Targeted Direct Reprogramming Of Adult Cardiac Fibroblasts To Functional Cardiomyocytes
Funder
National Health and Medical Research Council
Funding Amount
$618,493.00
Summary
Ischemic Heart Disease (IHD) is the leading cause of mortality in Australia, accounting for ~ 22,000 Australians each year. Regenerating a damaged heart remains a major challenge, requiring us to rethink the problem and develop new innovative and readily translatable strategies. This proposal will develop a targeted, cell-free approach to directly reprogram resident cardiac fibroblasts into functional cardiomyocytes post a heart attack, paving the way for a new therapy for IHD sufferers.
Mechanically-restricted Percutaneous Gene Therapeutic Solutions For Heart Failure.
Funder
National Health and Medical Research Council
Funding Amount
$187,000.00
Summary
We have developed a novel system for the localized delivery of specialised genes to the heart in order to improve contractility and function of a failing heart. Many genes, for reasons of toxicity, clearance, or uptake, require direct delivery to the target region without spillover to the systemic circulation. Our system addresses these issues by isolating the local circulation of the target organ and directly delivering the agent with minimal systemic loss and improved delivery and uptake effic ....We have developed a novel system for the localized delivery of specialised genes to the heart in order to improve contractility and function of a failing heart. Many genes, for reasons of toxicity, clearance, or uptake, require direct delivery to the target region without spillover to the systemic circulation. Our system addresses these issues by isolating the local circulation of the target organ and directly delivering the agent with minimal systemic loss and improved delivery and uptake efficiency, while minimizing potentially dangerous and toxic systemic effects.Read moreRead less