Functional characterisation of neurons derived from embryonic stem cells and NS cells. The ability to obtain specific neurons from NS cells will revolutionise the study of nerve function, will allow the establishment of much-improved models for discovery of new drugs, and will define how enriched populations of neural cells can be obtained for applications in treatment of neurodegenerative diseases. The project will provide vital data for the emerging biotechnology industry associated will appl ....Functional characterisation of neurons derived from embryonic stem cells and NS cells. The ability to obtain specific neurons from NS cells will revolutionise the study of nerve function, will allow the establishment of much-improved models for discovery of new drugs, and will define how enriched populations of neural cells can be obtained for applications in treatment of neurodegenerative diseases. The project will provide vital data for the emerging biotechnology industry associated will applications of stem cell biology, and will stimulate clinical researchers to investigate the therapeutic potential of cell derived from NS cells.Read moreRead less
Pancreatic Differentiation of Cord Blood Stem Cells using Smart Surfaces. Cord blood cells obtained at the time of delivery of a baby are a valuable resource that have the potential to develop into many cell types. This Project entails attaching stem cells derived from cord blood to appropriate 3 dimensional smart surfaces, and examining the ability of such cells to develop into insulin-producing cells. An understanding of how to coax stem cells, seeded on to smart surfaces, to develop into ma ....Pancreatic Differentiation of Cord Blood Stem Cells using Smart Surfaces. Cord blood cells obtained at the time of delivery of a baby are a valuable resource that have the potential to develop into many cell types. This Project entails attaching stem cells derived from cord blood to appropriate 3 dimensional smart surfaces, and examining the ability of such cells to develop into insulin-producing cells. An understanding of how to coax stem cells, seeded on to smart surfaces, to develop into mature cells with different functions will enhance our ability to understand how cells develop. As well, it enhance the potential usefulness of cord blood for research purposes. Read moreRead less
Predictive Assessment Tool for Beach Conditions Using Video Imaging and Neural Network Analysis. Beaches are vital part of Australian lifestyle and economic development. Monitoring of variable beach conditions is vital for beach safety and for management of storm erosion. The aim of this project is to develop an assessment tool which will permit a rating system of beach conditions both from an environmental as well as a leisure aspect. This tool will be developed into a software analysis system ....Predictive Assessment Tool for Beach Conditions Using Video Imaging and Neural Network Analysis. Beaches are vital part of Australian lifestyle and economic development. Monitoring of variable beach conditions is vital for beach safety and for management of storm erosion. The aim of this project is to develop an assessment tool which will permit a rating system of beach conditions both from an environmental as well as a leisure aspect. This tool will be developed into a software analysis system which will include components of artificial intelligence to enable the system to use feedback loops to create a better prediction of the beach morphology relative to the breaking wave characteristics.Read moreRead less
Neurons isolated from embryonic stem cells as functional models for drug discovery. By using gene expression-based selection criteria embryonic stem cells can be driven to differentiate into specific neuronal lineages which show many of the morphological characteristics and immunocytochemical features of neurons in culture. There is, however, comparatively little evidence indicating that these stem cell-derived neurons actually behave as neurons. Our aim is to characterise and contrast four ne ....Neurons isolated from embryonic stem cells as functional models for drug discovery. By using gene expression-based selection criteria embryonic stem cells can be driven to differentiate into specific neuronal lineages which show many of the morphological characteristics and immunocytochemical features of neurons in culture. There is, however, comparatively little evidence indicating that these stem cell-derived neurons actually behave as neurons. Our aim is to characterise and contrast four neuronal cell cultures established with gene-based selection criteria. These cultures will be characterised by gene expression, immunocytochemistry, radiolabelled neurotransmitter release, electrophysiology and Ca2+ imaging studies. This study will highlight the functional effects of gene selection procedures upon stem cell-derived neurons.Read moreRead less
DEVELOPING A SMART FIRE RISK ADVISORY SYSTEM USING FIRE MODELLING AND KNOWLEDGE-BASED SYSTEMS TECHNOLOGIES. This project aims to develop a prototype fire risk advisory system for fire prevention and protection. Intelligent knowledge-based systems technologies will be tailored to provide a standardised approach for fire risk analysis by using collective expertise of fire engineers and fire modelling. This project will lead to a significant advancement to the development of intelligent systems tec ....DEVELOPING A SMART FIRE RISK ADVISORY SYSTEM USING FIRE MODELLING AND KNOWLEDGE-BASED SYSTEMS TECHNOLOGIES. This project aims to develop a prototype fire risk advisory system for fire prevention and protection. Intelligent knowledge-based systems technologies will be tailored to provide a standardised approach for fire risk analysis by using collective expertise of fire engineers and fire modelling. This project will lead to a significant advancement to the development of intelligent systems techniques for industrial applications and provide a better fire risk analysis tool for fire protection and preventions with the benefit of reduced risk for buildings.
