Microchip Impedance Biosensor for Biomedical Diagnostics. This research proposal uses an innovative engineering approach based on novel nanomaterials with the aim of developing a new and generic biosensing technology with the potential to be widely applied in many areas including medical diagnostics, environmental control, industry and biosecurity. The outcomes from this project will benefit Australia by contributing through the development of novel materials, new technologies and new devices. ....Microchip Impedance Biosensor for Biomedical Diagnostics. This research proposal uses an innovative engineering approach based on novel nanomaterials with the aim of developing a new and generic biosensing technology with the potential to be widely applied in many areas including medical diagnostics, environmental control, industry and biosecurity. The outcomes from this project will benefit Australia by contributing through the development of novel materials, new technologies and new devices. The development of technological innovations based on fabricated nanomaterials, will also enhance capacity in frontier technology such as nanotechnology, and build Australia’s strength in using new biosensing technologies.Read moreRead less
Milk protein profiling powered by multiplexed single molecule assay. This project aims to develop a novel device, comprising advanced single molecule imaging, microfluidics and immunoassay technologies, for quantification of milk protein variants. Milk quality is central to dairying and variants of proteins in milk affect its market value. No current milk protein detection technologies are readily applied in milk production quality control. This project aims to produce a device that can be used ....Milk protein profiling powered by multiplexed single molecule assay. This project aims to develop a novel device, comprising advanced single molecule imaging, microfluidics and immunoassay technologies, for quantification of milk protein variants. Milk quality is central to dairying and variants of proteins in milk affect its market value. No current milk protein detection technologies are readily applied in milk production quality control. This project aims to produce a device that can be used by milk producers and farms to profile protein variants with high sensitivity in a single test in an hour and screen unwanted protein contamination. The platform also has great potential for detecting other complex and low content analytes. It builds on innovations in nanoparticles and recent industry collaboration.Read moreRead less
Strategies for the detection of designer steroids in racehorses. The Australian racing industry drives economic activity and contributes $1 billion to GDP, $151 million Government revenue and 50,000 jobs in NSW. Racing depends on maintaining the highest standards of integrity. This project will make Australia a world leader by developing robust methods to detect designer steroids in thoroughbred racing.
Bioinks for the 3D printing of cells made from off-the-shelf components. This project aims to develop a simple method for creating complex, multiple-cell-type three-dimensional (3D) cell cultures for in-vitro cell based assays. Using 3D printing technology, this project will develop a versatile polymer system, made from entirely commercially available components, that gels upon printing and has functionality to assist cells in adhering, growing and migrating. The 3D printing of multiple cell typ ....Bioinks for the 3D printing of cells made from off-the-shelf components. This project aims to develop a simple method for creating complex, multiple-cell-type three-dimensional (3D) cell cultures for in-vitro cell based assays. Using 3D printing technology, this project will develop a versatile polymer system, made from entirely commercially available components, that gels upon printing and has functionality to assist cells in adhering, growing and migrating. The 3D printing of multiple cell types will provide biological scientists with more realistic in-vitro cell assays to those found in-vivo. Applications of the research are in cell biology, studying diseases and developing new drugs.Read moreRead less
Automatic cartilage segmentation in magnetic resonance imaging. Osteoarthritis (OA) is the most common form of arthritis, affecting nearly 1.4 million Australians. This research aims at engineering new tools for use in Magnetic Resonance Imaging systems to enable automated analyses of the cartilage and bones in joint images. The goals of the work are to assist with improved diagnosis and treatment planning for both chronic disease, such as OA, and acute injuries, such as cartilage and ligament ....Automatic cartilage segmentation in magnetic resonance imaging. Osteoarthritis (OA) is the most common form of arthritis, affecting nearly 1.4 million Australians. This research aims at engineering new tools for use in Magnetic Resonance Imaging systems to enable automated analyses of the cartilage and bones in joint images. The goals of the work are to assist with improved diagnosis and treatment planning for both chronic disease, such as OA, and acute injuries, such as cartilage and ligament tears in sporting injuries and other traumas.
The software developed will be provided on the project’s partner (Siemens) platform and will therefore be available worldwide and have a consequently large impact on the field.
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Discovery of Novel Respiratory Viruses Causing Influenza-Like Illness in Healthy Australian Adults Aged 18 to 64 Years. This work will inform our understanding of the causes of acute respiratory illnesses in Australia at the present time by looking for both known and previously undiscovered respiratory viruses. Increasing the knowledge base regarding causes of disease will have downstream relevance for health policy planners seeking to assess the burden of disease due to different causes. Early ....Discovery of Novel Respiratory Viruses Causing Influenza-Like Illness in Healthy Australian Adults Aged 18 to 64 Years. This work will inform our understanding of the causes of acute respiratory illnesses in Australia at the present time by looking for both known and previously undiscovered respiratory viruses. Increasing the knowledge base regarding causes of disease will have downstream relevance for health policy planners seeking to assess the burden of disease due to different causes. Early identification and description of new diseases will allow pre-emptive evaluation of new public health threats. This information will help to ensure availability and marketability of vaccines to prevent infection.Read moreRead less
Dynamic magnetic resonance imaging in orthopaedics. The research in this proposal aims at developing new imaging systems that enable joints to be imaged while they are moving. This is an Australian first technology and will change the way in which diagnosis of joint diseases is done. The applications of this new technique include the diagnosis and monitoring of treatment in Osteoarthritis and related chronic joint diseases. Also, acute injuries to knees, hips, shoulders and other joints will be ....Dynamic magnetic resonance imaging in orthopaedics. The research in this proposal aims at developing new imaging systems that enable joints to be imaged while they are moving. This is an Australian first technology and will change the way in which diagnosis of joint diseases is done. The applications of this new technique include the diagnosis and monitoring of treatment in Osteoarthritis and related chronic joint diseases. Also, acute injuries to knees, hips, shoulders and other joints will be able to be better diagnosed and hence improve treatment planning as a result.Read moreRead less
Targeting conjugated markers with new metabolomic methods. Detecting the illicit use of natural steroids like testosterone, or compounds that modulate natural steroid levels, remains the greatest challenge for drug testing in all forms of sport. This project aims to develop new metabolomic methods based on liquid chromatography-high resolution mass spectrometry to detect the changes occurring in the conjugated steroid profile following the administration of steroids or steroid modulators. The in ....Targeting conjugated markers with new metabolomic methods. Detecting the illicit use of natural steroids like testosterone, or compounds that modulate natural steroid levels, remains the greatest challenge for drug testing in all forms of sport. This project aims to develop new metabolomic methods based on liquid chromatography-high resolution mass spectrometry to detect the changes occurring in the conjugated steroid profile following the administration of steroids or steroid modulators. The intended outcome will be a set of sensitive and analytical methods using a range of newly identified conjugated steroid markers and associated reference materials, which promises to enhance integrity and animal welfare in the thoroughbred racing industry.
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Sino-Australian neurogenetics initiative. This project will undertake large population studies to identify genes that are associated with motor neuron disease, schizophrenia and intracranial haemorrhage. The project will determine genetic markers, aid development of diagnostic tools and identify new therapeutic targets for these common heritable neurological diseases.
Rational lateral-bracing design for steel-framed domestic structures. For the 150,000 new Australian houses built annually to remain safe, despite expected increases in structural loading due to climate change, rational design approaches are desperately needed. This project will provide the industry with the necessary tools to develop optimised and innovative solutions to brace houses for extreme events and yet maintain affordability.