Reducing Colorectal Cancer Burden In Young Adults: Precision Prevention And Early Detection
Funder
National Health and Medical Research Council
Funding Amount
$1,449,800.00
Summary
Bowel cancer rate in young adults before age 50 is increasing worldwide including Australia. Since it is impossible to screen everyone, it is critical to identify who is likely to develop the disease, to optimise screening. Using the world's largest resource for young-onset bowel cancer, I will conduct studies to generate high-quality evidence to inform how to best prevent bowel cancer in young adults and translate into the policy and practice, to reduce colorectal cancer burden in young adults.
Develop A Strong Current Warning System And Inform Knowledge Of The Nearshore Current Regime Influencing The Western Rock Lobster Fishery
Funder
Fisheries Research and Development Corporation
Funding Amount
$199,000.00
Summary
By combining this greater coverage with information derived from commercial fishers (e.g. days when gear is drowned or lost to determine key current velocities) a purpose built webapp can be developed, hosted on an existing service, which allows fishers to asses the risks posed by ocean currents to their fishing operation before they set their gear. This would also allow for fishers to predict days when drowned gear may resurface and therefore the fishing operation may continue.
In addi ....By combining this greater coverage with information derived from commercial fishers (e.g. days when gear is drowned or lost to determine key current velocities) a purpose built webapp can be developed, hosted on an existing service, which allows fishers to asses the risks posed by ocean currents to their fishing operation before they set their gear. This would also allow for fishers to predict days when drowned gear may resurface and therefore the fishing operation may continue.
In addition to this helping the fishing operation, greater current modelling coverage over this part of the fishery will allow for the fine-scale assessment of the links between water movement and puerulus settlement. As part of FRDC project “2016-260 WRL IPA: assess causes and implications of anomalous low lobster catch rates in the shallow water areas near the centre of the Western Rock Lobster fishery” 40 additional puerulus collectors will be added to the current DOF monitoring program which will provide extensive coverage of settlement rates between Seven Mile, Dongara and Jurien Bay.
Objectives: 1. Establish additional coastal radar station 2. Establish a predictive warning system for ocean conditions that can be used by the WRL fishery to improve efficiency 3. Assess the relationship between water circulation and puerulus settlement rates Read moreRead less
Circular RNAs As Genome Destabilisers In Human Disease
Funder
National Health and Medical Research Council
Funding Amount
$2,163,220.00
Summary
Mutation of genes are hallmarks of both cancer and neurological disorders. My research group has identified roles for circular RNAs in both these processes. Now, we must close the loop by investigating the mechanism of these processes. This will inform not only why these genes are commonly mutated, but by exploiting the highly stable circular RNAs they may provide early prognostic/diagnostic biomarkers and even represent novel therapeutic targets for cancer and Huntington’s disease.
The Detection Of Ciguatera Toxins In NSW Spanish Mackerel
Funder
Fisheries Research and Development Corporation
Funding Amount
$490,000.00
Summary
Ciguatera Fish Poisoning (CFP) causes the largest number of seafood-related food safety incidents in Australia. In NSW and southern QLD waters, CFP is mostly related to Spanish Mackerel (Scomberomorus commerson). Ciguatoxins (CTXs) produced by marine microalgae (Gambierdiscus spp), are polyether toxins that accumulate in fish and cause CFP when fish are eaten. CTXs are heat stable, odourless, tasteless, and toxic at low concentrations, therefore it is very difficult to distinguish toxic fish. In ....Ciguatera Fish Poisoning (CFP) causes the largest number of seafood-related food safety incidents in Australia. In NSW and southern QLD waters, CFP is mostly related to Spanish Mackerel (Scomberomorus commerson). Ciguatoxins (CTXs) produced by marine microalgae (Gambierdiscus spp), are polyether toxins that accumulate in fish and cause CFP when fish are eaten. CTXs are heat stable, odourless, tasteless, and toxic at low concentrations, therefore it is very difficult to distinguish toxic fish. In NSW, since 2014, 31 people have contracted CFP after consuming Spanish Mackerel caught locally, mostly through recreational fishing.
Validated commercial monitoring methods for CTXs are unavailable internationally, although research tools for CTX measurement have been developed. Regulatory methods for CFP prevention are to avoid certain fish species, fish of certain sizes (ie >10kg), or fish from certain regions. In Australia, effective prevention methods have not been clearly evaluated. This results in Spanish Mackerel that are safe to eat potentially being excluded from sale, resulting in significant losses (ie > ~$200k p.a in NSW). This project addresses this issue, which was identified as high priority in the Australian ciguatera research strategy formulated at a recent workshop (27-28th March, 2019).
In 2014, FRDC (Tactical Response) and the NSW Recreational Fisheries Trust funded an initial study on the incidence of CTXs in NSW Spanish Mackerel. CTX was present in flesh and liver samples (1-7% incidence), and was not clearly correlated with the weight of individual fish. This information showed that CFP risk management may require reassessment. This project will advance knowledge by: evaluating methods of detection of CTXs; determining detailed predictive data on CTX incidence; and evaluating environmental and biological factors associated with CTX in Spanish Mackerel to allow for an evaluation of risk assessment strategies. This information will benefit industry by enhancing consumer safety and industry confidence, and enabling the sale of safe Spanish Mackerel.
