Feasibility Of Using Pre-hospital Point-of-care Troponin And Paramedic Risk Assessment In Patients With Chest Pain Without ST-elevation
Funder
National Health and Medical Research Council
Funding Amount
$132,743.00
Summary
Non-traumatic chest pain is the leading cause of ambulance services use in Victoria. Currently, there is no protocol for paramedics to determine which patients are high risk and suffering a minor heart attack, which results in delays in treatment. The aim of this project is to assess the feasibility of a risk assessment tool, including the use of point-of-care blood testing to detect heart attacks, to accurately risk stratify chest pain patients in the pre-hospital setting.
CAMERA-MRI II: Catheter Ablation Versus Medical Rate Control In Atrial Fibrillation With Systolic Heart Failure And Myocardial Fibrosis - An MRI Guided Multi-Centre Randomised Controlled Trial
Funder
National Health and Medical Research Council
Funding Amount
$132,743.00
Summary
Atrial fibrillation (AF) is an irregular heart rhythm commonly seen in patients with a weakened heart muscle. Symptoms and heart function may improve if the rhythm is restored through a catheter ablation procedure. This study will assess whether this procedure improves the function of the heart in those with AF where there is weakness and scarring of the heart. We hope to better determine which patients are best suited and will derive the most benefit from this procedure.
The Effect Of Renal Transplantation And Extended Hours Haemodialysis On Cardiac MRI And Biomarkers.
Funder
National Health and Medical Research Council
Funding Amount
$107,750.00
Summary
Patients with chronic kidney disease (CKD) are at increased risk for cardiovascular disease (CVD). Asymptomatic patients demonstrate changes in cardiac imaging and elevation of cardiac biomarkers which predict outcome. This study will investigate serial cardiac imaging and cardiac biomarkers in patients undergoing live donor renal transplantation and extended hours haemodialysis. Results will enhance our understanding of cardiovascular disease in CKD leading to improved patient outcomes.
Platelet Derived Growth Factor Mediated Activation And Rejuvenation Of Endogenous Cardiac Stem Cells
Funder
National Health and Medical Research Council
Funding Amount
$102,345.00
Summary
The burden of heart failure is underpinned by the heart’s limited capacity for self-repair after injury. Recent evidence shows that PDGF can improve heart function by activating and rejuvenating resident heart stem cells. This project will build on over a decade of preliminary work in mice, validating our results in a preclinical large animal model. Outcomes of this project include expedited progression of this promising therapy where thousands of heart failure patients could one-day benefit.
Revealing The Roadblocks: Timely ST-segment Elevation Myocardial Infarction (STEMI) Management Over Total Ischaemic Time In Metropolitan, Regional And Rural Victoria.
Funder
National Health and Medical Research Council
Funding Amount
$72,768.00
Summary
Cardiovascular disease kills one Australian every 12 minutes. Coordinated and prompt medical treatment of heart attack is essential in preventing mortality. This study will identify contributing factors of delay from a frontline clinician and hospital perspective. It is anticipated by understanding the impact these factors have on the delivery of heart attack care, an evidence base is built to support the various clinicians involved, and improve this complex process of care across Victoria.
Double Blind, Randomised Controlled Trial Assessing The Efficacy Of Endothelin-1 Receptor Antagonism In Preventing Peri-procedural Myonecrosis In Patients With Non-ST Elevation Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention
Funder
National Health and Medical Research Council
Funding Amount
$124,608.00
Summary
While the focus in the treatment of coronary artery disease has primarily been on the large vessels in the heart, vessels of small calibre may also play a significant role in patients with angina, heart attack, and muscle injury related to a stenting procedure.This project aims elucidate the possible mechanisms which cause dysfunction in these small vessels. I also hope to find a treatment strategy which may benefit patients with small vessel problems and thus improve their overall outcome.
Physiology Of Acute Coronary Syndromes: Focus On Microvascular Dysfunction
Funder
National Health and Medical Research Council
Funding Amount
$90,029.00
Summary
Heart attacks,caused by blocked coronary arteries are an important public health concern.There are patients who have a worse outcome due to damage of small blood vessels that cannot be visualised with normal testing. New blood tests and invasive technology are available that can assess these small vessels.We plan to use these techniques to observe the extent of small blood vessel damage in patients with heart attacks and hope this will lead to better understanding of heart attacks and improved t ....Heart attacks,caused by blocked coronary arteries are an important public health concern.There are patients who have a worse outcome due to damage of small blood vessels that cannot be visualised with normal testing. New blood tests and invasive technology are available that can assess these small vessels.We plan to use these techniques to observe the extent of small blood vessel damage in patients with heart attacks and hope this will lead to better understanding of heart attacks and improved treatments.Read moreRead less
Prediction Of Ventricular Arrhythmias And Prevention Of Sudden Cardiac Death Following Revascularised Acute Myocardial Infarction.
Funder
National Health and Medical Research Council
Funding Amount
$117,270.00
Summary
Acute myocardial infarction (AMI) is a leading cause of death in Australia. Patients with coronary artery disease and impaired left ventricular function are at increased risk of heart failure, reinfarction and sudden cardiac death (SCD). This research will evaluate optimal methods to identify patients at risk for SCD following AMI using echocardiographic, MRI, and electrophysiological characteristics, and improve survival by early identification and management of these high-risk patients.
Cardiac Matrix Modulation By Platelet Derived Growth Factor To Improve Outcomes After Myocardial Infarction
Funder
National Health and Medical Research Council
Funding Amount
$96,009.00
Summary
This project is directed towards improving the poor outcome in patients suffering heart failure. Whilst rates of some cardiovascular diseases are decreasing, heart failure incidence is rising significantly. Once end stage heart failure occurs, heart transplantation is possible but has several limitations including organ availability. This research into cardiac regeneration could potentially lead to a significant therapy for heart failure, thereby translating into life-saving outcomes.