Optimising Non-invasive Ventilation At Birth For Preterm Infants
Funder
National Health and Medical Research Council
Funding Amount
$735,912.00
Summary
Infants born very premature require respiratory support at birth to make the transition to newborn life. As these infants are very immature and prone to injury, modern respiratory care strategies utilise the least invasive approaches mainly applied using a facemask. However, we have discovered that the larynx is closed at birth and thereby prevents air from entering the lung. This application is focussed on optimising the efficiency of facemask ventilation at birth and stimulating breathing.
Treating Insomnia Co-morbid With Obstructive Sleep Apnoea: A Randomized Controlled Clinical Effectiveness Trial.
Funder
National Health and Medical Research Council
Funding Amount
$600,869.00
Summary
Obstructive Sleep Apnoea (OSA) is a common but serious sleep disorder. Continuous positive airways pressure (CPAP) therapy can be very effective in treating OSA. We have found that many patients with OSA also suffer from insomnia, and this can make it hard for them to begin CPAP therapy and hard for them to stick to it. This trial will examine the effect of treating insomnia concurrently with CPAP, with the expectation that overall treatment outcomes will improve.
Continuous Positive Airway Pressure For Obstructive Sleep Apnoea In Quadriplegia: A Randomised Trial
Funder
National Health and Medical Research Council
Funding Amount
$307,677.00
Summary
Each year in Australia 260 people sustain a SCI, with over half losing full function in their arms and legs (quadriplegia). In addition to the primary disability, there is a very high rate of Obstructive Sleep Apnoea (OSA). This project is a multi-national randomized controlled trial to treat OSA in acute injury with a nasal mask during sleep. The study will determine if we can help people live better after injury by improving sleep, quality of life, memory and attention.
The Interaction Between Obstructive Sleep Apnea And Cardiovascular Risk Factors On Cardiovascular Disease
Funder
National Health and Medical Research Council
Funding Amount
$1,263,050.00
Summary
Cardiovascular (CV) disease and obstructive sleep apnoea (OSA) are common causes of morbidity and mortality. OSA is an independent risk factor for CV disease but little is known about which patients with OSA are likely to develop CV disease, and the interaction between OSA and other CV risk factors. We seek to better understand this interaction by exploring which of 4,100 well characterised patients in the West Australian Sleep Health Study (WASHS) 2005-2010 have developed CV disease.
Separating The Adverse Neurodevelopmental Consequences Of Mechanical Ventilation And Postnatal Steroids In Preterm Lambs
Funder
National Health and Medical Research Council
Funding Amount
$1,752,863.00
Summary
Extremely premature infants often develop severe breathing difficulties and need the help of a machine to breathe. Certain steroids help to mature the lung and allow the baby to breathe on his own without help. However, both steroids and long periods on breathing machines may interfere with normal brain development. This study will help doctors to weigh up the long-term risks and benefits of giving a baby steroids to help them breathe on their own versus continuing mechanical ventilation without ....Extremely premature infants often develop severe breathing difficulties and need the help of a machine to breathe. Certain steroids help to mature the lung and allow the baby to breathe on his own without help. However, both steroids and long periods on breathing machines may interfere with normal brain development. This study will help doctors to weigh up the long-term risks and benefits of giving a baby steroids to help them breathe on their own versus continuing mechanical ventilation without steroids.Read moreRead less
The Sleep Apnea Cardio Vascular Endpoints (SAVE) Study
Funder
National Health and Medical Research Council
Funding Amount
$1,177,047.00
Summary
Obstructive sleep apnea (OSA) affects 7% of the population and is increasing with the global epidemic of obesity. Research suggests that OSA may be a cause of premature cardiovascular (CV) disease, but definitive proof is lacking. This 5-year trial will answer this question by comparing the rate of CV events (eg stroke, heart attack) in OSA patients who are treated, versus those not treated, with CPAP. The results may lead to a new medical approach to the prevention of CV disease.
Obstructive sleep apnea (OSA) affects 7% of the population and is increasing with the global epidemic of obesity. Research suggests that OSA may be a cause of premature cardiovascular (CV) disease, but definitive proof is lacking. This 5-year trial will answer this question by comparing the rate of CV events (eg stroke, heart attack) in OSA patients who are treated, versus those not treated, with CPAP. The results may lead to a new medical approach to the prevention of CV disease.
Clinical Trial Of Minimally-invasive Surfactant Therapy
Funder
National Health and Medical Research Council
Funding Amount
$1,172,978.00
Summary
This proposal is for funding of a clinical trial investigating a new and less-invasive technique of giving surfactant to improve lung function in preterm babies born between 25 and 28 weeks gestation. The trial will examine whether giving surfactant using the less invasive method results in better outcomes, including a reduction in time on respiratory support, and higher survival without chronic oxygen dependency.