular insecticides cause mo ....The study builds on strong existing NHMRC funded collaborative research links between Sri Lanka and Australia in research which have reduced mortality and provided better evidence for treatment of pesticide poisoning. We will study the paralysing effects of acute insecticide poisoning and snakebite on the human nervous system. We aim to determine whether these can be predicted early in the course of the illness and the long term effects. We also aim to see if any particular insecticides cause more problems than others.Read moreRead less