Androgen receptor: A master regulator of lipid metabolism. This project aims to understand how male sex hormones, or androgens, affect the amount and metabolism of fats in normal body tissues. By integrating our multi-disciplinary expertise in androgen action, molecular biology, metabolism and bioinformatics with novel techniques and instrumentation, this collaboration expects to generate the first detailed picture of how fat metabolism is controlled by androgens in humans, and how closely this ....Androgen receptor: A master regulator of lipid metabolism. This project aims to understand how male sex hormones, or androgens, affect the amount and metabolism of fats in normal body tissues. By integrating our multi-disciplinary expertise in androgen action, molecular biology, metabolism and bioinformatics with novel techniques and instrumentation, this collaboration expects to generate the first detailed picture of how fat metabolism is controlled by androgens in humans, and how closely this relates to mice. Expected outcomes and benefits will be a new understanding of which aspects of fat metabolism are most influenced by androgens, and an ability to anticipate potential metabolic impacts of natural or pharmacological fluctuations in androgen levels in humans, laboratory animals and livestock.Read moreRead less
Low-energy electro-photonics: novel materials, devices and systems. This project aims to develop low-power technologies for programming and tuning photonic integrated circuits (PICs). By replacing thermal tuning, the project will reduce power consumption from watts to milliwatts, which also eliminates the thermal crosstalk that limits the complexity of today's PICs. The expected outcome will be the basis for a generic field-programmable photonic chip, which can be used to rapidly prototype desig ....Low-energy electro-photonics: novel materials, devices and systems. This project aims to develop low-power technologies for programming and tuning photonic integrated circuits (PICs). By replacing thermal tuning, the project will reduce power consumption from watts to milliwatts, which also eliminates the thermal crosstalk that limits the complexity of today's PICs. The expected outcome will be the basis for a generic field-programmable photonic chip, which can be used to rapidly prototype designs for production as full custom chips as part of a new Australian industry capability. The expected benefits will be a faster innovation cycle, greater adoption of photonic technologies, and support of research into, for example, neuromorphic optical processing, and advanced communications and sensing systems.Read moreRead less
Evolutionary diversity optimisation. This project aims to build up and establish the area of evolutionary diversity optimisation. The project will cover the design and application of evolutionary diversity optimisation methods to complex problems of significance and high national economic benefit and build up the theoretical foundations of these methods. The project is expected benefit decision makers by providing them a diverse set of high quality alternatives to choose from. This project will ....Evolutionary diversity optimisation. This project aims to build up and establish the area of evolutionary diversity optimisation. The project will cover the design and application of evolutionary diversity optimisation methods to complex problems of significance and high national economic benefit and build up the theoretical foundations of these methods. The project is expected benefit decision makers by providing them a diverse set of high quality alternatives to choose from. This project will allow them to make highly informed decisions and lead to more reliable solutions for optimisation problems, in areas of high economic impact such as manufacturing and supply chain management.Read moreRead less
Switching Dynamics Approach for Distributed Global Optimisation . This project aims to create a breakthrough switching dynamics approach and new technology to speed up finding optimal solutions. It will develop a distributed switching dynamics based optimisation scheme for global optimisation problems in industrial big-data environments where timely decision making is required. It will result in a practical technology for industry optimisation problems such as economic energy dispatch in smart g ....Switching Dynamics Approach for Distributed Global Optimisation . This project aims to create a breakthrough switching dynamics approach and new technology to speed up finding optimal solutions. It will develop a distributed switching dynamics based optimisation scheme for global optimisation problems in industrial big-data environments where timely decision making is required. It will result in a practical technology for industry optimisation problems such as economic energy dispatch in smart grids and optimal charging and discharging tasks in a large network of electric vehicles, helping Australian power industry improve efficiency and security, as well as training the next generation scientists and engineers for Australia in this emerging field.Read moreRead less
Multiobjective Memetic Algorithms for Multi-task Symbolic Regression. This project aims at developing the new generation of symbolic regression methods using a yet unexplored way to represent mathematical functions. We will use memetic algorithms to create mathematical models for symbolic regression. Our memetic computing approach will be data-driven and will use multi-objective optimization and multi-task evolutionary computation for symbolic regression, addressing a core need of many areas of ....Multiobjective Memetic Algorithms for Multi-task Symbolic Regression. This project aims at developing the new generation of symbolic regression methods using a yet unexplored way to represent mathematical functions. We will use memetic algorithms to create mathematical models for symbolic regression. Our memetic computing approach will be data-driven and will use multi-objective optimization and multi-task evolutionary computation for symbolic regression, addressing a core need of many areas of science and technology. A large number of datasets will be investigated to benchmark the new methods. The expected outcomes will help support our national priorities with new data analytic capabilities. With a strong and interdisciplinary team in three continents, the project will attract international collaboration. Read moreRead less
Investigating differences in decision-making ability in older adults. This project aims to investigate how healthy ageing impacts decision making and its associated neural circuits using computation modelling and neurogenetic methods. Decision-making is a fundamental cognitive ability, allowing us to choose the best course of action. This project will investigate the relationship between genes and decision-making performance across the adult lifespan. Expected outcomes include a deeper understan ....Investigating differences in decision-making ability in older adults. This project aims to investigate how healthy ageing impacts decision making and its associated neural circuits using computation modelling and neurogenetic methods. Decision-making is a fundamental cognitive ability, allowing us to choose the best course of action. This project will investigate the relationship between genes and decision-making performance across the adult lifespan. Expected outcomes include a deeper understanding of how decision-making evolves in healthy ageing, and a tool based on genetic scores and computational modelling to predict an individual's trajectory of cognitive function. This could help identify individuals who are at risk for cognitive decline, which could then inform better interventions.Read moreRead less
A more sound approach to the neurobiology of language. How does the brain attain spoken language? Current neurobiological models assume either implicitly or explicitly that there is no relationship between a word's sound and its meaning. Yet considerable evidence shows this strong assumption about the arbitrariness of language is invalid. This project will use a combination of behavioural, neuroimaging and computational studies to characterise how the brain processes statistical regularities in ....A more sound approach to the neurobiology of language. How does the brain attain spoken language? Current neurobiological models assume either implicitly or explicitly that there is no relationship between a word's sound and its meaning. Yet considerable evidence shows this strong assumption about the arbitrariness of language is invalid. This project will use a combination of behavioural, neuroimaging and computational studies to characterise how the brain processes statistical regularities in sound-to-meaning correspondences as probabilistic cues to attain spoken language. The outcome will be a better neural account of language comprehension and production. The benefit of this new account will be a stronger basis for assessment and treatment of developmental and acquired language impairments.Read moreRead less