Respiratory failure at birth is a major cause of death and disease in newborn infants. At birth the airways must be cleared of liquid to allow the inhalation of air, but, little is known about the process of lung aeration, because it has not been possible to observe or measure it. We have developed imaging and analytical techniques to observed and measure lung aeration. We will determine ventilation procedures that promote uniform lung aeration and minimise lung injury in ventilated infants.
Defining Regional Lung Mechanics To Improve Lung Protective Ventilation Strategies In Newborn Infants
Funder
National Health and Medical Research Council
Funding Amount
$287,321.00
Summary
Over 3000 newly born infants require mechanical ventilation in Australia every year. The majority are very premature infants. About 30% of ventilated infants develop serious ventilator induced lung injury. Minimising such lung injury with improved techniques of ventilation which can protect the lung from injury will reduce the considerable short and long term health burden of this population.
Multicentre Trial Of Calcium Channel Blocker Versus Calcium Channel Blocker Plus Cox2 Inhibitor In Preterm Labour
Funder
National Health and Medical Research Council
Funding Amount
$644,130.00
Summary
Preterm birth is a major problem in our society, and has enormous consequences for parents and children. It also has a major impact on scarce financial resources. When women present in preterm labor, current therapies have only limited success in stopping contractions and postponing birth. They have not been shown to reduce the rates of the serious neonatal problems associated with prematurity. This project will be coordinated in Newcastle, N.S.W., and will involve major perinatal centres throug ....Preterm birth is a major problem in our society, and has enormous consequences for parents and children. It also has a major impact on scarce financial resources. When women present in preterm labor, current therapies have only limited success in stopping contractions and postponing birth. They have not been shown to reduce the rates of the serious neonatal problems associated with prematurity. This project will be coordinated in Newcastle, N.S.W., and will involve major perinatal centres throughout Australia, along with overseas centres. It will test a new combination of drugs for their ability to postpone delivery in women presenting with preterm labour. It is postulated that the combination of drugs will be more effective than existing therapies. The drugs used in the trial are Nifedipine and Rofecoxib. Complications of prematurity include neonatal death, cerebral palsy, visual and hearing impairment, and chronic lung disease. These complications are most significant in extremely premature infants - in particular, those under 28 weeks gestation at the time of their delivery. For this reason, the study will focus only on women presenting in labour below 28 weeks. The ability to stop labour is important, but the main aim of any treatment for preterm labour is to reduce the rates of neonatal death and handicap. Babies born to women enrolled in this study will be followed for a period of one year after birth to assess their outcomes. It is our hypothesis that the combination of Rofecoxib and Nifedipine will result in lower rates of death and handicap in babies than Nifedipine alone. In addition, we will examine the rates of side effects in women receiving therapy. Currently used therapies, including intravenous ventolin, have high rates of maternal side effects. Nifedipine and Rofecoxib have both been shown to have low rates of maternal side effects.Read moreRead less
A Study Of The Impact Of Treating Electrographic Seizures In Term Or Near-term Infants With Neonatal Encephalopathy
Funder
National Health and Medical Research Council
Funding Amount
$1,365,184.00
Summary
Seizures in the newborn infant are common and may be harmful to the developing brain. They are not always recognised. This study investigates whether or not treating all seizures detected using a bedside brain activity monitor improves developmental outcome, compared to just treating seizures that doctors recognise.
Improving The Neonatal Transition In Infants With A Congenital Diaphragmatic Hernia
Funder
National Health and Medical Research Council
Funding Amount
$551,644.00
Summary
Congenital diaphragmatic hernia is a common congenital abnormality and occurs when the diaphragm fails to separate the abdominal and thoracic compartments before birth. This prevents the lung from growing properly and so at birth, the lung is unable to take over the role of gas exchange without considerable assistance. As a result, these infants are at high risk of death or significant disability and this application is focused on improving care and reducing morbidity in these infants.
