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Anaemia In The Elderly: Epidemiology, Causes, Consequences And Optimal Transfusion Strategies
Funder
National Health and Medical Research Council
Funding Amount
$128,224.00
Summary
Anaemia in the elderly (AE) is a common and increasing issue, which is often treated with blood transfusions. This project aims to investigate the causes and risk factors of patients who develop AE, and the impact of AE on health outcomes. The results will help define appropriate haemoglobin thresholds for AE, and provide information to develop appropriate guidelines for AE and transfusion management in the elderly.
Myelodysplastic syndromes (MDS) are disorders of blood-forming stem cells characterised by low blood counts and progression to acute leukaemia. Epigenetics refers to changes in gene expression without changing the underlying DNA sequence. More than half of MDS have mutation/s in epigenetic regulators, providing evidence that epigenetics is an important contributor to the disease. The goal of this project is to better understand how epigenetics contribute to MDS and discovery of new therapies.