Androgen receptor: A master regulator of lipid metabolism. This project aims to understand how male sex hormones, or androgens, affect the amount and metabolism of fats in normal body tissues. By integrating our multi-disciplinary expertise in androgen action, molecular biology, metabolism and bioinformatics with novel techniques and instrumentation, this collaboration expects to generate the first detailed picture of how fat metabolism is controlled by androgens in humans, and how closely this ....Androgen receptor: A master regulator of lipid metabolism. This project aims to understand how male sex hormones, or androgens, affect the amount and metabolism of fats in normal body tissues. By integrating our multi-disciplinary expertise in androgen action, molecular biology, metabolism and bioinformatics with novel techniques and instrumentation, this collaboration expects to generate the first detailed picture of how fat metabolism is controlled by androgens in humans, and how closely this relates to mice. Expected outcomes and benefits will be a new understanding of which aspects of fat metabolism are most influenced by androgens, and an ability to anticipate potential metabolic impacts of natural or pharmacological fluctuations in androgen levels in humans, laboratory animals and livestock.Read moreRead less
Organic Bionics: Soft Materials to Solve Hard Problems in Neuroengineering. This project aims to combine innovations in organic conductors, nanotechnology, 3D biofabrication and neuroengineering to develop a bioelectronic system capable of wireless neuromodulation with unprecedented stability and precision. This project expects to generate new knowledge regarding the properties of materials that promote optical neuromodulation and new strategies to obtain long-term material stability in biologic ....Organic Bionics: Soft Materials to Solve Hard Problems in Neuroengineering. This project aims to combine innovations in organic conductors, nanotechnology, 3D biofabrication and neuroengineering to develop a bioelectronic system capable of wireless neuromodulation with unprecedented stability and precision. This project expects to generate new knowledge regarding the properties of materials that promote optical neuromodulation and new strategies to obtain long-term material stability in biological environments. The expected outcome is to generate new material design rules to facilitate wireless neuromodulation technologies in biomedical engineering. The project will position Australia as a leader in bionic devices by creating a new 3D bioprinting hub for low-cost fabrication of bioelectronic systems.Read moreRead less
Collaborative Sensing and Learning for Maritime Situational Awareness. We aim to demonstrate coordinated autonomous sensing of naval assets in dynamic maritime environments, reducing the operational load required to deliver a high quality maritime situational awareness. A realistic simulation based approach will help us develop novel artificial intelligence technology including: self-adaptive strategies for dynamic asset allocation, embedded smart sensing capabilities for naval observation syste ....Collaborative Sensing and Learning for Maritime Situational Awareness. We aim to demonstrate coordinated autonomous sensing of naval assets in dynamic maritime environments, reducing the operational load required to deliver a high quality maritime situational awareness. A realistic simulation based approach will help us develop novel artificial intelligence technology including: self-adaptive strategies for dynamic asset allocation, embedded smart sensing capabilities for naval observation systems and novel approaches to continuous collaborative learning from multi-spectral media. In addition to the emerging partnership between participants, the project will advance sovereign capability to develop maritime intelligence gathering technology for the Royal Australian Navy to underpin stability in our region. Read moreRead less
Switching Dynamics Approach for Distributed Global Optimisation . This project aims to create a breakthrough switching dynamics approach and new technology to speed up finding optimal solutions. It will develop a distributed switching dynamics based optimisation scheme for global optimisation problems in industrial big-data environments where timely decision making is required. It will result in a practical technology for industry optimisation problems such as economic energy dispatch in smart g ....Switching Dynamics Approach for Distributed Global Optimisation . This project aims to create a breakthrough switching dynamics approach and new technology to speed up finding optimal solutions. It will develop a distributed switching dynamics based optimisation scheme for global optimisation problems in industrial big-data environments where timely decision making is required. It will result in a practical technology for industry optimisation problems such as economic energy dispatch in smart grids and optimal charging and discharging tasks in a large network of electric vehicles, helping Australian power industry improve efficiency and security, as well as training the next generation scientists and engineers for Australia in this emerging field.Read moreRead less
Multiobjective Memetic Algorithms for Multi-task Symbolic Regression. This project aims at developing the new generation of symbolic regression methods using a yet unexplored way to represent mathematical functions. We will use memetic algorithms to create mathematical models for symbolic regression. Our memetic computing approach will be data-driven and will use multi-objective optimization and multi-task evolutionary computation for symbolic regression, addressing a core need of many areas of ....Multiobjective Memetic Algorithms for Multi-task Symbolic Regression. This project aims at developing the new generation of symbolic regression methods using a yet unexplored way to represent mathematical functions. We will use memetic algorithms to create mathematical models for symbolic regression. Our memetic computing approach will be data-driven and will use multi-objective optimization and multi-task evolutionary computation for symbolic regression, addressing a core need of many areas of science and technology. A large number of datasets will be investigated to benchmark the new methods. The expected outcomes will help support our national priorities with new data analytic capabilities. With a strong and interdisciplinary team in three continents, the project will attract international collaboration. Read moreRead less
Investigating differences in decision-making ability in older adults. This project aims to investigate how healthy ageing impacts decision making and its associated neural circuits using computation modelling and neurogenetic methods. Decision-making is a fundamental cognitive ability, allowing us to choose the best course of action. This project will investigate the relationship between genes and decision-making performance across the adult lifespan. Expected outcomes include a deeper understan ....Investigating differences in decision-making ability in older adults. This project aims to investigate how healthy ageing impacts decision making and its associated neural circuits using computation modelling and neurogenetic methods. Decision-making is a fundamental cognitive ability, allowing us to choose the best course of action. This project will investigate the relationship between genes and decision-making performance across the adult lifespan. Expected outcomes include a deeper understanding of how decision-making evolves in healthy ageing, and a tool based on genetic scores and computational modelling to predict an individual's trajectory of cognitive function. This could help identify individuals who are at risk for cognitive decline, which could then inform better interventions.Read moreRead less