We aim to predict neurodevelopmental disability in babies born very preterm, earlier and more accurately than currently possible, by identifying structural and functional connectivity features that correlate with clinical measures of motor and neurodevelopmental functions. To do this we will use brain magnetic resonance imaging (MRI), dense array electroencephalography (EEG) and structured clinical neurodevelopmental assessments to provide a cutting edge view of the state of brain development.
Discovery Early Career Researcher Award - Grant ID: DE240100635
Funder
Australian Research Council
Funding Amount
$448,801.00
Summary
Understanding the development of lifestyle behaviours in early childhood. This project adopts novel statistical modelling and machine learning approaches to understand the development of lifestyle behaviours in early childhood. Despite the pivotal role of lifestyle behaviours in influencing health and quality of life, little research exists on lifestyle behaviours in early childhood. This project will establish a comprehensive understanding of lifestyle behaviours in early childhood by identifyi ....Understanding the development of lifestyle behaviours in early childhood. This project adopts novel statistical modelling and machine learning approaches to understand the development of lifestyle behaviours in early childhood. Despite the pivotal role of lifestyle behaviours in influencing health and quality of life, little research exists on lifestyle behaviours in early childhood. This project will establish a comprehensive understanding of lifestyle behaviours in early childhood by identifying key developmental time points, mechanisms of behavioural change, and children at risk of developing poor lifestyle behaviours. The project will inform strategies and policies to optimise lifestyle behaviours from the start of life and showcase the capabilities of novel methods in advancing behavioural epidemiology.Read moreRead less
From The Synchrotron To The Clinic: Translation Of A Novel Functional Lung Imaging Technology
Funder
National Health and Medical Research Council
Funding Amount
$891,834.00
Summary
Our team has recently developed a synchrotron technology with a startling capacity for dynamic functional imaging that can act as a sensitive regional indicator of lung disease. We will demonstrate that this technology can be translated from the synchrotron to the lab and eventually the clinic. We will provide proof of this concept by the application of this technology to emphysema, asthma, lung cancer, cystic fibrosis lung disease and neonatal resuscitation.
A Community-based Cluster Randomized Controlled Trial In Rural Bangladesh To Evaluate The Impact Of The Use Of Iron/folic Acid Supplements Early In Pregnancy On The Risk Of Neonatal MortalityBACKGROUND An Effective Program Of Antenatal Iron/folic Ac
Funder
National Health and Medical Research Council
Funding Amount
$2,564,922.00
Summary
This community-based trial in rural Bangladesh will determine if iron/folic acid supplementation commencing in the first trimester of pregnancy significantly reduces newborn deaths, and whether this approach is cost-effective. This trial has the potential to inform international public health policy about the importance of starting antenatal iron/folic acid supplementation early to improve neonatal survival, and to help countries reach their child survival Millennium Development Goal
Discovery Early Career Researcher Award - Grant ID: DE240100452
Funder
Australian Research Council
Funding Amount
$364,774.00
Summary
TransformUs Higher Ed: Developing confident, 'classroom-ready' graduates . The impact of the COVID-19 pandemic on children has been far-reaching. Many students have fallen behind academically, are experiencing mental health challenges and have critically low levels of physical activity. These issues have become a global research priority, the focus of national and state policies, and urgently need addressing. This project offers a novel initial teacher education program that integrates meaningfu ....TransformUs Higher Ed: Developing confident, 'classroom-ready' graduates . The impact of the COVID-19 pandemic on children has been far-reaching. Many students have fallen behind academically, are experiencing mental health challenges and have critically low levels of physical activity. These issues have become a global research priority, the focus of national and state policies, and urgently need addressing. This project offers a novel initial teacher education program that integrates meaningful physical activity into classroom learning to address critical classroom challenges, exacerbated by COVID-19. The empirical findings are expected to generate new knowledge and practices to strengthen teaching degrees from a robust evidence base and benefit the learning and health outcomes of all Australian students.
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