Computational Modeling of RNA Control Networks. One of the most exciting new ideas for understanding the regulation of gene expression involves the contribution of intronic and other non-protein coding RNAs to regulatory networks within cells. This novel role for intronic RNA is currently making headlines within the molecular biology community but has not yet been modelled computationally. The network of genetic regulatory interactions forms a complex system which is amenable to computational ....Computational Modeling of RNA Control Networks. One of the most exciting new ideas for understanding the regulation of gene expression involves the contribution of intronic and other non-protein coding RNAs to regulatory networks within cells. This novel role for intronic RNA is currently making headlines within the molecular biology community but has not yet been modelled computationally. The network of genetic regulatory interactions forms a complex system which is amenable to computational analysis. This project aims to extend current models to incorporate intronic RNA feedback control, complementing parallel studies in vivo, and computationally testing ideas essential to the theoretical understanding of the basis of life.Read moreRead less
A new theory for retinotectal map formation. How brains become wired up during development is a question of
importance to both biology and computing. In this project we adopt a
novel computational approach to understanding the development of
topographic maps, a wiring pattern that is ubiquitous in biological
nervous systems. This project will build capacity for research in
computational neuroscience in Australia. It may also lead to
technological benefits such as new ideas for the design o ....A new theory for retinotectal map formation. How brains become wired up during development is a question of
importance to both biology and computing. In this project we adopt a
novel computational approach to understanding the development of
topographic maps, a wiring pattern that is ubiquitous in biological
nervous systems. This project will build capacity for research in
computational neuroscience in Australia. It may also lead to
technological benefits such as new ideas for the design of self-wiring
computing devices, and new insights into
the causes of wiring defects both during normal development and
rewiring after injury.
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Wiring up the nervous system: how do axons detect molecular gradients? This project will improve our understanding of how the nervous system
becomes wired up during development. This will ultimately allow better
therapies for some types of developmental disorders, and for repairing
damaged connections for instance in the spinal cord. The theoretical
models developed will improve our understanding of the computations
necessary to generate appropriate wiring of the nervous system, which
may ....Wiring up the nervous system: how do axons detect molecular gradients? This project will improve our understanding of how the nervous system
becomes wired up during development. This will ultimately allow better
therapies for some types of developmental disorders, and for repairing
damaged connections for instance in the spinal cord. The theoretical
models developed will improve our understanding of the computations
necessary to generate appropriate wiring of the nervous system, which
may facilitate the development of self-organizing computing
devices. The project will also provide unique research training at the
interface of biology and computation, building capacity for such
interdisciplinary research throughout Australia.
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The genomic programming of complex organisms. The project will have far-reaching consequences in medicine, agriculture, biotechnology, engineering, information science and associated industries. It will provide a platform for the rationalization of genetic epidemiology and genetic improvement programs, the development of a wide range of new diagnostics and therapies, the development of new core technologies and practical approaches in genetics and genetic diversity, a framework for advanced gen ....The genomic programming of complex organisms. The project will have far-reaching consequences in medicine, agriculture, biotechnology, engineering, information science and associated industries. It will provide a platform for the rationalization of genetic epidemiology and genetic improvement programs, the development of a wide range of new diagnostics and therapies, the development of new core technologies and practical approaches in genetics and genetic diversity, a framework for advanced genetic engineering, the development of new principles and systems for information storage and transmission, and the design of artificial systems capable of self-referential assembly in other environments.Read moreRead less
ARC Centre for Complex Systems. The Australian Centre for Complex Systems brings together leading researchers from several disciplines and institutions to conduct research on questions fundamental to understanding and managing complex systems. Its core research program, based on the theme of computation in and by networks of agents, has two interwoven strands. The science strand addresses questions about emergent properties, natural computation, and nonlinear dynamics. The engineering strand add ....ARC Centre for Complex Systems. The Australian Centre for Complex Systems brings together leading researchers from several disciplines and institutions to conduct research on questions fundamental to understanding and managing complex systems. Its core research program, based on the theme of computation in and by networks of agents, has two interwoven strands. The science strand addresses questions about emergent properties, natural computation, and nonlinear dynamics. The engineering strand addresses issues about methodology, modelling toolkits, and management and control. Practical applications are advanced via collaborative projects that address key issues in biology, environment, and socio-economics.Read moreRead less
An Automated Bioimaging System for High-Content Cell-Cycle Screening. 1) Providing a better understanding of the biological complexities
that will advance knowledge in life science research and facilitate the development of new anti-cancer drugs.
2) Supporting Australian academic institutions in a challenging field of innovative research through international, interdisciplinary collaborations, and publications in journals of high quality scientific research.
3) Providing research training ....An Automated Bioimaging System for High-Content Cell-Cycle Screening. 1) Providing a better understanding of the biological complexities
that will advance knowledge in life science research and facilitate the development of new anti-cancer drugs.
2) Supporting Australian academic institutions in a challenging field of innovative research through international, interdisciplinary collaborations, and publications in journals of high quality scientific research.
3) Providing research training in a research venture that requires expertise and collaboration in the disciplines of biology, engineering, computer science, and mathematics.
4) Bringing economic and social benefits for Australia by enhancing important industries and existing technologies in medicine, and biotechnology.
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