The Relationship Between Osteoporosis And Diabetes: Exploring The Bone-metabolism Interface
Funder
National Health and Medical Research Council
Funding Amount
$124,676.00
Summary
Osteoporosis and diabetes are two common conditions that affect many Australians. Diabetes patients have an increased risk of fractures, however the underlying mechanisms for this increased fracture risk is unknown. We hypothesise that there are changes in the bone remodelling as a result of increased insulin levels (as seen in type 2 diabetes) and will explore the factors that contribute to the increased fracture risk and examine how treatments can reduce fracture rates.
Control Of Musculoskeletal Function And Glucose Metabolism By Androgens In Men
Funder
National Health and Medical Research Council
Funding Amount
$245,031.00
Summary
Male sex hormone or androgen deficiency (AD) is a common, but under-diagnosed condition. AD decreases general well being and contributes to muscle weakness, bone fragility and weight gain. By using cutting edge imaging and molecular technologies, we will help to explain the underlying mechanisms of how AD leads to these negative effects. This should ultimately lead to reduction of adverse outcomes of AD, which include fractures and cardiovascular events.
The prevalence of type 2 diabetes in increasing worldwide, the International Diabetes Federation predicting 435 million will have diabetes in 2030. The major driver of the diabetes epidemic is obesity. There is strong evidence linking type 2 diabetes and obesity to an increased risk of cancer. However, the exact mechanism promoting cancer development in obese and diabetic individuals is not clear. This project will examine the effects of high insulin levels on cancer development and progression.
Role Of UBL-5 In Mitochondrial Function And Glucose Metabolism
Funder
National Health and Medical Research Council
Funding Amount
$647,539.00
Summary
Type 2 diabetes is caused by insulin resistance, a condition that is characterised by the inability of insulin to elicit its normal function to lower blood sugar levels. The cause of insulin resistance is not known. In this study we will determine the role of a novel gene called UBL-5 to elicit insulin resistance in muscle and fat by generating genetically-induced models in which this gene has been deleted. By understanding the role of UBL-5 in insulin resistance, better therapeutic strategies c ....Type 2 diabetes is caused by insulin resistance, a condition that is characterised by the inability of insulin to elicit its normal function to lower blood sugar levels. The cause of insulin resistance is not known. In this study we will determine the role of a novel gene called UBL-5 to elicit insulin resistance in muscle and fat by generating genetically-induced models in which this gene has been deleted. By understanding the role of UBL-5 in insulin resistance, better therapeutic strategies can be developed to treat Type 2 diabetes.Read moreRead less
How Intra-abdominal Transplantation Of Subcutaneous Adipose Tissue Prevents High-fat Diet-induced Insulin Resistance And Obesity
Funder
National Health and Medical Research Council
Funding Amount
$358,465.00
Summary
In obese humans, storing excess fat within the abdomen is associated with the development of adult-onset diabetes and cardiovascular disease. However, the mechanisms linking intra-abdominal fat accumulation with these diseases are not well understood. We have studied intra-abdominal fat accumulation in mice using a transplant model, and we have found that transplanting subcutaneous fat intra-abdominally prevents diet-induced obesity and glucose intolerance. We aim to investigate the underlying m ....In obese humans, storing excess fat within the abdomen is associated with the development of adult-onset diabetes and cardiovascular disease. However, the mechanisms linking intra-abdominal fat accumulation with these diseases are not well understood. We have studied intra-abdominal fat accumulation in mice using a transplant model, and we have found that transplanting subcutaneous fat intra-abdominally prevents diet-induced obesity and glucose intolerance. We aim to investigate the underlying mechanisms.Read moreRead less