Objectives: 1. Determine industry CTX needs and conduct of review of available CTX measurement tools (including cell based assays, ELISA kits, and LCMS) against these needs. Conduct an assessment of the currently available screening tools to determine which, if any, hold promise for industry use. Conduct a viability assessment for how a tool might be used in industry or, if none of the currently available tools are appropriate, make recommendations for future activities to develop a rapid screening tool that meets industry needs. 2. Obtain samples of flesh and liver from ~300 individual Spanish Mackerel of all sizes caught in Industry relevant regions of NSW waters over a period of 2 years, as well as length, weight, sex and site information, with the participation of the Sydney Fish Market and commercial fishing Cooperatives. Obtain samples from any individual Spanish Mackerel associated with illnesses in NSW or QLD. Measure CTX1B and other available CTX analogs using best practice methods identified in Objective 1. 3. Conduct statistical data analyses of all available data on CTX concentrations in Spanish Mackerel in comparison to biological and environmental variables.Develop recommended options for food safety risk management for Spanish Mackerel in NSW that will allow for a viable industry while protecting public health. Read moreRead less
To update assessment reports on Whichfish.com to keep the site current for users. Objectives: 1. 1. Re-organise existing report format in line with the new methodology 2. 2. Update relevant information for the 20 species on Whichfish 3. 3. Reassess risk scores and future outlook sections using draft methodology 4. 4. Provide written feedback about any issues and/or challenges encountered in applying the draft risk assessment which will be incorporated into a guid ....To update assessment reports on Whichfish.com to keep the site current for users. Objectives: 1. 1. Re-organise existing report format in line with the new methodology 2. 2. Update relevant information for the 20 species on Whichfish 3. 3. Reassess risk scores and future outlook sections using draft methodology 4. 4. Provide written feedback about any issues and/or challenges encountered in applying the draft risk assessment which will be incorporated into a guidance document for future assessors and suggestions to improve risk assessment criteria. Read moreRead less
Investigating Aetiology And Risk Factors Of Ocular Lesions And Associated Mortality In Ranched Southern Bluefin Tuna
Funder
Fisheries Research and Development Corporation
Funding Amount
$200,238.00
Summary
This year (2017), some of the ranching operations reported the increased cumulative mortality. In some severe cases, up to 90% of collected mortalities present some degree of unilateral or bilateral ocular damage ranging from corneal cloudiness, with or without ulcers, up to complete perforation. The anecdotal report of eye lesions has progressively increased since the 2015 season without a definitive cause being identified. Previous reports (Rough et al., 1999; Rough, 2000; Hayward et al., 2007 ....This year (2017), some of the ranching operations reported the increased cumulative mortality. In some severe cases, up to 90% of collected mortalities present some degree of unilateral or bilateral ocular damage ranging from corneal cloudiness, with or without ulcers, up to complete perforation. The anecdotal report of eye lesions has progressively increased since the 2015 season without a definitive cause being identified. Previous reports (Rough et al., 1999; Rough, 2000; Hayward et al., 2007; Hayward et al., 2008a; Hayward et al., 2008b; Hayward et al., 2009; Hayward et al., 2010; Hayward et al., 2011, including FRDC projects No 2003/225 and 2008/228, Nowak et al., 2007; Nowak et al., 2012) identified sea lice of the genus Caligus spp. as a differential cause of eye lesions in SBT. The copepod ectoparasite is thought to damage the eyes by feeding on the cornea epithelium of infested SBT. Lesions worsen when fish flash against the cage’s net to dislodge the itchy copepods. Partial or full vision loss is suspected to impair the capacity of the fish to compete for feed and to result, with time, in the death of affected fish. At this stage, it is unclear: 1 - what is the distribution of the observed increased mortality across the industry; 2 - what is the occurrence and severity of eye lesions across the industry; 3 - if the observed increased mortality is entirely attributable to eye lesions; 4 - if eye lesions are solely caused by C. chiastos or if other causes are involved; 5 - if potential tow-, cage-, and fish-level risk factors are associated with the occurrence of eye lesions and its cause(s). Objectives: 1. Estimate the frequency and distribution of increased mortality across the industry. 2. Describe the pathology and severity of eye lesions and estimate the frequency and distribution of these lesions across the industry. 3. Investigate potential tow-, farm-, and fish-level risk factors associated with increased mortality and eye lesion occurrence. 4. Investigate the putative role of sealice in causing this episode of eye lesions. Read moreRead less
Atypical femoral fractures (AFF) are uncommon, but catastrophic, complications of the anti-osteoporosis medications, bisphosphonates. We aim to identify patients either protected from, or at risk of, AFF by identifying changes in their bone geometry, structure and quality, and genes increasing risk of these fractures. In this way, these cheap and effective anti-osteoporosis treatments can be targeted to patients at the lowest risk of AFF and alternative treatments to those at highest risk.
Optimising Engagement In Cardiac Secondary Prevention: A Health Literacy Approach
Funder
National Health and Medical Research Council
Funding Amount
$1,562,250.00
Summary
Many people struggle to maintain a healthy lifestyle after a heart attack. Health literacy is the ability to understand and use health information for better health, but little is known about its role in long-term behaviour change. This research will follow 408 people over 2 years to identify whether health literacy impacts upon lifestyle change after a heart attack. The study will also co-design interventions with consumers and clinicians that aim to improve people’s health literacy.