Risks And Benefits Of Breast Cancer Screening: BreastScreen WA Cohort Study Of Overdiagnosis And Breast Cancer Mortality
Funder
National Health and Medical Research Council
Funding Amount
$201,524.00
Summary
Overdiagnosis is the major downside of screening for breast cancer. This occurs when screening detects cancers that would not have caused symptoms in the woman's lifetime. This study aims to quantify the amount of overdiagnosis that occurs in the Australian breast cancer screening program (BreastScreen)
Understanding Causes Of The Rising Incidence Of Thyroid Cancer – What Can Mutations In The BRAF Oncogene Tell Us About Causes And Diagnostic Pathways For Thyroid Cancer?
Funder
National Health and Medical Research Council
Funding Amount
$610,222.00
Summary
The occurrence of thyroid cancer has increased rapidly over the last 25 years but the cause is unknown. The increase may reflect ‘over-diagnosis’ of less harmful cancers or greater exposure to causes of this cancer. Evidence suggests that a gene mutation (BRAF) in thyroid cancers is important in understanding the drivers of the increase. This study will examine the increase in thyroid cancer by investigating causes and diagnostic pathways considering the presence or absence of BRAF mutations.
Randomised Controlled Trial Of HPV Self-sampling For Improving Participation In Cervical Screening: The IPAP Trial
Funder
National Health and Medical Research Council
Funding Amount
$534,461.00
Summary
Effectiveness of cervical cancer screening relies on maximising participation. Unlike a Pap test, an HPV test may be self-collected and this may overcome some of the barriers to Pap testing. Overseas trials have found higher uptake for HPV self-sampling (between 3-30%) compared with Pap test reminder letters. We will conduct the first randomised trial in Australia comparing home-based HPV self-sampling with a reminder letter, to evaluate whether this improves participation and followup.
Evaluation Of Outcomes And Cost-effectiveness Of Implementing Next Generation Human Papillomavirus (HPV) Vaccination And Associated Primary HPV-based Cervical Cancer Screening Strategies In Australia
Funder
National Health and Medical Research Council
Funding Amount
$697,071.00
Summary
This project involves using simulation modelling to predict the effect of the next generation human papillomavirus (HPV) vaccine, which will protect against infection with more strains of HPV. The investigators will use large datasets garnered from around the world to inform the assessment of the cost-effectiveness of this new vaccine in Australia and other key countries, and also to assess whether cervical screening will need to change in the future to account for the introduction of the new va ....This project involves using simulation modelling to predict the effect of the next generation human papillomavirus (HPV) vaccine, which will protect against infection with more strains of HPV. The investigators will use large datasets garnered from around the world to inform the assessment of the cost-effectiveness of this new vaccine in Australia and other key countries, and also to assess whether cervical screening will need to change in the future to account for the introduction of the new vaccine.Read moreRead less
Infant Thyroid Hormone Levels And Long-term Child Educational Outcomes
Funder
National Health and Medical Research Council
Funding Amount
$490,495.00
Summary
Adequate levels of newborn thyroid hormones are essential for brain development.Newborn screening for thyroid hormone deficiency ensures early identification, treatment & prevention of severe intellectual disability.But there is clinical uncertainty in mildly abnormal levels.We will assess thyroid hormone levels & subsequent educational outcomes in 1.5M Australian babies.There is potential to identify infants who, without treatment, may suffer longterm disability & lower educational achievement