Read moreRead less
OPTIMISATION OF COMPACT BOILING HEAT EXCHANGERS USING ARTIFICIAL NEURAL NETWORK. Compact heat exchangers are increasingly considered for duties in many industrial applications, involving phase change processes of boiling and condensation. In many cases such applications are completely new and no previous experience or information is available for constructive design of compact heat exchangers. This project aims to develop a commercially-viable design methodology that will be innovative and novel ....OPTIMISATION OF COMPACT BOILING HEAT EXCHANGERS USING ARTIFICIAL NEURAL NETWORK. Compact heat exchangers are increasingly considered for duties in many industrial applications, involving phase change processes of boiling and condensation. In many cases such applications are completely new and no previous experience or information is available for constructive design of compact heat exchangers. This project aims to develop a commercially-viable design methodology that will be innovative and novel with in mind of robust and speedy computations of key design parameters of compact boiling heat exchangers through the artificial neural networks (ANN) model and maintaining the inherent accuracy associated with the solutions of the boiling flow and heat transfer processes from computational fluid dynamics (CFD) and validated using experimental data. It will provide a cutting edge to the Industry Partner to compete successfully on the local and global market fronts in designing and manufacturing compact boiling heat exchangers.Read moreRead less
Why is the photosynthetic CO2-fixing enzyme, Rubisco, so inefficient? Dissection of the catalytic chemistry by computational simulation and experimental testing. Fixation of CO2 by the enzyme Rubisco during photosynthesis produces organic compounds which feed all life. Despite this critical role, Rubisco catalyses its reaction sluggishly and, worse, discriminates poorly between CO2 and O2, leading to useless products. Our combined expertise equips us to analyse Rubisco's mechanism using quantum- ....Why is the photosynthetic CO2-fixing enzyme, Rubisco, so inefficient? Dissection of the catalytic chemistry by computational simulation and experimental testing. Fixation of CO2 by the enzyme Rubisco during photosynthesis produces organic compounds which feed all life. Despite this critical role, Rubisco catalyses its reaction sluggishly and, worse, discriminates poorly between CO2 and O2, leading to useless products. Our combined expertise equips us to analyse Rubisco's mechanism using quantum-chemical methods and then test predictions experimentally. We will capitalise on our previous successful studies of Rubisco by addressing emergent issues which are the keys to understanding catalytic efficiency and CO2/O2 selectivity: the roles of a carbamylated lysine; the way CO2 addition is rendered irreversible; and the spin inversion inherent in O2 addition.Read moreRead less
New Techniques for Structural Biology and Directed Molecular Evolution. This PhD program will equip an Australian graduate with advanced training in techniques in molecular genetics and protein chemistry that are currently in high demand by the biotechnology industry, and also provide him/her with direct experience of an industrial R&D laboratory environment. Moreover, it will establish a basis for further collaboration between a leading University-based research laboratory and an established R& ....New Techniques for Structural Biology and Directed Molecular Evolution. This PhD program will equip an Australian graduate with advanced training in techniques in molecular genetics and protein chemistry that are currently in high demand by the biotechnology industry, and also provide him/her with direct experience of an industrial R&D laboratory environment. Moreover, it will establish a basis for further collaboration between a leading University-based research laboratory and an established R&D company that will lead to development of new techniques for use in biotechnology in Australia and overseas.Read moreRead less
Ageing wild vertebrates from their DNA: an investigation using Humpback Whales as an example. The aim of this project is to estimate the age of individually identified humpback whales and the age structure of humpback whale populations using non-lethal, innovative molecular techniques. Populations of humpback whales in the Southern Hemisphere are slowly recovering from intensive whaling during the 20th century. This project is significant because it will provide the first comparative information ....Ageing wild vertebrates from their DNA: an investigation using Humpback Whales as an example. The aim of this project is to estimate the age of individually identified humpback whales and the age structure of humpback whale populations using non-lethal, innovative molecular techniques. Populations of humpback whales in the Southern Hemisphere are slowly recovering from intensive whaling during the 20th century. This project is significant because it will provide the first comparative information on the age structure of these populations, resulting in improved estimation of recovery and population dynamics of long-lived vertebrates. The results of this project will revolutionise research on ageing in whales and dolphins, providing an important alternative to lethal scientific whaling.Read moreRead less